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第五章結論
本論文探討給予 Shh 治療而產生的新生成神經細胞，從行為結果和組織免 疫染色結果，可以看到在給藥後若經過豐富環境刺激，原本在”物品與情境聯合”
試驗有障礙的 ADX 老鼠，在行為上觀察到有恢復的效果，但若只有給 shh 或只有 豐富環境刺激均沒有辦法得到效果，在染色部份亦可發現大部分新神經細胞在行 為測試後一個半小時表現大量 Arc，代表新神經細胞屬於活化狀態，而且大多數 屬於成熟神經細胞,有趣的是不論齒狀迴的總成熟神經細胞之多寡，皆會有固定 比例的新生成成熟神經細胞參與”物品與情境聯合”試驗，可能在某一時間點下，
神經網路會對單一事件做比例分配，預留一些未反應的神經細胞去應付未來可能 發生的事件。
由本論文之實驗結果推論：ADX 老鼠在 Shh 治療產生的新生成神經細胞，在 豐富環境刺激後生存下來，在海馬迴執行學習記憶功能時，這些新神經細胞補足 原本齒狀迴區域已大部分死亡的顆粒細胞，讓 ADX 老鼠恢復學習記憶功能。這些 新神經細胞具有可塑性，不僅取代已死亡的顆粒細胞並且參與在學習記憶中。利 用刺激內生性神經前驅細胞增生及分化並配合豐富環境刺激，未來在神經退化性 疾病的醫療上或許是一個好的治療方式。
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