AA001218 SOCS3 suppressor of cytokine signaling 3 AA004823 DATF1 death associated transcription factor 1 AA011414 FGA fibrinogen- A alpha polypeptide
AA011445 CASP3 caspase 3- apoptosis-related cysteine protease AA024655 DAPK1 death-associated protein kinase 1
AA029308 MTCP1 mature T-cell proliferation 1
AA047319 PSMA6 proteasome (prosome- macropain) subunit- alpha type- 6 AA070997 PSMB6 proteasome (prosome- macropain) subunit- beta type- 6 AA074438 PRDM4 PR domain containing 4
AA131538 PTHLH parathyroid hormone-like hormone AA131585 JUND jun D proto-oncogene
AA156940 PDCD5 programmed cell death 5
AA159936 SIPA1 signal-induced proliferation-associated gene 1 AA169807 PTCH patched homolog (Drosophila)
AA181300 PSMB8 proteasome (prosome- macropain) subunit- beta type- 8 (large multifunctional protease 7)
AA190401 BID BH3 interacting domain death agonist
AA205392 PLINP-1 papillomavirus L2 interacting nuclear protein 1 AA279114 LRP5 low density lipoprotein receptor-related protein 5 AA281152 CASP9 caspase 9- apoptosis-related cysteine protease AA291322 BIK BCL2-interacting killer (apoptosis-inducing)
AA291484 CYP4B1 cytochrome P450- family 4- subfamily B- polypeptide 1 AA293570 TNFRSF6 tumor necrosis factor receptor superfamily- member 6 AA418907 CYP1A1 cytochrome P450- family 1- subfamily A- polypeptide 1 AA427818 HMGA2 high mobility group AT-hook 2
AA430751 FADD Fas (TNFRSF6)-associated via death domain AA431832 GRN granulin
AA432000 CASP8 caspase 8- apoptosis-related cysteine protease AA433807 TNFAIP3 tumor necrosis factor- alpha-induced protein 3
AA443546 RELA
v-rel reticuloendotheliosis viral oncogene homolog A-nuclear factor of kappa light polypeptide gene enhancer in B-cells 3- p65 (avian)
AA443577 TNFSF13 tumor necrosis factor (ligand) superfamily- member 13 AA447661 PA26 p53 regulated PA26 nuclear protein
AA448641 E2F4 E2F transcription factor 4- p107/p130-binding
AA449119 UBE2M ubiquitin-conjugating enzyme E2M (UBC12 homolog-yeast)
AA453766 CFLAR CASP8 and FADD-like apoptosis regulator AA454588 BCL2L2 BCL2-like 2
AA455281 DAD1 defender against cell death 1 AA457705 IER3 immediate early response 3 AA458861 DAP death-associated protein AA459390 FLJ22169 hypothetical protein FLJ22169 AA460330 LOC96626 pinch-2
AA461110 MGC5560 hypothetical protein MGC5560 AA464049 ANK1 ankyrin 1- erythrocytic
AA464152 QSCN6 quiescin Q6
AA465697 BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like AA477781 CYP51A1 cytochrome P450- family 51- subfamily A- polypeptide 1 AA478268 CTBP1 C-terminal binding protein 1
AA478949 DLG5 discs- large (Drosophila) homolog 5
AA487197 UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog-yeast)
AA487253 MLC-B myosin regulatory light chain AA489629 PBEF pre-B-cell colony-enhancing factor AA608988 TSPY testis specific protein- Y-linked
