嘉南藥理科技大學 100 學年度碩士班暨碩士在職專班招生藥理學試題(

(1)

准考證號碼：

^{※注意事項}

請確實核對准考證號碼是否正確

嘉南藥理科技大學 100 學年度碩士班暨碩士在職專班招生藥理學試題

(藥物科技研究所碩士班一般生甲組)

本試題共 1 張2面

一、選擇題：以下共有 25 題選擇題，每題 2 分，共 50 分。每題只有一個正確答案，請將正確答案填入答案欄內否則不予計分。答錯者該題以零分計，不倒扣分數。

選擇題答案欄

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

1. Metoclopramide能促進胃腸蠕動以及止吐作用，主要作用為： (A)Antagonist at M2 receptors (B)Agonist at 5-HT4 receptors (C)Inhibitor of acetylcholinesterase (D)Antagonist at D2 receptors

2. 長期使用含鋁的制酸劑所引起的最主要嚴重副作用為： (A)Diarrhea (B)Systemic alkalosis (C)Phosphate depletion (D)Dementia

3. 高劑量組織胺所產生的血管擴張作用能被下列何者所阻斷? (A)H1 antagonists (B)H2 antagonists (C)H3 antagonists (D)A combination of both (A) and (B)

4. 第一代H1拮抗劑的鎮靜作用主要由下列何種機轉產生? (A)Blockade of brain H3 receptors (B)Blockade of brain muscarinic cholinergic receptors (C)Blockade of brain H1 receptors (D)Either (B) or (C)

5. 下列藥物與其主要的副作用之配對何者錯誤? (A)Anti-CD3 monoclonal antibodies: flu-like symptoms (B)Cyclosporine:

bone marrow depression (C)Corticosteroids: electrolyte imbalance (D)Azathioprine: predisposition to opportunistic infections

6. Cyclosporine 能防止移植器官排斥是基於下列何種機轉? (A)Selectively enhancing B-lymphocyte production of antibody (B)Inhibiting cytotoxic T-lymphocyte responses (C)Inhibiting innate immune responses (D)Selectively depleting

CD3-bearing T-lymphocytes

7. 治療血吸蟲(Schistosoma species)感染時，下列藥物何者有效? (A)Albendazole (B)Praziquantel (C)Ivermectin (D)Niclosamide

8. 下列藥物中，何者不需要在體內轉化成活性代謝物而能直接發揮活性作用? (A)Amantadine (B)Acyclovir (C)Ganciclovir (D)Zidovudine

9. 下列藥物中，何者不是 HIV 反轉錄酶抑制劑(reverse transcriptase inhibitor)? (A)Zidovudine (B)Didanosine (C)Lamivudine (D)Nevirapine

10. 免疫球蛋白(Immunoglobulins)顯示對減輕某些病毒感染有效，但是對下列何種病毒無效? (A)Rabies (B)Hepatitis A (C)Hepatitis B (D)Condyloma acuminatum

11. 下列藥物可以使用於治療 C 型肝炎? (A)Amantadine (B)Interferon (C)Idoxuridine (D)Foscarnet

12. 下列藥物中，何者的吸收在胃酸過低時會大大地減少，因此勿與制酸劑合用? (A)Flucytosine (B)Fluconazole (C)Nystatin (D)Ketoconazole

13. 下列抗黴菌藥物中，何者治療皮膚與指甲的金錢癬(ringworm)有效? (A)Amphotericin B (B)Griseofulvin (C)Nystatin (D)Bacitracin

14. 下列藥物中，何者可用於治療隱球菌腦膜炎(cryptococcal meningitis)? (A)Neomycin (B)Nystatin (C)Amphotericin B (D)Griseofulvin

15. Ethambutol 會產生下列何種不良反應? (A)Deafness (B)Optic neuritis (C)Vesticular toxicity (D)Renal insufficiency 16. 下列藥物何者被用於治療 Clostridium difficile colitis ? (A)Metronidazole (B)Rifampicin (C)Amphotericin B

(D)Clindamycin

17. 下列抗生素中，何者最不適合用於治療 Legionella pneumonia ? (A)Erythromycin (B)Gentamicin (C)Ciprofloxacin (D)Rifampicin

18. 下列何者是 levofloxacin 的作用機轉? (A)干擾 peptidoglycan 之合成 (B)損害細胞膜引起鉀離子流失 (C)抑制 DNA gyrase 與 topoisomerase IV (D)抑制在核糖體上之 peptidyl transfer

＜背面尚有題目＞

(2)

19. 腸球菌(enterococci)對 vancomycin 產生抗藥性是經由下列何種機轉? (A)Efflux mechanism (B)Changes in cell wall precursors, resulting in low affinity for vancomycin binding (C)Altered binding proteins in bacterial cytoplasmic membranes (D)β-Lactamase enzymes

20. 下列抗癌藥物中，何者是經由阻斷 ribonucleotide reductase 而發揮功能的? (A)Bleomycin (B)Hydroxyurea (C)L-Asparaginase (D)Chlorambucil

21. 抗代謝劑(antimetabolites)一般都作用在細胞週期(Cell cycle)的哪一個Phase ? (A)M phase (mitotic phase ) (B)G1 phase (C)S phase (DNA synthetic phase) (D)G2 phase

22. 下列藥物中，何者是屬於 SERM，目前用於預防或治療 osteoporosis ? (A)Calcitonin (B)Alendronate (C)Estrogen (D)Raloxifene

23. Which one of the following is true with regard to renal calcium and phosphate metabolism? (A)Approximately 10 gm of calcium is filtered per day and 1% of that is reabsorbed (B)Furosemide and ethacrynic acid stimulate Na-linked calcium reabsorption (C)Thiazide diuretics can prevent nephrolithiasis by increasing calcium excretion (D)PTH decreases renal phosphate reabsorption

24. Patients treated with the somatostatin analog octreotide are at risk for: (A)Peptic ulcer disease (B)Gallstone formation (C)Rash (D)Hyperthyroidism

25. Insulin action involves all of the following Except: (A)Stimulation of glycogen synthesis in muscle fibers (B)Stimulation of gluconeogenesis in the hepatocytes (C)Stimulation of protein breakdown in muscle fibers (D)Stimulation of fatty acid synthesis in the hepatocytes

二、問答題：以下共有 5 題問答題，每題 10 分，共 50 分 1. 下列藥物合用時可能會有什麼相互作用? 要注意什麼事項?請說明

cDigoxin + Thiazide Diuretics dPhenytoin + Phenobarbital eCholestyramine + Warfarin fClopidogrel + NSAIDs gTriamterene + Lisinopril

c d e f g

2. 請說明鈣離子通道阻斷劑(calcium channel blockers)之分類，並說明其在心血管疾病之治療用途與可能的副作用?

3. 比較 Heparin 與 Warfarin 的藥理作用、使用途徑、臨床監測、中毒時的解毒方法。

4. 何謂「DOT」療法 (Directly Observed Treatment Short course)?實施時提供什麼治療藥物?

5. 請說明磷酸二酯酶(phosphodiesterase)有幾種亞型? 並舉出相關的抑制劑及其臨床用途?

嘉南藥理科技大學 100 學年度碩士班暨碩士在職專班招生 藥理學試題(