Author(s): Lin, YJ (Lin, Y-J); Wan, L (Wan, L.); Sheu, JJC (Sheu, J. J-C); Huang, CM (Huang, C-M); Lin, CW (Lin, C-W); Lan, YC (Lan, Y-C); Lai, CH (Lai, C-H); Hung, CH (Hung, C-H);
Tsai, Y (Tsai, Y.); Tsai, CH (Tsai, C-H); Lin, TH (Lin, T-H); Chen, CP (Chen, C-P); Tsai, FJ (Tsai, F-J)
Title: A/C polymorphism in the interleukin-18 coding region among Taiwanese systemic lupus erythematosus patients
Source: LUPUS, 17 (2): 124-127 2008 Language: English
Document Type: Article
Author Keywords: interleukin-18; single nucleotide polymorphism; systemic lupus erythematosus
KeyWords Plus: RHEUMATOID-ARTHRITIS; DISEASE-ACTIVITY; PROINFLAMMATORY CYTOKINES; GENE POLYMORPHISMS; IMMUNE-RESPONSE; IL-18; ASSOCIATION;
PROMOTER; ACTIVATION; ELEVATION
Abstract: Interleukin-18 (IL-18) is associated with chronic inflammation, autoimmune diseases and various cancers and infectious diseases. An IL-18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma and rheumatoid arthritis. We tested a hypothesis that the IL-18 genetic polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Taiwanese SLE patients and a healthy control group.
Our results indicate (1) a significantly higher A allele frequency in SLE patients (P = 0.003; OR
= 1.97; 95% Cl = 1.26-3.08) and (2) a significantly higher A allele frequency in SLE patients with a central nervous system disorder (P = 0.027; OR = 7.18; 95% Cl = 0.95-54.28). Our results suggest that the A/C polymorphism contributes to SLE pathogenesis.
Addresses: [Lin, Y-J; Wan, L.; Sheu, J. J-C; Lin, T-H; Tsai, F-J] China Med Univ Hosp, Dept Med Res, Taichung, Taiwan; [Lin, Y-J] China Med Univ, Grad Inst Acupuncture Sci, Taichung, Taiwan; [Lin, Y-J; Wan, L.; Tsai, C-H; Tsai, F-J] Asia Univ, Dept Biotechnol & Bioinformat, Taichung, Taiwan; [Sheu, J. J-C; Tsai, Y.; Tsai, F-J] China Med Univ, Grad Inst Chinese Med Sci, Taichung, Taiwan; [Huang, C-M] China Med Univ Hosp, Div Rheumatol & Immunol, Taichung, Taiwan; [Lin, C-W] China Med Univ, Dept Med Lab Sci & Biotechnol, Taichung, Taiwan; [Lan, Y-C] China Med Univ, Dept Hlth Risk Management, Taichung, Taiwan; [Lai, C- H; Hung, C-H] China Med Univ, Sch Med, Dept Microbiol, Taichung, Taiwan; [Lin, Y-J; Wan, L.; Sheu, J. J-C] China Med Univ Hosp, Dept Med Genet, Taichung, Taiwan; [Tsai, F-J] China Med Univ Hosp, Dept Pediat, Taichung, Taiwan; [Chen, C-P] MacKay Mem Hosp, Dept Obstet
& Gynecol, Taipei, Taiwan
Reprint Address: Tsai, FJ, China Med Univ Hosp, Dept Med Res, 2 Yuh Der Rd, Taichung, Taiwan.
E-mail Address: [email protected]
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Publisher: SAGE PUBLICATIONS LTD
Publisher Address: 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND ISSN: 0961-2033
DOI: 10.1177/0961203307086031 29-char Source Abbrev.: LUPUS ISO Source Abbrev.: Lupus Source Item Page Count: 4 Subject Category: Rheumatology ISI Document Delivery No.: 276SQ
