國
立 政 治 大 學
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Na tiona
l Ch engchi University
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第五章、 結論
綜合本實驗結果，新合成雙酚化合物 MH101, MH102、MH103、MH104、
MH106、MH107 和 MH111，透過減少過氧化氫產生的 ROS，進而保護 PC12 神經細胞的作用。另外，新合成雙酚化合物皆可以加強 NGF 誘導 PC12 細胞 神經突生長，但不是透過 Erk1/2 路徑或 STAT3 活化的表現所調控。研究成果 顯示新合成雙酚化合物有潛力作為保護神經細胞與加強神經突生長的藥物，但其 作用機制，需要再進一步實驗確認。而後續研究，將進一步設計新合成雙酚化合 物於動物體之抗氧化與神經滋養作用，評估其神經保護及修補之功能，得以具有 臨床治療的價值。
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