• 沒有找到結果。

第五章 討論與結論

第四節 結論

本研究以 12 名健康男性,平日有運動習慣之受試者,補充共軛亞麻油酸毎 天 4 克持續 8 週。結果顯示身體組成並未改變 經過四週後,共軛亞麻油酸可能 會破壞其血糖的利用,以 ISI 指數測得之全身胰島素敏感性也顯著變差,建議日 後想以補充 CLA 改變人體身體組成者,應考慮身體葡萄糖的恆定及胰島素敏感 性改變所造成之影響。

參考文獻

Albers, R., van der Wielen, R. P. J., Brink, E. J., Hendriks, H. F. J., Dorovska-Taran, V.

N., & Mohede, I. C. M. (2003). Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men.

European Journal of Clinical Nutrition, 57,595–603.

Aro, A., Männistö, S., Salminen, I., Ovaskainen, M. L., Kataja, V., & Uusitupa, M.

(2000). Inverse association between dietary and serum conjugated linoleic acid and risk of breast cancer in postmenopausal women. Nutrition and Cancer, 38(2), 151-157.

Azain, M. J. (2003). Conjugated linoleic acid and its effects on animal products and health in single-stomached animals. Proceedings of the Nutrition Society, 62, 319-328.

Banting, F. G., & Best, C. H. (1922). The internal secretion of the Pancreas. Journal of Laboratory and Clinical Medicine, 7(5), 251-266.

Bassaganya-Riera, J., Hontecillas-Margarzo, R., Bregendahl, K., Wannemuehler, M.

J., & Zimmerman, D. R. (2001). Effect of dietary conjugated linoleic acid in nursey pigs of dirty and clean environments on growth, empty body composition and immune competence. Journal of Animal Science, 79(3), 714-721.

Basu, S., Risérus, U., Turpeinen, A., & Vessby, B. (2000). Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity. Clinical Science, 99, 511-516.

Bauman, D. E., Baumgard, L. H., Corl, B. A., & Griinari J. M. (1999).Biosynthesis of conjugated linoleic acid in ruminants. Proceedings of the American Society of Animal Science, 1-5.

Belury, M. A., Mahon, A., & Banni, S. (2003). The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. The Journal of Nutrition,

133(1), 257S-260S.

Belury, M. A., Nickelb, K. P., Birdc, C. E., & Wuc, Y. (1996). Dietary conjugated Linoleic acid modulation of phorbol ester skin tumor promotion. Nutrition and Cancer, 26(2), 149-157.Blankson, H., Stakkestad, J. A., Fagertun, H., Thom, E., Wadstein, J., & Gudmundsen, O. (2000). Conjugated linoleic acid reduces body fat mass in overweight and obese humans. The Journal of Nutrition, 130(12), 2943-2948.

Blury, M. A. (2002). Dietary conjugated linoleic acid in health: Physiological effects and mechanisms of action. Annual Review of Nutrition, 22(1), 505-531.

Brown, J. M., & McIntosh, M. K. (2003). Conjugated linoleic acid in humans:

regulation of adiposity and insulin sensitivity. The Journal of Nutrition, 133(10), 3041-3046.

Bulgarella, J. A., Patton, D., & Bull, A. W. (2001). Modulation of prostaglandin H synthase activity by conjugated linoleic acid (CLA) and specific CLA isomers.

Lipids, 36(4), 407-412.

Carlos, T. M., Schwartz, B. R., Kovach, N. L., Yee, E., Rosso, M., Osborn, L., Chi-Rosso, G., Newman, B., Lobb, R., & M. Harlan, J. (1990). Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells. Blood, 76(5), 965-970.

Cartee, G. D., Young, D. A., Sleeper, M. D., Zierath, J., Wallberg-Henriksson, H., &

Holloszy, J. O. (1989). Prolonged increase in insulin-stimulated glucose transport in muscle after exercise. American Journal of Physiology. Endocrinology and Metabolism, 256(4), 494-499.