AA630328 LGALS3 lectin- galactoside-binding- soluble- 3 (galectin 3) AA677185 ANK3 ankyrin 3- node of Ranvier (ankyrin G)
AA702174 BIRC2 baculoviral IAP repeat-containing 2 AA775803 PRDX1 peroxiredoxin 1
AA782337 ANK2 ankyrin 2- neuronal
AA872397 LGALS2 lectin- galactoside-binding- soluble- 2 (galectin 2)
AA884709 CYP11B1 cytochrome P450- family 11- subfamily B- polypeptide 1 AA916906 TRADD TNFRSF1A-associated via death domain
AA928708 CYP8B1 cytochrome P450- family 8- subfamily B- polypeptide 1 AA971278 CYP2S1 cytochrome P450- family 2- subfamily S- polypeptide 1
AA987627 TNFRSF17 tumor necrosis factor receptor superfamily- member 17 AI222585 CYP27B1 cytochrome P450- family 27- subfamily B- polypeptide 1 AI401776 CYP4F8 cytochrome P450- family 4- subfamily F- polypeptide 8 AI870530 MAPK11 mitogen-activated protein kinase 11
AI927284 LGALS1 lectin- galactoside-binding- soluble- 1 (galectin 1) AI927693 CYP4F3 cytochrome P450- family 4- subfamily F- polypeptide 3 AW073366 DEDD death effector domain containing
H05935 CYP27A1 cytochrome P450- family 27- subfamily A- polypeptide 1 H09425 CYP2J2 cytochrome P450- family 2- subfamily J- polypeptide 2 H13622 EPS8 epidermal growth factor receptor pathway substrate 8 H27986 LMO4 LIM domain only 4
H52672 BAK1 BCL2-antagonist/killer 1
H54628 TNFSF10 tumor necrosis factor (ligand) superfamily- member 10 H79306 PDGFRA platelet-derived growth factor receptor- alpha polypeptide H80214 TIMP1 tissue inhibitor of metalloproteinase 1 (erythroid
potentiating activity- collagenase inhibitor) H84982 CHES1 checkpoint suppressor 1
H98620 SYNPR synaptoporin
N20338 LYPLA1 lysophospholipase I
N35070 TNFSF12 tumor necrosis factor (ligand) superfamily- member 12 N53136 CYP2C8 cytochrome P450- family 2- subfamily C- polypeptide 8 N58318 DRIM down-regulated in metastasis
N66957 CYP27A1 cytochrome P450- family 27- subfamily A- polypeptide 1 N71003 PDCD4 programmed cell death 4 (neoplastic transformation
inhibitor)
N74593 FLJ11848 hypothetical protein FLJ11848 R06254 TPD52L2 tumor protein D52-like 2
R14422 SCGN secretagogin- EF-hand calcium binding protein R15301 DEDD death effector domain containing
R25095 TNFSF4 tumor necrosis factor (ligand) superfamily- member 4 (tax-transcriptionally activated glycoprotein 1- 34kDa) R26621 FAIM2 Fas apoptotic inhibitory molecule 2
R37937 CRADD CASP2 and RIPK1 domain containing adaptor with death domain
R51021 CYP26A1 cytochrome P450- family 26- subfamily A- polypeptide 1 R51912 SST somatostatin
R89491 CYP2C9 cytochrome P450- family 2- subfamily C- polypeptide 9
R91077 CYP3A7 cytochrome P450- family 3- subfamily A- polypeptide 7 R92425 CYP3A5 cytochrome P450- family 3- subfamily A- polypeptide 5 T49041 CYP19A1 cytochrome P450- family 19- subfamily A- polypeptide 1 T50790 CYP2A6 cytochrome P450- family 2- subfamily A- polypeptide 6 T68287 CYP2B6 cytochrome P450- family 2- subfamily B- polypeptide 6。
