Author(s): Yeh, YH (Yeh, Yen-Hung); Chen, MH (Chen, Ming-Hsiung); Lee, YT (Lee, Ya- Ting); Hsieh, HS (Hsieh, Hung-Sheng); Hwang, DF (Hwang, Deng-Fwu)
Title: Effect of taurine on toxicity of oxidized cholesterol and oxidized fish oil in rats Source: JOURNAL OF FOOD AND DRUG ANALYSIS, 16 (4): 76-85 AUG 2008 Language: English
Document Type: Article
Author Keywords: taurine; oxidized cholesterol; hepatotoxicity; oxidized fish oil; rat
KeyWords Plus: DIETARY OXYSTEROLS; LIPID-PEROXIDATION; LIVER CHOLESTEROL;
SUPPLEMENTATION; GLUTATHIONE; OXIDATION; PLASMA; METABOLISM; DISEASE;
INJURY
Abstract: Taurine (2-aminoethanesulfonic acid) Occurs naturally in food, especially in seafood and meat. The aim of our investigation was to evaluate the effect of dietary taurine on oxidized cholesterol and oxidized fish oil induced toxicity in male Wistar rats. Thirty male wistar rats were fed with diets supplemented with 5% taurine, 2% oxidized cholesterol or 3% oxidized fish oil for 6 weeks. After feeding such diet, taurine could increase the high density lipoprotein- cholesterol (HDL-C) level in plasma, and glutathione (GSH) level in plasma, and decrease the activities of alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST) in plasma, and the levels of low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C), triglyceride, total cholesterol in plasma, and relative ratios of liver weight to body weight and thiobarbituric acid-reactive substances (TBARS.) level in the rat liver caused by oxidized cholesterol and oxidized fish oil. It could reduce the biochemical parameters characteristic in the plasma and rate liver caused by oxidized cholesterol and oxidized fish oil. It was also found that taurine possessed a good recovering effect and a short- term preventing effect from the toxicity of oxidized cholesterol and oxidized fish oil in rats. The results suggest that taurine may play an important role in suppressing effect by oxidized cholesterol and oxidized fish oil induced toxicity in rats.
Addresses: [Yeh, Yen-Hung] Toko Univ, Dept Nutr & Hlth Sci, Chiayi, Taiwan; [Chen, Ming- Hsiung; Hwang, Deng-Fwu] Natl Taiwan Ocean Univ, Dept Food Sci, Chilung, Taiwan; [Lee, Ya-Ting] Chien Kuo Technol Univ, Dept Beauty Sci, Changhua, Peoples R China; [Hsieh, Hung-Sheng] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan
Reprint Address: Yeh, YH, Toko Univ, Dept Nutr & Hlth Sci, Chiayi, Taiwan.
E-mail Address: [email protected]
Cited References: *AM I NUTR, 1977, J NUTR, V107, P1340.
ADDIS PB, 1986, FOOD CHEM TOXICOL, V24, P1021.
ALVAREZ JG, 1983, BIOL REPROD, V29, P548.
APPEL LJ, 1993, ARCH INTERN MED, V153, P1429.
BANKS MA, 1992, ADV EXP MED BIOL, V315, P341.
CAZEVIEILLE C, 1997, BRAIN RES, V755, P91.
CHEN YX, 1993, CHIN MED J, V73, P276.
CHIEN JT, 1998, J AGR FOOD CHEM, V46, P2571.
CHIUEH CC, 1999, FREE RADICAL RES, V31, P641.
DAVIGLUS ML, 1997, NEW ENGL J MED, V336, P1046.
DAWSON R, 1999, MECH AGEING DEV, V107, P73.
DOGRUABBASOGLU S, 2001, HUM EXP TOXICOL, V20, P23.
ERDEM A, 2000, NEPHROL DIAL TRANSPL, V15, P1175.
ERITSLAND J, 1996, AM J CARDIOL, V77, P31.
FRANKEL EN, 1980, PROG LIPID RES, V19, P1.
FUJITA T, 1987, CIRCULATION, V75, P525.
GRIFFITH OW, 1980, ANAL BIOCHEM, V106, P207.
GUYTON C, 1991, TXB MED PHYSL, P344.
HARRIS WS, 1989, J LIPID RES, V30, P785.
HAYES D, 1995, J LEUKOCYTE BIOL, V58, P299.
HUXTABLE RJ, 1992, PHYSIOL REV, V72, P101.
