Preparation and characterization of magnetic Chitosan/Fe3O4 Nanocomposite particles 黃新義、
E-mail: [email protected]
ABSTRACT
There were two studies in this research. The first one included the preparation of magnetic chitosan/iron (II, III) oxide composite nanoparticles by a spray-drying method. Field emission scanning electron microscopy (FESEM) micrographs indicate that
nanoparticles so prepared have a good sphericity and a rough surface morphology. The average diameters of samples are in range of 200 to 400 nm. Superconducting quantum interference device (SQUID) results indicate that all samples manifest zero coercivity and zero remanence, which infers that each of the samples has a superparamagnetic property. The highest saturation magnetization of samples is about 27.91 emu/g. Dynamic light scattering (DLS) data shows that the zeta potential of samples is higher than 40 mV, indicating that the samples can steadily distribute in water. The second part included the preparation and separation of magnetic chitosan/iron (II, III) oxide micro/nano- particles. In this study, a two-fluid atomizer and spray-drying method was used to prepare magnetic chitosan/iron (II, III) oxide micro/nano- particles. Samples were collected by cyclone collector, multi-stage electromagnet collector, and electrostatic precipitator (ESP), separately. In the multi-stage electromagnet collector, the higher the number of turns (500, 1000, and 1500 turns) in a coil on an electromagnet collector, the higher the strength of electromagnet (200, 250, and 300 G) was found, which was used to collect different size of magnetic micro/nano- particles. Scanning electron microscopy (SEM) micrographs indicate that particles collected by cyclone collector have average diameters in range of 1200 to 5000 nm. Particles collected by multi-stage electromagnet collector have average diameters in range of 300 to 2200 nm. The particles size decreased with increasing the strength of electromagnet. The smallest particles which have diameters in range of 200 to 600 nm were collected by ESP.
Keywords : Chitosan、Spray drying、Iron oxide
Table of Contents
封面內頁 簽名頁 ii 授權書 iii 中文摘要 iv 英文摘要 v 誌謝 vii 目錄 viii 圖目錄 x 表目錄 xii 附錄 xiii 1. 緒言 1 2. 文獻回顧 2 2.1 磁性材料 2 2.1.1物質之磁性歸納 3 2.2幾丁質與幾丁聚醣 5 2.2.1幾丁聚醣的基本特性 6 2.2.2幾丁聚醣的應用 7 2.3奈米科技 14 2.3.1奈米材料維度 14 2.3.2奈米藥物的定義 15 3.以噴霧乾燥法製備磁性幾丁聚醣/四氧化三鐵奈米複合顆粒 16 3.1文獻回 顧 16 3.1.1磁性幾丁聚醣顆粒之製備 16 3.1.2功能性複合粒子 18 3.2研究目的 20 3.3實驗流程 21 3.4材料與儀器設備 22 3.4.1 藥品及耗材 22 3.4.2 儀器設備 22 3.5研究方法 25 3.5.1幾丁聚醣/氧化鐵(II,III)懸浮液之製備 25 3.5.2噴霧乾燥法製備磁性奈 米複合顆粒 25 3.5.3產物分析 26 3.6結果與討論 30 3.6.1磁性幾丁聚醣/氧化鐵(II,III)奈米複合懸浮液之製備 30 3.6.2磁性幾丁 聚醣/氧化鐵(II,III)奈米複合顆粒之組成及結構 30 3.6.3富立葉紅外線光譜儀試驗(FTIR) 32 3.6.4 X光繞射分析試驗(XRD) 38 3.6.5場發射電子顯微鏡觀察(FESEM) 40 3.6.6磁的性質分析 53 3.6.7磁的性質及表面電荷的分析 55 3.7結論 58 4.磁性幾丁聚 醣/四氧化三鐵微奈米粉末之製備及分離 59 4.1文獻回顧 59 4.1.1電磁學由來及發展過程 59 4.1.2磁性分離技術 60 4.2研究目 的 61 4.3材料與儀器設備 62 4.3.1儀器設備 63 4.4研究方法 64 4.4.1磁性流體之製備 64 4.4.2收集設備製造及安裝 65 4.4.3噴 霧乾燥法 65 4.5結果與討論 69 4.5.1磁性幾丁聚醣/四氧化三鐵複合懸浮液 69 4.5.2五段收集器分離微奈米顆粒 69 4.5.3多段 式電磁鐵收集器於磁性微奈米顆粒之分離效果 69 4.5.4掃描電子顯微鏡粒徑及型態觀察 70 4.5.5原子吸收光譜儀試驗 78 4.5.6富立葉紅外線光譜儀試驗 78 4.5.7熱重分析儀試驗 81 4.6結論 84 5.總結 85 ?穧狺暰m 87 附錄 94
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