[PDF] Top 20 Joint Effect of Arsenic Methylation Profile and NNK Metabolites on Urothelial Carcinoma

... the joint effects of urinary arsenic species and NNK-related metabolites, including total NNAL and the ratio of NNAL-Gluc/free NNAL, on ...total ... See full document

... exclusion of those of incomplete biological specimen collection or questionnaire information, there was a relatively small sample size in our study; however, there were no differences in other covariates, ... See full document

... activity and decreased mutagen activation [39] , which might therefore result in a protective effect against bladder carcinogenesis [16] ...phism of SULT1A1 is a risk factor for urothelial ... See full document

... system of drinking water in southwest Taiwan to eliminate arsenic exposure from artesian well water (Yang et ...between arsenic exposure and bladder cancer ...inorganic arsenic ... See full document

... system of drinking water in southwest Taiwan to eliminate arsenic exposure from artesian well water (Yang et ...between arsenic exposure and bladder cancer ...inorganic arsenic ... See full document

... activity and decreased mutagen activation [39] , which might therefore result in a protective effect against bladder carcinogenesis [16] ...phism of SULT1A1 is a risk factor for urothelial ... See full document

... that arsenic increased hepatic CYP2A expression and activity, subsequently enhancing urinary HA, keto acid, and N 7 -MeG levels in NNK- treated mice ...detoxification of NNK. By ... See full document

... total arsenic, or high InAs%, or high MMA%, or low DMA% possess poor arsenic methylation ...poor arsenic methylation capability and exposure to cigarette smoking had increased UC ... See full document

... role of oxidative stress on arsenic-related UC risk based on biochemical ...indices of general oxidative stress evaluation, including plasma micronutrients and urinary 8-OHdG, ... See full document

... interview and specimens collection Well-trained personnel carried out standardized personal interviews based on a structured ...demographic and socioeconomic characteristics, general potential risk ... See full document

... interview and specimens collection Well-trained personnel carried out standardized personal interviews based on a structured ...demographic and socioeconomic characteristics, general potential risk ... See full document

... Abstract Arsenic exposure is associated with an increased risk of urothelial carcinoma ...risk and urinary arsenic profile in subjects without evident exposure, 177 UC ... See full document

... that of the controls at ...risk of UC (OR = ...genotype and UC risk, neither in a dominant, nor in a recessive ...error of urinary arsenic species, cumulative exposure of ... See full document

... p21 and CCND1 could regulate the progression of the cell cycle and might increase the susceptibility to inorganic arsenic-related cancer ...goal of our study was to evaluate the roles ... See full document

... sum of iAs 3+ , iAs 5+ , MMA 5+ and DMA 5+ ...proportion of each arsenic species (InAs%, MMA% and DMA%) was calculated by dividing the concentration of each species by the total ... See full document

... Materials and methods Study participants A hospital-based case–controlled study was ...cases and 300 healthy participants as controls from the Medical Center that includes National Taiwan University ... See full document

... influence of common genetic variation in the NER pathway on bladder cancer risk by analyzing 22 single nucleotide polymorphisms (SNP) in seven NER genes (XPC, RAD23B, ERCC1, ERCC2, ERCC4, ERCC5, and ... See full document

... In this study, we defined the urinary HA/total NNAL [HA/total NNAL] ratio as the activation index and NNAL-Gluc/free NNAL [(total NNAL-free NNAL)/free NNAL] ratio as the detoxification[r] ... See full document

... better arsenic methylation capacity, enhancing ...polymorphisms of arsenic-related genes, urinary arsenic profiles and ...value and lower change in MMA% contracted cancer ... See full document

... Materials and methods 2.1. Enrollment of Patients affected with AsUC and non-AsUC In total, 28 urothelial carcinomas were obtained from 14 matched pairs of patients with and ... See full document