xi
Abstract
Polyacrylate is used as the basic frame of transdermal drug delivery system in this study. It was mixed with several aqueous polymers to create a drug-in-adhesive system in sustained release medication. The aqueous polymers evaluated were: Metolose 90SH 15000, Pharmacoat 615, sodium CMC, Carbapol, Metolose 90SH 4000, PVP K30, and PVP K90D.
When polyacrylate was mixed with different concentration of aqueous polymers and were applied on patches, the adhesive forces decrease as concentration ratio of aqueous polymers increased. These formulations of matrix could be useful on introducing the extracts of Chinese medicine to manufacture the transdermal delivery system.
Huperzine A, a reversible and selective cholinesterase inhibitor approved for the treatment of Alzheimer’s disease, is used as a model drug in this study. The physicochemical properties of huperzine A were determined. A stability indicating HPLC procedure for the determination of huperzine A was established and validated. This analytical method was used to study the effect of pH, temperature, and present of hydrogen peroxide on huperzine A.
We explore the release of Chinese medicine by dissolution test. Among these formulations, the aqueous polymers: Metolose 90SH 15000, Metolose 90SH 4000, and sodium CMC could sustain the release of huperzine A for 12 hours.