T68758 PSMB1 proteasome (prosome- macropain) subunit- beta type- 1 T73090 SLC22A3 solute carrier family 22 (extraneuronal monoamine
transporter)- member 3
W44684 MPP3 membrane protein- palmitoylated 3 (MAGUK p55 subfamily member 3)
W46439 TFDP1 transcription factor Dp-1
W47090 CDK9 cyclin-dependent kinase 9 (CDC2-related kinase) W61100 BCL2 B-cell CLL/lymphoma 2
W72310 FASTK FAST kinase
附錄表2、論文中所提及之運算公式列表（List of equations used in thesis）。
附錄表3、本研究中所運用之運算公式列表（List of equations used in this study）。
自由度：mn1
m1 m n1ANOVA：the analysis of variance。
LSD：least significant difference test。
MRT：Duncan’s new multiple range test。
HSD：Tukey’s honest significant difference。
TNFAIP3 : C(2.84)
TNFSF12 : A(0.46)/B(0.35)/D(0.32) TNFSF10 : A(0.20)/B(0.12)/C(0.50)/D(0.13) TNFRSF6 : A(0.37)/B(0.30)/D(0.30)
TNFRSF17 : A(0.22)/B(0.18)/D(0.23)
TRADD : C(2.43) CFLAR : A(0.24)/B(0.27)/C(0.36)/D(0.28)
PSMA6 : A(0.09)/B(0.11)/C(0.29)/D(0.12)/E(0.45) PSMB8 : C(3.46)
CRADD: A(0.36)/B(0.23)/D(0.22)
DATF1 :A(0.47)/B(0.28)/C(2.33)/D(0.46) PDCD5 :B(0.48)/C(2.29)
BID : C(3.33)/D(2.21) BCL2 : A(0.43)/B(0.17)/D(0.19)
BNIP3L : A(0.35)/B(0.46) BAK1 :C(2.89)/E(0.46)
FADD :A(0.49)/C(2.48)
DAP : A(2.04) FASTK : A(2.21)/D(2.29)
CASP8 :B(0.44)/C(2.94)
CASP3 : D(0.42) DEDD : A(0.36)/B(0.44)/D(0.23)
FAIM2 : A(0.07)/B(0.07)/C(0.17)/D(0.08) PDCD4 : A(0..43)/B(0.26)/D(0.39)/E(0.44)
CASP9 : C(2.03)
(A)
(B)
A(紫蘇)、 B (霍香)、C(防風)、D(刺五加葉)、E(石蓮花) 綠(Cy5/Cy3<0.5)、紅(Cy5/Cy3>1.5)
附錄圖
1、細胞凋亡途徑中抗癌藥物處理 HepG2 細胞的基因表現樣態（Gene expression
patterns of HepG2 cells treated with antitumer herbal extracts in apoptosis pathway）。(A) NF-κB 基因傳遞途徑中，藉由 TNF-dependent 的基因信號傳遞而使 caspases 活 化所產生的細胞凋亡作用。(B)為 Fas/CD95-mediated 之細胞凋亡途徑 [Dufour and Clavien, 2005]。
(A)
SIPA1 : A(0.33)/B(0.13)/D(0.35)/E(0.29)
SOCS3 : A(0.22)/B(0.43) TNFSF4 : A(0.48)/B(0.39)/D(0.29)
(A-1)
PA26 : A(0.07)/B(0.08)/C(0.25)/D(0.05)
(B)
EPS8 : B(2.05) TFDP1 : E(2.05)
TPD52L2 : D(2.04) TIMP1 : D(0.36)
A(紫蘇)、 B (霍香)、C(防風)、D(刺五加葉)、E(石蓮花) 綠(Cy5/Cy3<0.5)、紅(Cy5/Cy3>1.5)
附錄圖
2、細胞增生途徑中抗癌藥物處理 HepG2 細胞的基因表現樣態（Gene expression
patterns of HepG2 cells treated with antitumer herbal extracts in cell proliferation pathway）。(A) 在 liver-specific 的生物反應中的 PI3K/Akt 基因表現途徑。(A-1)為 mTOR
(mammalian target of rapamycin) 信號調節途徑。(B) 藉由 TNF 途徑的交互影響來誘 導NF-κB 目標基因而調節抗凋亡功能 [Dufour and Clavien, 2005] 。
(A)
CYP2C9 : A(0.45)/B(0.09)/C(0.42)/D(0.34) (B)
CYP1A1 : B(3.15)/C(2.47)/D(2.66)
CYP3A5 : B(0.41)
Cytochrome P450 family
A(紫蘇)、 B (霍香)、C(防風)、D(刺五加葉)、E(石蓮花) 綠(Cy5/Cy3<0.5)、紅(Cy5/Cy3>1.5)
附錄圖
3、肝臟代謝途徑中抗癌藥物處理 HepG2 細胞的 Cytochrome P450 family 基因
表現樣態（Cytochrome P450 family gene expression patterns of HepG2 cells treated with antitumer herbal extracts in liver metablic pathway）。(A)肝臟代謝途徑中，P450 family 基因扮演的角色。(B)列舉 P450 family 基因及其功能。
（http://www.thieme-connect.com/bilder/sld/200101/sld00093.02、http://www.chiro.org/nutrition/FULL/Detoxification_Fig3.jpg）