Cesano, A., Visonneau, S., Scimeca, J. A., Kritchevsky, D., & Santoli, D. (1998).

Opposite effects of linoleic acid and conjugated linoleic acid on human prostatic cancer in SCID mice. Anticancer Research, 18(3A), 1429-1434.

Chajès, V., Lavillonnière, F., Ferrari, P. (2002). Conjugated linoleic acid content in breast adipose tissue is not associated with the relative risk of breast cancer in a population of French patients. Cancer Epidemiol, Biomarkers & Prevention, 11, 672-673.

Choi, J. S., Jung, M. H., Park, H. S., & Song, J. (2004). Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat-fed rats. Nutrition, 20(11), 1008-1017.

Clément, L., Poirier, H., Niot, I., Bocher, V., Guerre-Millo, M., Krief, S., Staels, B., &

Besnard, P. (2002). Dietary trans-10, cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. The Journal of Lipid Research, 43, 1400-1409.

DeFronzo, R. A. (1988). Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes, 37(6), 667-687.

DeLany, J. P., Blohm, F., Truett, A. A., Scimeca, J. A., & West, D. (1999). Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. American Journal of Physiology, 276(4), R1172-R1179.

Du, M., Ahn, D., & Sell, J. L. (1999). Effect of dietary conjugated linoleic acid on the composition of egg yolk lipids. Poultry Science, 78(11), 1639-1645.

Eyjolfson, V., Spriet, L. L., Dyck, D. J. (2004). Conjugated linoleic acid improves insulin sensitivity in young, sedentary humans. Medicine & Science in Sports &

Exercise, 36(5), 814-820.

Evans, M. E., Brown, J. M., & McIntosh, M. K. (2002). Isomer-specific effects of conjugated linoleic acid (CLA) on adiposity and lipid metabolism. The Journal of Nutritional Biochemistry, 13(9), 508-516.

Farese, R. V., Sajan, M. P., & Standaert, M. L. (2005). Insulin-sensitive protein

kinases (a typical protein kinase C and protein kinase B/Akt): actions and defects

in obesity and Type II diabetes. Experimental Biology and Medicine, 230(9), 593-605.

Gaullier, J. M., Berven, G., Blankson, H., & Gudmundsen, O. (2002). Clinical trial results support a preference for using CLA preparations enriched with two isomers rather than four isomers in human studies. Lipids, 37(11), 1019-1025.

Gaullier, J. M., Halse, J., Hoye, K., Kristiansen, K., Fagertun, H., Vik, H., &

Gudmundsen, O. (2004). Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. American Journal of Clinical Nutrition, 79(6), 1118-1125.

Ha, Y. L., Grimm, N. K., & Pariza, M. W. (1987). Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid. Carcinogenesis, 8(12),1881-1887.

Ha, Y. L., Grimm, N. K., & Pariza, M. W. (1989). Newly recognized anticarcinogenic fatty acids: Identification and quantification in natural and processed cheeses.

Journal of Agricultural and Food Chemistry, 37(1), 75-81.

Ha, Y. L., Storkson, J., & Pariza, M. W., (1990). Inhibition of benzo[a]pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid.

Cancer Research, 50, 1097-1101.

Hayek, M. G., Han, S. N., Wu, D., Watkins, B. A., Meydani, M., Dorsey, J. L., Smith, D. E., & Meydani, S. N. (1999). Dietary conjugated linoleic acid influences the immune response of young and old C57BL/bNCrlBR mice. The Journal of Nutrition, 129(1), 32-38.

Henriksen, E. J., Teachey, M. K., Taylor, Z. C., Jacob, S., Ptock, A., Krämer, K., &

Hasselwander, O. (2003). Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker rat. American Journal of

Physiology Endocrinology and Metabolism, 285(1), E98-E105.

