Author(s): Lin, JP (Lin, Jing-Pin); Yang, JS (Yang, Jai-Sing); Lu, CC (Lu, Chi-Cheng); Chiang, JH (Chiang, Jo-Hua); Wu, CL (Wu, Chang-Lin); Lin, JJ (Lin, Jen-Jyh); Lin, HL (Lin, Hui-Lu);
Yang, MD (Yang, Mei-Due); Liu, KC (Liu, Kuo-Ching); Chiu, TH (Chiu, Tsan-Hung); Chung, JG (Chung, Jing-Gung)
Title: Rutin inhibits the proliferation of murine leukemia WEHI-3 cells in vivo and promotes immune response in vivo
Source: LEUKEMIA RESEARCH, 33 (6): 823-828 JUN 2009 Language: English
Document Type: Article
Author Keywords: Rutin; WEHI-3 leukemia cells; BALB/c mice; Immune response;
Cytotoxicity
KeyWords Plus: ABERRANT CRYPT FOCI; BALB/C MICE; QUERCETIN;
AZOXYMETHANE; VITAMIN-D-3; CANCER; VITRO
Abstract: Flavonoids are polyphenolic compounds found in various foods of plants. Rutin, one of the flavonoids. had been showed induced apoptosis in cancer cells. There is no available information to address rutin affects murine leukemia cells in vivo. In the present study, We are focused on the in vivo effects of rutin on leukemia WEHI-3 cells. The effects of rutin on WEHI- 3 in BALB/c mice in vivo were also examined and the results indicated that rutin decreased the percentage of Mac-3 marker, indicating that the differentiation of the precursor of macrophage and T cells was inhibited. The weights of liver and spleen were decreased from rutin-treated groups compared to the control groups and the results indicated that rutin decreased the weight of these organs. One of the major characteristic of WEHI-3 leukemia is the enlarged spleen in murine after i.p. injection of WEHI-3 cells. After the pathological examination, the function of rutin in was observed in the liver and spleen in the mice previously injected with WEHI-3 cells. Rutin Promoted the activity of macrophage phagocytosis in cells which isolated from peritoneal (i.p.). Taken together, rutin can affect WEHI-3 cells in vivo. (C) 2008 Elsevier Ltd. All rights reserved.
Addresses: [Wu, Chang-Lin; Chung, Jing-Gung] China Med Univ, Dept Biol Sci & Technol, Taichung 404, Taiwan; [Lin, Jing-Pin] China Med Univ, Sch Chinese Med, Taichung 404, Taiwan; [Yang, Jai-Sing] China Med Univ, Dept Pharmacol, Taichung 404, Taiwan; [Lu, Chi- Cheng; Chiang, Jo-Hua] Natl Chung Hsing Univ, Dept Life Sci, Taichung 404, Taiwan; [Lin, Jen-Jyh] China Med Univ Hosp, Dept Med, Div Cardiol, Taichung 404, Taiwan; [Lin, Hui-Lu]
China Med Univ Hosp, Dept Ophthalmol, Taichung 404, Taiwan; [Yang, Mei-Due] China Med Univ Hosp, Dept Surg, Taichung 404, Taiwan; [Liu, Kuo-Ching] China Med Univ, Dept Med Lab Sci & Biotechnol, Taichung 404, Taiwan; [Chiu, Tsan-Hung] China Med Univ Hosp, Dept OBS GYN, Taichung 404, Taiwan; [Chung, Jing-Gung] Asia Univ, Dept Biotechnol, Wufeng 413, Taichung County, Taiwan
Reprint Address: Chung, JG, China Med Univ, Dept Biol Sci & Technol, 91 Hsueh Shih Rd, Taichung 404, Taiwan.
E-mail Address: [email protected]
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Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Publisher Address: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
ISSN: 0145-2126
DOI: 10.1016/j.leukres.2008.09.032 29-char Source Abbrev.: LEUK RES ISO Source Abbrev.: Leuk. Res.
Source Item Page Count: 6
Subject Category: Oncology; Hematology ISI Document Delivery No.: 441LW
