在中大腦動脈阻塞損傷模型中，阿魏酸(100 mg/kg)於再灌流 24 小時 具有降低腦梗塞面積及神經學缺陷之療效，而其神經保護機轉包括再灌 流早期超氧陰離子及ICAM-1 mRNA 抑制作用，而此抗氧化及抗炎症效 用 可 於 再 灌 流 晚 期 進 一 步 抑 制 NF-κB 、 activated microglia / macrophages、氧化損傷及氧化損傷相關之細胞凋亡。
本論文前面提及目前臨床治療缺血性腦中風較明確有效的是t-PA，但
它在臨床使用有很嚴格的限制及很短的治療窗口(腦缺血發生 3 小時內 方可使用)。除此之外，臨床治療還面臨一項相當大的挑戰，即是腦缺血 -再灌流後之損傷。血栓去除後氧再度進入病灶，伴隨炎症反應、氧化自 由基的產生，加重續發性腦損傷。本研究發現阿魏酸可於腦缺血-再灌流 早期藉由抗氧化(抑制超氧陰離子)及抑制 ICAM-1 達到神經保護效用，
已有研究指出血管內皮 ICAM-1 的表現與腦缺血-再灌流損傷呈正向關 係，而阿魏酸可於再灌流期間抑制ICAM-1 的表現，這顯示了兩個意義：
阿魏酸進到腦病灶血管即可開始進行保護效用，以及具有延長治療窗口 至再灌流期間之療效潛力。更重要的是阿魏酸不僅是多種中藥的有效成 分，更是普遍存在自然界水果、蔬菜及穀類中，和一些新藥開發動輒數 十億美元相比，阿魏酸顯然具備了價廉經濟的莫大優勢。展望今後，除 了更深入探討阿魏酸對抗急、慢性腦缺血效用機轉外，在臨床上也應進 行有計畫中藥(如當歸、川芎水煎劑)治療缺血性腦中風病患之療效評 估。透過不斷且深入之阿魏酸基礎與臨床研究，以期建立更具潛力抗缺 血性腦中風之治療策略。
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