Hotamisligil, G. S., & Spiegelman, B. M. (1994). TNFα: a key component of

obesity-diabetes link. Diabetes, 43(11), 1271-1278.

Houseknechta, K. L., Heuvelb, J. P. V, Moya-Camarenac, S. Y., Portocarreroa, C. P., Peckc, L. W., Nickelc, K. P., & Belury, M. A. (1998). Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker Diabetic Fattyfa/faRat.

Biochemical and Biophysical Research Communications, 244(3), 678-682.

Hubbard, N. E., Lim, D., & Erickson, K. L. (2003). Effect of separate conjugated linoleic acid isomers on murine mammary tumorigenesis. Cancer Letters, 190(1), 13-19.

Ip, C., Chin, S. F., Scimecab, J. A., & Pariza, M. W. (1991). Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. Cancer Research, 51, 6118-6124.

Ip, C., Singh, M., Thompson, H. J., & Scimeca, J. A. (1994). Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of mammary gland in the rat. Cancer Research, 54, 1212-1215.

Ip, C., Scimecab, J. A., & Thompsonc, H. (1995). Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention. Nutrition and Cancer, 24(3), 241-247.

Iwata, T., Kamegai, T., Yamauchi-Sato, Y., Ogawa, A., Kasai, M., Aoyama, T. &

Kondo, K. (2007). Safety of dietary conjugated linoleic acid (CLA) in a

12-weeks trial in healthy overweight Japanese male volunteers. Journal of Oleo Science, 56(10), 517-525.

Javadi, M., Beynen, A. C., Hovenier, R., Lankhorst, A., Lemmens, A. G., Terpstra, A.

H. M., & Geelen, M. J. H. (2004). Prolonged feeding of mice with conjugated linoleic acid increases hepatic fatty acid synthesis relative to oxidation. The Journal of Nutritional Biochemistry, 15(11), 680-687.

Jeukendrup, A. E., & Randell, R. (2011). Fat burners: nutrition supplements that

increase fat metabolism. Obesity reviews, 12, 841-851.

Jiang, J., Björck, L., & Fondén, R. (1998). Production of conjugated linoleic acid by dairy starter cultures. Journal of Applied Microbiology, 85(1), 95-102.

Kamphuis, M. M. J. W., Lejeune, M. P. G. M., Saris, W. H. M., Westerterp-Plantenga, M. S. (2003). Effect of conjugated linoleic acid supplementation after weight loss on appetite and food intake in overweight subjects. European Journal of Clinical Nutrition, 57,1268-1274.

Katz, A., Nambi, S. S., Mather, K., Baron, A. D., Follmann, D. A., Sullivan, G., &

Quon, M. J. (2000). Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans. The Journal of Clinical Endocrinology & Metabolism, 85(7), 2402-2410.

Kendall, D. M., & Harmel, A. P. (2002). The metabolic syndrome, type 2 diabetes, and cardiovascular disease: Understanding the role of insulin resistance.

American Journal of Managed Care, 8(20), S635-S653.

Kepler, C. R., Hirons, K. P., McNeill, J. J., & Tove, S. B. (1966). Intermediates and products of the biohydrogenation of linoleic acid by butyrivibrio fibrisolvens.

The Journal of Biological Chemistry, 241(6), 1350-1354.

King, H., & Aubert, R. E. (1998). Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes care, 21(9), 1414-1431.

Kramer, J. K. G., Sehat, N., Dugan, M. E. R., Mossoba, M. M., Yurawecz, M. P., Roach, J. A. G., Eulitz, K., Aalhus, J. L., Schaefer, A. L., & Ku, Y. (1998).

Distributions of conjugated linoleic acid (CLA) isomers in tissue lipid classes of pigs fed a commercial CLA mixture determined by gas chromatography and silver ion-high-performance liquid chromatography. Lipids, 33(6), 549-558 Krook, A., Wallberg-Henriksson, H., & Zierath, J. (2004). Sending the signal:

Molecular mechanisms regulating glucose uptake. Medicine and Science in

Sports and Exercise, 36(7), 1212-1217.

