Author(s): Su, CC (Su, Chin-Cheng); Yang, JS (Yang, Jai-Sing); Lin, SY (Lin, Shuw-Yuan);
Lu, HF (Lu, Hsu-Feng); Lin, SS (Lin, Song-Shei); Chang, YH (Chang, Yung-Hsien); Huang, WW (Huang, Wen-Wen); Ll, YC (Ll, Yu-Ching); Chang, SJ (Chang, Shu-Jen); Chung, JG (Chung, Jing-Gung)
Title: Curcumin inhibits WEHI-3 leukemia cells in BALB/c mice in vivo Source: IN VIVO, 22 (1): 63-68 JAN-FEB 2008
Language: English Document Type: Article
Author Keywords: curcumin; WEHI-3 leukemia cells; BALB/c mice; cytotoxicity KeyWords Plus: RETINOIC ACID; MYELOMONOCYTIC LEUKEMIA; INDUCED
APOPTOSIS; DIFFERENTIATION; ACTIVATION; MECHANISMS; EXPRESSION; CASPASE- 3; COLO-205
Abstract: Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), a natural polyphenol product of the plant Curcuma longa, exhibited potent inhibitory activities against proliferation, induced cell cycle arrest and exhibited the induction of apoptosis in several tumor cell lines. In our previous studies, we have shown that curcumin induced cell cycle arrest and apoptosis on human leukemia HL-60 and mouse leukemia WEHI-3 cells;
there are no reports regarding whether or not it affects leukemia cells in vivo. In the present study, we investigated the effects of curcumin on WEHI-3 in BALB/c mice and the results indicated that curcumin reduces the percentage of Mac-3 marker, which is the precursor of macrophage. Curcumin induced significant effects on the population of B cells from murine leukemia in vivo. We also investigated the weights of spleen and liver from murine leukemia and the results showed that curcumin reduced the weight of the liver and spleen. From the pathological examinations, the effects of curcumin on the liver and spleen from mice after being injected with WEHI-3 cells were apparent. Both organs were enlarged. In conclusion, curcumin affect WEHI-3 cells in vivo.
Addresses: [Su, Chin-Cheng] Tzu Chi Univ, Buddhist Tzu Chi Gen Hosp, Div Gen Surg, Hualien, Taiwan; [Yang, Jai-Sing] China Med Univ, Dept Pharmacol, Taichung 40402, Taiwan;
[Huang, Wen-Wen; Chung, Jing-Gung] China Med Univ, Dept Biol Sci & Technol, Taichung 40402, Taiwan; [Chang, Yung-Hsien] China Med Univ, Grad Inst Integrat Chinese & Western Med, Taichung 40402, Taiwan; [Lin, Shuw-Yuan] Hung Kuang Univ, Dept Food & Nutr, Taichung, Taiwan; [Lin, Song-Shei] Cent Taiwan Univ Sci & Technol, Dept Radiol Technol, Buzih District, Taiwan; [Ll, Yu-Ching] Cent Taiwan Univ Sci & Technol, Dept Med Technol, Buzih District, Taiwan; [Lu, Hsu-Feng] Cheng Hsin Rehabil Med Ctr, Dept Clin Pathol, Taipei, Taiwan; [Chang, Shu-Jen; Chung, Jing-Gung] Asia Univ, Dept Biotechnol, Wufeng 41354, Taichung County, Taiwan
Reprint Address: Chung, JG, China Med Univ, Dept Microbiol, 91 Hsueh Shih Rd, Taichung
40402, Taiwan.
E-mail Address: [email protected]
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Cited Reference Count: 21 Times Cited: 11
Publisher: INT INST ANTICANCER RESEARCH
Publisher Address: EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22, ATHENS 19014, GREECE
ISSN: 0258-851X
29-char Source Abbrev.: IN VIVO ISO Source Abbrev.: In Vivo Source Item Page Count: 6
Subject Category: Medicine, Research & Experimental ISI Document Delivery No.: 272EC
