Accession number:20094712473404
Title: A platform for identifying microRNA targeting genes
Authors: Weng, Chia-Wei (1); Chiang, ChangChih (1); Ng, Ka-Lok (1);
Huang, Chien-Hung (2)
Author affiliation:(1) Department of Bioinformatics, Asia University, Taichung, 413, Taiwan; (2) Department of Computer Science and Information Engineering, National Formosa University, Yun-Lin, 632, Taiwan
Corresponding author:Ng, K.-L.
Source title: Proceedings of the 2009 9th IEEE International Conference on Bioinformatics and BioEngineering, BIBE 2009
Abbreviated source title:Proc. IEEE Int. Conf. Bioinformatics BioEng., BIBE
Monograph title:Proceedings of the 2009 9th IEEE International Conference on Bioinformatics and BioEngineering, BIBE 2009 Issue date:2009
Publication year:2009 Pages:386-387
Article number:5211240 Language:English
ISBN-13:9780769536569
Document type:Conference article (CA)
Conference name:2009 9th IEEE International Conference on Bioinformatics and BioEngineering, BIBE 2009
Conference date:June 22, 2009 - June 24, 2009 Conference location:Taichung, Taiwan
Conference code:78002
Sponsor:IEEE Computer Society Asia University; Biological and AI Society
Publisher:IEEE Computer Society, 445 Hoes Lane - P.O.Box 1331, Piscataway, NJ 08855-1331, United States
Abstract:We investigate the possibility that microRNA could act as an oncogene or tumor suppressor gene. Experimentally verified microRNA targeted genes information are integrated with microRNA and mRNA expression data to study this hypothesis, in which the Pearson correlation coefficient is used to quantify these relations.
Cancer related microRNA and genes information are retrieved by literature search. Two microRNA targets prediction tools, miRanda and RNAHybrid, are used to obtained the binding minimum free energy and 3'UTR binding position for the target. A web based interface is set up for data display, which can be accessed at http://ppi.bioinfo.asia.edu.tw/mirna-target. © 2009 IEEE.
Number of references:14 Main heading:Bioinformatics
Controlled terms: Binding energy - Free energy - Genes - Tumors Uncontrolled terms: MicroRNA - MicroRNA expression profile - mRNA expression profile - Oncogene - Tumor suppressor gene
Classification code:461.2 Biological Materials and Tissue Engineering - 461.8.2 Bioinformatics - 641.1 Thermodynamics - 801.4 Physical Chemistry - 903 Information Science
DOI:10.1109/BIBE.2009.78 Database:Compendex
Compilation and indexing terms, Copyright 2009 Elsevier Inc.
