磁性幾丁聚醣/四氧化三鐵奈米複合顆粒之製備及特性研究 黃新義、
E-mail: [email protected]
摘 要
本研究分為兩部份主題進行論述，第一部份係以噴霧乾燥法製備磁性幾丁聚醣/四氧化三鐵奈米複合顆粒。產物經場發射 電子顯微鏡 (FESEM) 觀察得知奈米複合顆粒呈球狀且表面粗糙，其平均粒徑介於 200~400 nm。超導量子干涉儀 (SQUID) 檢測可看出各樣本具有超順磁的特性、且無矯頑力 (zero coercivity) 及無殘磁 (zero remanence) 的存在，其飽和磁性最高為 27.91 emu/g 。動態光散射分析儀 (DLS) 分析顯示各粒子表面電荷均超過40 mV，所有的樣本可安定分散在水中。論文第二 部分係為磁性幾丁聚醣/四氧化三鐵微奈米粉末之製備及分離。本研究利用二流體噴嘴，以噴霧乾燥方式製備磁性幾丁聚 醣顆/四氧化三鐵微奈米粉末，透過旋風收集器、多段式串聯電磁鐵收集器及靜電集塵器(ESP)來分離收集磁性粉末。藉由 不同電磁鐵的線圈匝數(500圈、1,000圈、1,500 圈)來改變磁場強度(200 G、250 G、300 G)，將不同尺寸之磁性微奈米粉末 予以收集。產物經掃描電子顯微鏡（SEM）進行觀察，在旋風收集器收集之粉末粒徑介於1,200 nm~5,000 nm。電磁鐵收 集器之粉末粒徑介於 300 nm~2,200 nm，而隨著磁場強度增強粉末粒徑有較小之趨勢。ESP收集器收集之粉末其粒徑介於 200 nm~600 nm，為三種收集器中最小之粒徑。
關鍵詞 : 幾丁聚醣、噴霧乾燥、氧化鐵
目錄
封面內頁 簽名頁 ii 授權書 iii 中文摘要 iv 英文摘要 v 誌謝 vii 目錄 viii 圖目錄 x 表目錄 xii 附錄 xiii 1. 緒言 1 2. 文獻回顧 2 2.1 磁性材料 2 2.1.1物質之磁性歸納 3 2.2幾丁質與幾丁聚醣 5 2.2.1幾丁聚醣的基本特性 6 2.2.2幾丁聚醣的應用 7 2.3奈米科技 14 2.3.1奈米材料維度 14 2.3.2奈米藥物的定義 15 3.以噴霧乾燥法製備磁性幾丁聚醣/四氧化三鐵奈米複合顆粒 16 3.1文獻回 顧 16 3.1.1磁性幾丁聚醣顆粒之製備 16 3.1.2功能性複合粒子 18 3.2研究目的 20 3.3實驗流程 21 3.4材料與儀器設備 22 3.4.1 藥品及耗材 22 3.4.2 儀器設備 22 3.5研究方法 25 3.5.1幾丁聚醣/氧化鐵(II,III)懸浮液之製備 25 3.5.2噴霧乾燥法製備磁性奈 米複合顆粒 25 3.5.3產物分析 26 3.6結果與討論 30 3.6.1磁性幾丁聚醣/氧化鐵(II,III)奈米複合懸浮液之製備 30 3.6.2磁性幾丁 聚醣/氧化鐵(II,III)奈米複合顆粒之組成及結構 30 3.6.3富立葉紅外線光譜儀試驗(FTIR) 32 3.6.4 X光繞射分析試驗(XRD) 38 3.6.5場發射電子顯微鏡觀察(FESEM) 40 3.6.6磁的性質分析 53 3.6.7磁的性質及表面電荷的分析 55 3.7結論 58 4.磁性幾丁聚 醣/四氧化三鐵微奈米粉末之製備及分離 59 4.1文獻回顧 59 4.1.1電磁學由來及發展過程 59 4.1.2磁性分離技術 60 4.2研究目 的 61 4.3材料與儀器設備 62 4.3.1儀器設備 63 4.4研究方法 64 4.4.1磁性流體之製備 64 4.4.2收集設備製造及安裝 65 4.4.3噴 霧乾燥法 65 4.5結果與討論 69 4.5.1磁性幾丁聚醣/四氧化三鐵複合懸浮液 69 4.5.2五段收集器分離微奈米顆粒 69 4.5.3多段 式電磁鐵收集器於磁性微奈米顆粒之分離效果 69 4.5.4掃描電子顯微鏡粒徑及型態觀察 70 4.5.5原子吸收光譜儀試驗 78 4.5.6富立葉紅外線光譜儀試驗 78 4.5.7熱重分析儀試驗 81 4.6結論 84 5.總結 85 ?穧狺暰m 87 附錄 94
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