[PDF] Top 20 Lapatinib-induced NF-kappaB activation sensitizes triple-negative breast cancer cells to proteasome inhibitors
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Lapatinib-induced NF-kappaB activation sensitizes triple-negative breast cancer cells to proteasome inhibitors
... that lapatinib, but not specific EGFR inhibitors gefitinib and erlotinib, can induce the phosphorylation and nuclear translocation of p65 and the subsequent expression of NF-B target genes in both ... See full document
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Lapatinib–induced NF-kappaB activation sensitizes triple-negative breast cancer cells to proteasome inhibitors
... Lapatinib–induced NF-kappaB activation sensitizes triple-negative breast cancer cells to proteasome ... See full document
1
OFF-TARGET ACTIVITY OF LAPATINIB SENSITIZES TRIPLE-NEGATIVE BREAST CANCER CELLS TO PROTEASOME INHIBITORS THROUGH ACTIVATION OF NF-κB IN A SFK-DEPENDENT MANNER
... Independent of EGFR/HER2 inhibition, lapatinib-induced NF- κB constitutive activation involves Src family kinase (SFK)-dependent p65 and IκBα phosphorylations in TNBC cells, and thereby[r] ... See full document
1
Lapatinib induces IL-6 expression via MAPK pathway in triple-negative breast cancer cells
... Abstract Lapatinib, the dual Epidermal growth factor receptor (EGFR) and HER2 tyrosine kinase inhibitor (TKI), have been tested in triple negative breast cancer (TNBC) patients in ... See full document
1
Elevation of Histone deacetylase mediates lapatinib-induced cell mobility of triple-negative breast cancer cells through COX-2 overexpression.
... the lapatinib-treated TNBC cells. Treatment with HDAC inhibitors (SAHA and TSA) dramatically reduced lapatinib-mediated cell migration and invasion through down- regulation of COX-2 expression ... See full document
1
Elevation of Histone Deacetylase-3 and -7 Mediates Lapatinib-induced Cell Migration and Invasion of Triple-negative Breast Cancer Cells through COX-2 Overexpression
... by lapatinib remains ...the lapatinib-treated TN cells. Treatment with HDAC inhibitors (SAHA and TSA) or HDAC3 and HDAC7 siRNA dramatically reduced lapatinib-mediated cell migration and ... See full document
2
Lapatinib increases motility of triple-negative breast cancer cells by decreasing MiRNA-7 and inducing Raf-1/MAPK-dependent interleukin-6
... by lapatinib may account for the downregulation of miR-7 and subsequent elevation of the Raf-1/ERK and IL-6 ...addition to its potential role in tumor promotion and progression, overexpression of IL-6 has ... See full document
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The anti-tumor efficiency of pterostilbene is promoted with a combined treatment of Fas signaling or autophagy inhibitors in triple negative breast cancer cells
... 3.4 Activation of ERK1/2 related with PTE transiently regulated EMT ERK1/2 was activated during Fas-induced EMT in gastrointestinal cancer, 8 suggesting that the transient regulation of EMT by PTE ... See full document
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Curcumin Suppresses Doxorubicin-Induced Epithelial-Mesenchymal Transition via the Inhibition of TGF-β and PI3K/AKT Signaling Pathways in Triple-Negative Breast Cancer Cells
... leading to modulation of downstream ...ability to stabilize ...kinasePI3K, to determine if inhibition of AKT activation repressed the doxorubicin-induced ...β-catenin activation ... See full document
1
Lapatinibenhances migration ability of triple-negative breast cancer cells through induction of Raf-1/MAPK-dependent interleukin-6 expression by downergulationof microRNA-7
... the lapatinib-induced migration, suggesting that lapatinib enhances TNBC cell migration through induction of IL-6 ...response to lapatinib treatment to mediate the induction of ... See full document
1
Kinase-inactive EGFR stabilizes COX-2 mRNA to mediate lapatinib-promoted aggressiveness of triple-negative breast cancer cells
... mRNA to mediate lapatinib-promoted aggressiveness of triple-negative breast cancer cells Meng-Chieh Yu, Te-Chun Hsia, Chih-Yen Tu , Ya-Ling Wei , Sheng-Chieh Hsu, ... See full document
3
E1A sensitizes cancer cells to TRAIL-induced apoptosis through enhancement of caspase activation
... shown to induce apoptosis of cancer ...of cancer cells to TRAIL, particularly TRAIL-resistant cancer cells, could improve the effectiveness of TRAIL as an anticancer ... See full document
1
Lapatinib-Mediated Cyclooxygenase-2 Expression via Epidermal Growth Factor Receptor/HuR Interaction Enhances the Aggressiveness of Triple-Negative Breast Cancer Cells
... of Triple-Negative Breast Cancer Cells Te-Chun Hsia, Chih-Yen Tu, Yun-Ju Chen, Ya-Ling Wei, Meng-Chieh Yu, Wen-Shu Chen, Ming-Hsin Yeh, Mien-Chie Hung, and Wei-Chien Huang Center for ... See full document
1
Contribution of personalized Cyclin D1 genotype to triple negative breast cancer risk
... reported to be a potential indicator to triple negative breast cancer [22], were not associated with CCND1 A870G genotype (Table ...in cancer genotyping indeed has done a ... See full document
16
Moscatilin repressed lipopolysaccharide-induced HIF-1alpha accumulation and NF-kappaB activation in murine RAW264.7 cells.
... expected, NF- .B subunit p65 translocated into nucleus after short-time exposure to LPS approximately 5 min and reached peak level approximately 30 min ...10 to 30 2M and had obvious inhibition at 50 ... See full document
6
c-Src mediates thrombin-induced NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells.
... A549 cells, thrombin, SFLLRN-NH2 (a protease-activated receptor 1 (PAR1) agonist peptide), and GYPGQV-NH2 (a PAR4 agonist peptide), but not TFRGAP-NH2 (a PAR3 agonist peptide), induced an increase in ... See full document
2
Proteasome inhibitors overcome lapatinib resistance by downregulation of HER family
... Backgrounds: Lapatinib, a dual EGFR/HER2 tyrosine kinase inhibitor, have shown significant clinical benefits in advanced HER2- positve breast cancer Patients, but the response is not ...failed ... See full document
1
Contribution of DNA Double-strand Break Repair Gene XRCC3 Genotypes to Triple-negative Breast Cancer Risk
... for breast cancer and ...without cancer and those with breast cancer may contribute to a better understanding of the mechanisms of breast cancer by evaluating ... See full document
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Targeting the EGFR/PCNA signaling suppresses tumor growth of triple-negative breast cancer cells with cell-penetrating PCNA peptides
... appeared to be more potent than Y211F CPPP in suppressing the tumor growth of TNBC and reducing tumor volume in ...addition to the subcutaneous implantation, we utilize syngeneic orthotopic implantation ... See full document
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The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer
... tumour cells in the unit of cages, which were randomly ...up to use 5 mice per group to detect a twofold diference with power of 80% and at the significance level of ...Tumour cells in 30 µl ... See full document
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