題名:Impairment of the atrial substrates by chronic cigarette smoking in patients with atrial fibrillation.
作者:陳亦仁
Tuan TC; Chang SL; Tai CT; Lin YJ; Hu YF; Lo LW;
Wongcharoen W; Udyavar AR; Chiang SJ; Chen YJ; Tsao HM; Ueng KC; Chen SA.
貢獻者:臨床醫學研究所
上傳時間:2009-08-21T08:58:38Z
摘要:BACKGROUND: Smoking is a major risk factor for
cardiovascular disease. The impact of smoking on the right and left atrial substrates is unknown. METHODS:
This study included 88 patients (age 50 +/- 13 years, M/F = 71/17) who underwent four pulmonary veins
isolation (PVI) for paroxysmal atrial fibrillation (AF).
The mean voltage and total activation time of the
individual atria were obtained by using a NavX mapping system, and were compared between the patients with and without a previous smoking history. The dose effect was evaluated by the smoking intensity-duration, defined as the number of packs per day plus how many years they had been smoking. RESULTS: The right atrial (RA) mean
voltage was lower in the patients with a previous history of smoking than in those without a history of smoking (1.92 +/- 0.49 vs 2.17 +/- 0.56 mV, P < 0.05).
The left atrial (LA) mean voltage was similar between the two groups (1.73 +/- 0.67 vs 1.82 +/- 0.48 mV, P = 0.488). Further, the total activation time of the RA was longer in the patients with a previous history of
smoking than in those without a history of smoking, but not so for the LA. Furthermore, the voltage reduction in the RA was related to the smoking intensity-duration (Pearson's correlation, r = 0.650, P < 0.001).
CONCLUSIONS: In patients with atrial fibrillation, the RA mean voltage and total activation time were
significantly correlated to smoking and had a dose- dependent effect.