Kuniyasu, H., Yoshida, K., Sasaki, T., Sasahira, T., Fujii, K., & Ohmori, H. (2006).

Conjugated linoleic acid inhibits peritoneal metastasis in human gastrointestinal cancer cells. International Journal of Cancer, 118(3), 571-576.

Larsen, T. M., Toubro, S., Gudmundsen, O., & Astrup, A. (2006). Conjugated linoleic acid supplementation for 1 y does not prevent weight or body fat regain.

American Journal of Clinical Nutrition, 83(3), 606-612.

Larsson, S. C., Bergkvist, L., & Wolk, A. (2005). High-fat dairy food and conjugated linoleic acid intakes in relation to colorectal cancer incidence in the Swedish Mammography Cohort. American Journal of Clinical Nutrition, 82(4), 894-900.

Li, Y., & Watkins, B. A. (1998). Conjugated linoleic acids alter bone fatty acid composition and reduce ex vivo prostaglandin E2 biosynthesis in rats fed n-6 or n-3 fatty acids. Lipids, 33(4), 417-425.

Liew, C., Schut, H. A. J., Chin, S.F., Pariza, M. W. & Dashwood, R. H. (1995).

Protection of conjugated linoleic acids against

2-amino-3-methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms. Carcinogenesis, 16(12), 3037-3043.

Lewis, G. P. (1983). Immunoregulatory activity of metabolites of arachidonic acid and their role in inflammation. British Medical Bulletin, 39(3), 243-248.

Lin, H., Boylston, T. D., Luedecke, L. O., & Shultz, T. D. (1995). Conjugated linoleic acid content of cheddar-type cheeses as affected by processing. Journal of Food Science, 64(5), 874-878.

Malpuech-Brugère, C., Venne, W. V., Mensink, R. P., Arnal, M. A., Morio, B., Brandolini, M., Saebo, A., Lassel, T. S., Chardigny, J. M., Sébédio, J. L., &

Beaufrère, B. (2004). Effects of two conjugated linoleic acid isomers on body fat mass in overweight humans. Obesity Research, 12, 591-598.

Matsuda, M., & DeFronzo, R. A. (1999). Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

Diabetes Care, 22(9), 1462-1470.

Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., &

Turner, R. C. (1985). Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man.

Diabetologia, 28(7), 412-419.

McAuley, K. A., Williams, S. M., Mann, J. I., Walker, R. J., Lewis-Barned, N. J., Temple, L.A., et al. (2001). Diagnosing insulin resistance in the general population. Diabetes Care, 24(3), 460-464.

McFarlane, S. I., Banerji, M., & Sowers, J. R. (2001). Insulin resistance and

cardiovascular disease. The Journal of Clinical Endocrinology and Metabolism, 86(2), 713-718.

McLeod, R. S., LeBlanc, A. M., Langille, M. A., Mitchell, P. L., & Currie, D. L.

(2004). Conjugated linoleic acids, atherosclerosis, and hepatic very-low-density lipoprotein metabolism. American Journal of Clinical Nutrition, 79(6),

1169S-1174S.

Mirand, P. P., Arnal-Bagnard, M. A., Mosoni, L., Faulconnier, Y., Chardigny J. M., &

Chilliard, Y. (2004). Cis-9, Trans-11 and Trans-10, Cis-12 Conjugated Linoleic Acid Isomers Do Not Modify Body Composition in Adult Sedentary or

Exercised Rats. The Journal of Nutrition, 134(9), 2263-2269.

Mizunoya, W., Haramizu, S., Shibakusa, T., Okabe, Y., & Fushiki, T. (2005). Dietary conjugated linoleic acid increases endurance capacity and fat oxidation in mice during exercise. Lipids, 40(3), 265-271.

