題名: HLA-E Gene Polymorphism Associated With Susceptibility to Kawasaki Disease and Formation of Coronary Artery Aneurysms
作者: Lin, YJ (Lin, Y. -J.);Wan, L (Wan, L.);Wu, JY (Wu, J. -Y.);Sheu, JJC (Sheu, J. J. -C.);Lin, CW (Lin, C.
-W.);Lan, YC (Lan, Y. -C.);Lai, CH (Lai, C. -H.);Hung, CH (Hung, C. -H.);Tsai, Y (Tsai, Y.);Tsai, CH (Tsai, C. -H.);Lin, TH (Lin, T. -H.);Lin, JG (Lin, J. -G.);Hsueh, KC (Hsueh, K. -C.);Huang, YM (Huang, Y.
-M.);Chang, JS (Chang, J. -S.);Tsai, FJ (Tsai, F. -J.) 貢獻者: Department of Biotechnology
關鍵詞: TUMOR-NECROSIS-FACTOR;MAJOR HISTOCOMPATIBILITY COMPLEX;ENDOTHELIAL-CELL
ACTIVATION;GAMMA-GLOBULIN;NONSENSE;CHILDREN;RECEPTOR;IMMUNOGLOBULIN;INTERLEUKIN- 1;CD94/NKG2A
日期: 2009-02 上傳時
間:
2010-03-26T02:29:18Z
出版者: Asia University
摘要: Objective. Kawasaki disease (KD) is a pediatric systemic vasculitis of unknown cause for which a genetic influence is supposed. The purpose of this study was to identify possible genetic variants in the major histocompatibility complex (MHC) region that are associated with KD and the
development of coronary artery aneurysms (CAAs) in a Taiwanese population.
Methods. The 168 genetic variants covering the MHC locus were analyzed in an association study of a Taiwanese cohort of 93 KD patients and 680 unrelated healthy children matched for sex and age with the study patients.
Results. Eleven single-nucleotide polymorphisms (SNPs) were associated with the occurrence of KD. The SNP located at the 3'-untranslated region of HLA-E (rs2844724) was highly associated (P <
1 x 10(-7)). In addition, the frequency of the C allele was higher in KD patients without CAAs than in controls (P < 0.001) due to a significantly increased frequency of the CC and CT genotypes.
Plasma levels of soluble HLA-E were significantly higher in KD patients than in controls regardless of the presence of CAAs. Furthermore, there was a trend toward higher plasma levels of soluble HLA-E in KD patients with the CT and TT genotypes of the HLA-E gene polymorphism.
Conclusion. Our results suggest that the HLA-E gene polymorphism may play a role in the pathogenesis of KD.
