由五味子萃取層的初步活性試驗中得知，五味子的正己烷層與氯仿層具有良好的抑制 α-glucosidase活性，配合文獻整理結果，推測其活性源自於木脂素類成分，故本研究集中在 於五味子低極性成分中木脂素類化合物的成分分離與活性測試研究。
將五味子之正己烷層與氯仿層藉由矽膠管柱層析、薄層層析、高效能液相層析儀等方
法進行細部分離後，共得到 35 個化合物，並將所得到之化合物經過1H-NMR、IR、UV 分
析結構與文獻比對，確認其中 29 個化合物分別為 macelignan (76)、schisandrin A (78)、
gomisin K3 (80)、gomisin J (81)、schisandrin B (83)、gomisin N (84)、gomisin M2 (85)、
gomisin L2 (86)、(-)-gomisin L1 (87)、(S)-angeloylgomisin M1 (90)、(R)-angeloylgomisin M1 (90)、
schisandrin C (91)、schisandrin (93)、angeloylgomisin H (94)、tigloylgomisin H (95)、
gomisin A (100)、schisandrinen A (101)、gomisin R (113)、gomisin F(126)、gomisin G (128)、
gomisin P(130)、tiglogomisin P (132)、gomisin B (135)、schisanchinin A (142)、gomisin D (153)、
trimethyl citrate (164)、β-sitosterol (165)、
1,1'-(4'',4''',5'',5''',6'',6'''-hexamethoxybiphenyl-2'',2'''-diyl)bis(propan-2-one) (166)、
5-hydroxymethylfuran-2-carboxaldehyde (167)以上二十九個化合物。此外，trimethyl citrate (164)為首次由本植物分離得到；
1,1'-(4'',4''',5'',5''',6'',6'''-hexamethoxybiphenyl-2'',2'''-diyl)bis(propan-2-one) (166) 為首次由天然 來源分離得到的化合物。另外 6 個化合物 SC-A、SC-B、SC-C、SC-D、SC-E 與 SC-F 為新 化合物。
針對化合物的活性試驗結果顯示，在1.0mg/mL的濃度下，有32個化合物對抑制
α-glucosidase活性顯示不錯抑制活性；另外，在IC50試驗中得知，有24個化合物具有良好的
活性。
而在其餘抗氧化能力測試方面，在清除過氧化氫的試驗中，有27個化合物具有活性，
其中有7個化合物有很好的活性。抑制共軛雙烯產生的試驗中發現，有32個化合物具有活性，
當中有13個化合物擁有不錯的活性。在抑制微脂粒氧化的測試中，則有32個化合物具有活 性，其中有15個化合物具有良好的活性。
由本研究中顯示，五味子低極性成分中所含的化合物對於抑制α-glucosidase有很好的活
性，在未來對於糖尿病的治療方面是很有潛力的研究題材。
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