Author(s): Lin, CC (Lin, Cheng-Chieh); Liu, CS (Liu, Chiu-Shong); Li, CI (Li, Chia-Ing); Lin, WY (Lin, Wen-Yuan); Lai, MM (Lai, Ming-May); Lin, T (Lin, Tsann); Chang, PC (Chang, Pei- Chia); Lee, YD (Lee, Yih-Dar); Chen, CC (Chen, Ching-Chu); Lin, CH (Lin, Chih-Hsueh);
Yang, CW (Yang, Chuan-Wei); Hsiao, CY (Hsiao, Chih-Yi); Chen, W (Chen, Walter); Li, TC (Li, Tsai-Chung)
Title: The relation of metabolic syndrome according to five definitions to cardiovascular risk factors - a population-based study
Source: BMC PUBLIC HEALTH, 9: Art. No. 484 DEC 23 2009 Language: English
Document Type: Article
KeyWords Plus: INTERNATIONAL-DIABETES-FEDERATION; PULSE-WAVE VELOCITY;
CHOLESTEROL EDUCATION-PROGRAM; TREATMENT PANEL-III; C-REACTIVE PROTEIN; HEALTH-ORGANIZATION DEFINITIONS; TAICHUNG COMMUNITY-HEALTH;
CORONARY-HEART-DISEASE; MIDDLE-AGED MEN; INSULIN-RESISTANCE Abstract: Background: Although National Cholesterol Education Program (NCEP),
International Diabetes Federation (IDF), American Heart Association and National Heart, Lung and Blood Institute (AHA/NHLBI), World Health Organization (WHO), and the European Group for the Study of Insulin Resistance (EGIR) definitions of metabolic syndrome (MetS) have been commonly used by studies, little is known about agreement among these five definitions.
We examined the agreement among these five definitions and explored their relationship with risk factors of cardiovascular disease in a Taiwan population.
Methods: A total of 1305 subjects aged 40 years and over in Taiwan were analyzed.
Biomedical markers and anthropometric indices were measured. Agreement among definitions was determined by the kappa statistic. Logistic regression models were fit to estimate the odds of a high cardiovascular risk group for five definitions of MetS.
Results: The agreement among the NCEP, IDF, and AHA/NHLBI definitions was from substantial to very good, and agreement between the WHO and EGIR definitions was also substantial. All MetS definitions were significantly associated prevalence of microalbuminuria, elevated highly sensitive CRP (hs-CRP), and arterial stiffness only in women. In men, MetS by NCEP and AHA/NHLBI was associated with elevated level of hs-CRP and arterial stiffness.
MetS by WHO and EGIR were significantly associated with microalbuminuria. And MetS by WHO was the only MetS definition that significantly associated with prevalence of arterial stiffness (OR: 2.75, 95% CI: 1.22-6.19).
Conclusions: The associations of these five definitions with cardiovascular risk factors were similar in women, and it was evident that the five definitions performed better in women than in men, with higher ORs observed in relation to arterial stiffness, elevated hs-CRP, and higher Framingham risk scores.
Addresses: [Li, Tsai-Chung] China Med Univ, Inst Biostat, Taichung, Taiwan; [Li, Tsai-Chung]
China Med Univ, Ctr Biostat, Taichung, Taiwan; [Lin, Cheng-Chieh; Liu, Chiu-Shong; Lin, Wen-Yuan; Lai, Ming-May; Lin, Tsann; Lin, Chih-Hsueh] China Med Univ Hosp, Dept Family Med, Taichung, Taiwan; [Lin, Cheng-Chieh; Liu, Chiu-Shong; Lin, Wen-Yuan; Lai, Ming-May;
Lin, Tsann; Lin, Chih-Hsueh] China Med Univ, Dept Family Med, Coll Med, Taichung, Taiwan;
[Lin, Cheng-Chieh] Asia Univ, Coll Hlth Sci, Inst Hlth Care Adm, Taichung, Taiwan; [Lin, Cheng-Chieh] China Med Univ, Coll Publ Hlth, Sch & Grad Inst Hlth Care Adm, Taichung, Taiwan; [Chang, Pei-Chia] China Med Univ Hosp, Adm Ctr, Taichung, Taiwan; [Lee, Yih-Dar]
Eli Lilly & Co, Lilly Taiwan, Taipei, Taiwan; [Chen, Ching-Chu] China Med Univ Hosp, Dept Med, Div Endocrinol & Metab, Taichung, Taiwan; [Hsiao, Chih-Yi] China Med Univ, Coll Publ Hlth, Inst Hlth Care Adm, Taichung, Taiwan; [Chen, Walter] China Med Univ, Dept Med, Taichung, Taiwan
Reprint Address: Li, TC, China Med Univ, Inst Biostat, Taichung, Taiwan.
E-mail Address: cclin@mail.cmuh.org.tw; liucs@ms14.hinet.net; a6446@mail.cmuh.org.tw;
wylin@mail.cmu.edu.tw; mmlai@ms26.hinet.net; tsann.lin@msa.hinet.net;
lisa319.tw@yahoo.com.tw; tphillee.tw@yahoo.com.tw; chingchu@ms15.hinet.net;
lys0922lin2005@yahoo.com.tw; T14636@mail.cmuh.org.tw; hsiao.joy@gmail.com;
chenwalt@mail.cmu.edu.tw; tcli@mail.cmu.edu.tw Funding Acknowledgement:
Funding Agency Grant Number
National Science Council of Taiwan NSC93-2314-B-039-025 NSC94-2314-B-039-024
This study was supported by grants from the National Science Council of Taiwan (NSC93- 2314-B-039-025&NSC94-2314-B-039-024).
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Publisher: BIOMED CENTRAL LTD
Publisher Address: 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND ISSN: 1471-2458
Article Number: 484
DOI: 10.1186/1471-2458-9-484
29-char Source Abbrev.: BMC PUBLIC HEALTH ISO Source Abbrev.: BMC Public Health
Source Item Page Count: 9
Subject Category: Public, Environmental & Occupational Health ISI Document Delivery No.: 544LE