Moloney, F., Yeow, T. P., Mullen, A., Nolan, J. J., & Roche, H. M. (2004). Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in

patients with type 2 diabetes mellitus. American Journal of Clinical Nutrition, 80(4), 887-895.

Mougios, V., Matsakas, A., Petridou, A., Ring, S., Sagredos, A., Melissopoulou, A., Tsigilis, N., & Nikolaidis, M. (2001). Effect of supplementation with conjugated linoleic acid on human serum lipids and body fat. The Journal of Nutritional Biochemistry, 12(10), 585-594.

Nicolosi, R. J., Rogers, E. J., Kritchevsky, D., Scimeca, J. A., & Huth, P. J. (1997).

Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. Artery, 22(5), 266-277.

Noone, E. J., Roche, H. M., Nugent, A. P., Gibney, M. J. (2002). The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. British Journal of Nutrition, 88(3), 243-251.

Oku, H., Wongtangtintharn, S., Iwasaki, S., & Toda, T. (2003). Conjugated linoleic acid (CLA) inhibits fatty acid synthetase activity in vitro. Bioscience,

Biotechnology, and Biochemistry, 67(7), 1584-1586.

Ostrowska, E., Muralitharan, M., Cross, R. F., Bauman, D. E., & Dunshea, F. R.

(1999). Dietary conjugated linoleic acids increase lean tissue and decrease fat deposition in growing pigs. The Journal of Nutrition, 129(11), 2037-2042.

Pariza, M. W. (1997). Conjugated linoleic acid, a newly recognized nutrient.

Chemistry & Industry, 12(1), 464-466.

Pariza, M. W. (2004). Perspective on the safety and effectiveness of conjugated linoleic acid. American Journal of Clinical Nutrition, 79(6), 1132-1136.

Pariza, M. W., Park, Y., & Cook, M. E. (2000). Mechanisms of action of conjugated linoleic acid: evidence and speculation. Experimental Biology and Medicine, 233(1), 8-13.

Pariza, M. W., Park, Y., & Cook, M. E. (2001). The biologically active isomers of conjugated linoleic acid. Progress in Lipid Research, 40(4), 283-298.

Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., & Pariza, M. W.

(1997). Effect of conjugated linoleic acid on body composition in mice. Lipids, 32(8), 853-858.

Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., & Pariza, M. W.

(1999). Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids, 34(3), 243-248.

Rahman, S. M., Wang, Y., Yotsumoto, H., Cha, J., Han, S., Inoue, S., & Yanagita, T.

(2001). Effects of conjugated linoleic acid on serum leptin concentration,

body-fat accumulation, and beta-oxidation of fatty acid in OLETF rats. Nutrition, 17(5), 385-390.

Rainer, L. & Heiss, C. J. (2004). Conjugated linoleic acid: health implications and effects on body composition. Journal of the American Dietetic Association, 104(6), 963-968.Reaven, G. M. (1988). Role of insulin resistance in human

disease. Diabetes, 37(12), 1595-1607.

Rhodes, C. J., White, M. F. (2002). Molecular insights into insulin action and secretion. European Journal of Clinical Investigation, 32(suppl. 3), 3-13.

Risérus, U., Arner, P., Brismar, K., Vessby, B. (2002). Treatment with dietary

trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care, 25(9), 1516-1521.

Ritzenthaler, K. L., McGuire, M. K., Falen, R., Shultz, T. D., Dasgupta, N., &

McGuire, M. A. (2001). Estimation of conjugated linoleic acid intake by written dietary assessment methodologies underestimates actual intake evaluated by food duplicate methodology. The Journal of Nutrition, 131(5), 1548-1554.

Roche, H. M., Noone, E., Sewter, C., Bennett, S. M., Savage, D., Gibney, M. J.,

O’Rahilly S., & Vidal-Puig, A. J. (2002).Isomer-dependent metabolic effects of conjugated linoleic acid insights from molecular markers sterol regulatory element-binding protein-1c and LXRα. Diabetes, 51(7), 2037-2044.

