Author(s): Hsueh, KC (Hsueh, Kai-Chung); Lin, YJ (Lin, Ying-Ju); Chang, JS (Chang, Jeng- Sheng); Wan, L (Wan, Lei); Tsai, YH (Tsai, Yu-Hsin); Tsai, CH (Tsai, Chang-Hai); Chen, CP (Chen, Chih-Ping); Tsai, FJ (Tsai, Fuu-Jen)
Title: Association of Interleukin-10 A-592C Polymorphism in Taiwanese Children with Kawasaki Disease
Source: JOURNAL OF KOREAN MEDICAL SCIENCE, 24 (3): 438-442 JUN 2009 Language: English
Document Type: Article
Author Keywords: Mucocutaneous Lymph Node Syndrome; Polymorphism; Interleukin-10 KeyWords Plus: TUMOR-NECROSIS-FACTOR; PROMOTER POLYMORPHISM;
CYTOKINE PRODUCTION; INTERFERON-GAMMA; IL-10; GENE; CELL; EXPRESSION;
RECEPTOR; ALPHA
Abstract: Elevated serum levels of interleukin-10 (IL-10) have been reported in patients with Kawasaki disease (KD). IL-10 reduces the inflammatory actions of macrophages and T cells and it may play a significant role in the regulation of inflammatory vascular damage associated with systemic vasculitis. The aim of this study was to examine whether -592 IL-10 promoter polymorphism is a susceptibility or severity marker of KID in Chinese patients in Taiwan. The study included 105 KD patients and 100 normal controls. Genotype and allelic frequencies for the IL-10 gene polymorphism in both groups were compared. There were no significant between-group differences in the genotype distribution of IL-10 A-592C gene polymorphism (P=0.08). However, the frequency of the -592*A allele was significantly increased in the patients with KD compared with controls (71.9% vs. 61.0%, P=0.019). The odds ratio for developing KD in individuals with IL-10 -592*A allele was 1.64 (95% confidence interval, 1.06- 2.52) compared to individuals with the IL-10-592*C allele. No significant difference was observed in the genotype and allelic frequencies for the IL-10 A-592C polymorphism between patients with and without coronary artery lesions. The IL-10-592*A allele may be involved in the development of KD in Taiwanese children.
Addresses: [Hsueh, Kai-Chung; Chang, Jeng-Sheng] China Med Univ Hosp, Dept Pediat, Taichung, Taiwan; [Lin, Ying-Ju] China Med Univ, Grad Inst Acupuncture Sci, Taichung, Taiwan; [Wan, Lei; Tsai, Yu-Hsin; Tsai, Fuu-Jen] China Med Univ, Grad Inst Chinese Med Sci, Taichung, Taiwan; [Lin, Ying-Ju; Wan, Lei; Tsai, Chang-Hai; Tsai, Fuu-Jen] Asia Univ, Dept Biotechnol & Bioinformat, Taichung, Taiwan; [Chen, Chih-Ping] Mackay Mem Hosp, Dept Obstet & Gynecol, Taipei, Taiwan
Reprint Address: Tsai, FJ, China Med Univ Hosp, Dept Med Res, 2 Yuh Der Rd, Taichung, Taiwan.
E-mail Address: [email protected] Funding Acknowledgement:
China Medical University CMU95-142 China Medical University Hospital DMR-91-003
This work was supported by China Medical University (CMU95-142) and China Medical University Hospital (DMR-91-003).
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Publisher: KOREAN ACAD MEDICAL SCIENCES
Publisher Address: 302 75 DONG DU ICHON, DONG YONGSAN KU, SEOUL 140 031, SOUTH KOREA
ISSN: 1011-8934
DOI: 10.3346/jkms.2009.24.3.438
29-char Source Abbrev.: J KOREAN MED SCI ISO Source Abbrev.: J. Korean Med. Sci.
Source Item Page Count: 5
Subject Category: Medicine, General & Internal ISI Document Delivery No.: 462IA