HWANG DF, 1997, NUTR SCI J, V22, P131.
HWANG DF, 1998, FOOD CHEM TOXICOL, V36, P239.
HWANG DF, 2000, FOOD CHEM TOXICOL, V38, P585.
KANG YJ, 1988, TOXICOLOGY, V48, P93.
KANNAN R, 1992, EXP EYE RES, V56, P45.
KAUNITZ H, 1972, LIPIDS, V8, P329.
KIM SK, 2002, FOOD CHEM TOXICOL, V40, P545.
KOHASHI N, 1983, PROG CLIN BIOL RES, V125, P73.
KONOSU S, 1982, CHEM BIOCH MARINE FO, P367.
LIU JF, 1995, J NUTR, V125, P3071.
LYONS MA, 1999, J LIPID RES, V40, P1846.
MILEI J, 1992, AM HEART J, V123, P339.
MILITANTE JD, 2000, CARDIOVASC RES, V46, P393.
MILITANTE JD, 2001, NUTR RES, V21, P93.
MORIN RJ, 1992, BIOL EFFECTS CHOLEST, P191.
MULLER L, 1988, B ENVIRON CONTAM TOX, V40, P301.
MURAKAMI S, 1999, LIFE SCI, V64, P83.
NEGISHI H, 1980, J NUTR SCI VITAMINOL, V26, P309.
NESTEL PJ, 1984, J CLIN INVEST, V74, P82.
OSADA K, 1993, J AGR FOOD CHEM, V41, P1893.
PAGANA KD, 1998, MANUAL DIAGNOSTIC LA, P826.
PANIANGVAIT P, 1995, J FOOD SCI, V52, P57.
PARCELL S, 2002, ALTERN MED REV, V7, P22.
PARK T, 1998, ADV EXP MED BIOL, V442, P319.
PURI SC, 1980, APPL STAT FOOD AGR S, P146.
RANA SK, 1986, BRIT J NUTR, V56, P17.
RONALD L, 1992, CURRENT HEPATOLOGY.
SAAD SY, 2002, CHEMOTHERAPY, V48, P42.
SCHINDLER OS, 1996, Z ERNAHRUNGSWISS, V35, P191.
SCHROEPFER GJ, 2000, PHYSIOL REV, V80, P361.
SCHULLERLEVIS G, 1994, ADV EXP MED BIOL, V359, P31.
SCHUTTE M, 1998, NEUROSCI LETT, V246, P53.
SIMOPOULOS AP, 1991, AM J CLIN NUTR, V54, P438.
TADOLINI B, 1995, BIOCHEM BIOPH RES CO, V213, P820.
TAKAHASHI T, 1985, MUSCLE LIPIDS AQUATI, P24.
TATUM VL, 1990, LIPIDS, V25, P226.
TRACHTMAN H, 1992, AM J PHYSIOL, V262, F117.
VINE DF, 1998, J LIPID RES, V39, P1995.
WANG JH, 1996, SHOCK, V6, P331.
WANG LC, 1998, J CHINESE AGR CHEM S, V35, P612.
WATERS E, 2001, AM J PHYSIOL-GASTR L, V280, G1274.
WRIGHT CE, 1986, ANNU REV BIOCHEM, V55, P427.
YAMORI Y, 1996, ADV EXP MED BIOL, V403, P623.
YAMORI Y, 2001, HYPERTENS RES, V24, P453.
YAN PS, 1990, J AM OIL CHEM SOC, V67, P927.
YANY Y, 2002, WEI SHENG YAN JIU, V31, P63.
YEH YH, 2003, TOXICOLOGY, V179, P21.
YEH YH, 2008, FOOD CHEM, V106, P260, DOI 10.1016/j.foodchem.2007.05.084.
YOKOGOSHI H, 1999, J NUTR, V129, P1705.
ZUNIN P, 1995, J FOOD SCI, V60, P913.
Cited Reference Count: 71 Times Cited: 1
Publisher: BUREAU FOOD DRUG ANALYSIS
Publisher Address: 161-2 KUNYANG STREET, NANGANG, TAIPEI, 00000, TAIWAN ISSN: 1021-9498
29-char Source Abbrev.: J FOOD DRUG ANAL ISO Source Abbrev.: J. Food Drug Anal.
Source Item Page Count: 10
Subject Category: Food Science & Technology; Pharmacology & Pharmacy ISI Document Delivery No.: 344EG