Ryder, J. W., Portocarrero, C. P., Song, X. M., Cui, L., Yu, M., Combatsiaris, T., Galuska, D., Bauman, D. E., Barbano, D. M., Charron, M. J., Zierath, J. R., &

Houseknecht, K. L. (2001).Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression. Diabetes, 50(5), 1149-1157.

Saltiel, A. R. (2000). The molecular and physiological basis of insulin resistance:

emerging implications for metabolic and cardiovascular diseases. J Clin Invest, 106(2), 163-164.

Satory, D. L, & Smith, S. B. (1999). Conjugated linoleic acid inhibits proliferation but stimulates lipid filling of murine 3T3–L1 preadipocytes. The Journal of Nutrition, 129(1), 92-97.

Sébédio, J. L., Juaneda, P., Dobson, G., Ramilison, I., Martin, J. C., Chardigny, J. M.,

& Christie., W. W. (1997). Metabolites of conjugated isomers of linoleic acid (CLA) in the rat. Biochim. Biophys. Acta, 1345(1),5-10.

Smedman, A., & Vessby, B. (2001). Conjugated linoleic acid supplementation in humans - metabolic effects. Lipids, 36(8), 773-781.

Soonthornpun, S., Setasuban, W., Thamprasit, A., Chayanunnukul, W., Rattarasarn, C.,

& Geater, A. (2003). Novel insulin sensitivity index derived from oral glucose tolerance test. The Journal of Clinical Endocrinology & Metabolism, 88(3), 1019-1023.

Sugano, M., Taujita, A., Yamasaki, M., Noguchi, M., & Yamada, K.(1998).

Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats. Lipids, 33(5), 521-527.

Takahashi, Y., Kushiro, M., Shinohara, K., & Ide, T. (2002). Dietary conjugated linoleic acid reduces body fat mass and affects gene expression of proteins regulating energy metabolism in mice. Comp Biochem Physiol B Biochem Mol Biol;133(3), 395-404.

Terpstra, A. H. (2004). Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature. American Journal of Clinical Nutrition, 79(3), 352-361.

Thom, E., Wadstein, J., & Gudmundsen, O. (2001). Conjugated linoleic acid reduces body fat in healthy exercising humans. The Journal of International Medical Research, 29(5), 392-396.

Thrush, A. B., Chabowski, A., Heigenhauser, G. J., McBride, B. W., Or-Rashid, M., &

Dyck, D. J. (2007). Conjugated linoleic acid increases skeletal muscle ceramide content and decreases insulin sensitivity in overweight, non-diabetic humans.

Applied Physiology, Nutrition, and Metabolism, 32(3), 372-382

Tsuboyama-Kasaoka, N., Takahashi, M., Tanemura, K., Kim, H. J., Tange, T., Okuyama, H., Kasai, M., Ikemoto, S., & Ezaki, O. (2000). Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops

lipodystrophy in mice. Diabetes, 49(9), 1534-1542.

Turband, S., & Hajduch, E. (2011). Protein kinase C isoforms: Mediators of reactive lipid metabolites in the development of insulin resistance. FEBS Letters, 585(2), 269-274.

Turek, J. J., Li, Y., Schoenlein, I. A., Allen, K. G. D., & Watkins., B. A. (1998).

Modulation of macrophage cytokine production by conjugated linoleic acids is influenced by the dietary n-6:n-3 fatty acid ratio. The Journal of Nutritional Biochemistry, 9(5), 258-266.

Verhulst, A., Janssen, G., Parmentier, G., & Eyssen, H. (1987). Isomerization of

polyunsaturated long chain fatty acids by propionibacteria. Syst. Appl. Microbiol., 9, 12-15.

Voorrips, L. E., Brants, H. A. M., Kardinaal, A. F. M., Hiddink, G. J., van den Brandt, P. A., & Goldbohm, R. A. (2002). Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: the Netherlands cohort study on diet and cancer. American Journal of Clinical Nutrition, 76(4), 873-882.

