• 沒有找到結果。

綜合實驗結果,得到以下結論:

(1)Carisbamate 在 P21 的 Wistar 大鼠所製備的腦片上,確實在 hippocampus 的 DG 抑制glutamate 受體所引發之興奮性電位並展現濃度依賴性的抑制作用。

(2)Carisbamate 以一個相近的比例抑制 AMPA 或 NMDA 引發的興奮性電流,抑制 配對刺激比率;carisbamate 不會影響胞外給予 AMPA 引發之電流;carisbamate 對 mEPSC 的電流大小不會產生抑制。因此,評估 carisbamate 的抑制作用來自抑制突觸 前減少glutamate 釋放。

(3)Carisbamate 的抑制作用不是透過 L-type 鈣離子通道而來。此突觸前的抑制作用 被認為是carisbamate 抗癲癇作用的之一。

(4)Carisbamate 抑制 glutamate 的釋放以降低 DG 的興奮性並維持 DG 的門閥功能被 認為是該藥的抗癲癇作用之一。

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