Weber, T. E., Schinkel, A. P., Houseknecht, K. L., & Richert, B. T. (2001). Evaluation of conjugated linoleic acid and dietary antibiotics as growth promotants in weanling pigs. Journal of Animal Science, 79(10), 2542-2549.

West, D. B., Delany, J. P., Camet, P. M., Blohm, F., Truett, A. A., & Scimeca, J.

(1998).Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. American Journal of Physiology, 275(3), R667-R672.

Whigham, L. D., Higbee, A., Bjorling, D. E., Park, Y., Pariza, M. W., & Cook, M. E.

(2002). Decreased antigen-induced eicosanoid release in conjugated linoleic acid-fed guinea pigs. American Journal of Physiology, 282(4), R1104-R1112.

Yamasaki, M., Ikeda, A., Oji, M., Tanaka, Y., Hirao, A., Kasai, M., Iwata, T., Tachibana, H., & Yamada, K. (2003).Modulation of body fat and serum leptin levels by dietary conjugated linoleic acid in Sprague-Dawley rats fed various fat-level diets. Nutrition, 19(1), 30-35.

Zambell, K. L., Horn, W. F., & Keim, N. L. (2001). Conjugated linoleic acid supplementation in humans: effects on fatty acid and glycerol kinetics. Lipids, 36(8), 767-772.

附錄二 受測者同意書

研究題目:8 週補充共軛亞麻油酸對於年輕健康人體胰島素敏感性之影響

研究單位:國立台中教育大學 研究人員:施明谷

共軛亞麻油酸(Conjugated Linoleic Acid, CLA) 是一群含 18 個碳分子,具共 軛雙烯鍵的脂肪酸。CLA 對人類身體健康具有廣大的功效,特別是在身體組成 上,越來越多研究的焦點集中在 CLA 對於胰島素敏感性的功效,本研究將探討 八週口服 CLA 補充是否會影響有運動習慣者全身葡萄糖利用。在研究期間,受 試者須分別在補充 CLA 前、補充後四周及補充後八周分別進行三次口服葡萄糖 耐受度測驗(Oral Glucose Tolerance Test, OGTT)。所有受試者在受試前一天晚上 10 點後開始禁食(可少許飲用不含熱量的水),至受試當天早上 8:30 分接受測 試。口服葡萄糖耐受度試驗檢測流程為受試者在空腹狀況下飲用 75 公克葡萄糖 水搭配 500 毫升純水後開始計時(0 分鐘為基準值),空腹飲用糖水後分別在第 0、30、60、90、120、150、180 分鐘個別抽血,以含 EDTA 的真空採血管收集 3 毫升的靜脈血液供血液生化值分析。

附錄三 口服葡萄糖耐受度測驗步驟

1、所有受試者試驗前一晚隔夜禁食 10 小時(前一晚上十點後勿進食)。

2、於上午 8:30 至實驗室進行本試驗(先不吃早餐)。

3、受試者靜態休息約五分鐘後,由護士先進行第一次空腹抽血。

4、第一次抽血之後,將 75 公克葡萄糖與 500 毫升純水配置成之葡萄糖水,並要 求受試者於五分鐘之內喝完。

5、飲用葡萄糖水時指示受試者攪拌,飲盡時杯底勿殘留葡萄糖粉末。

6、攝取後開始計時,於第 30、60、90、120、150、180 分鐘,由護士使用無菌 拋棄式針頭與 5 ml 針筒,從受試者手部橈骨靜脈抽取 3 ml 靜脈血,置入含

6、攝取後開始計時,於第 30、60、90、120、150、180 分鐘,由護士使用無菌 拋棄式針頭與 5 ml 針筒,從受試者手部橈骨靜脈抽取 3 ml 靜脈血,置入含

相關文件