Top PDF Pharmacokinetic interactions between carbamazepine and the traditional Chinese medicine Paeoniae Radix

Pharmacokinetic interactions between carbamazepine and the traditional Chinese medicine Paeoniae Radix

Pharmacokinetic interactions between carbamazepine and the traditional Chinese medicine Paeoniae Radix

Abstract The present study was conducted to evaluate the effects of Paeoniae Radix (PR), one of the most famous tonic traditional Chinese medicines, on the pharmacokinetics of carbamazepine (CBZ) in rats and to determine the possible interactions between PR and CBZ. The significant decrease in Tmax indicated that simultaneous oral administration of PR contributed to more rapid absorption of CBZ.

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Effects of Paeonia Radix, a traditional Chinese medicine, on the pharmacokinetics of phenytoin

Effects of Paeonia Radix, a traditional Chinese medicine, on the pharmacokinetics of phenytoin

Abstract BACKGROUND: Phenytoin (PHT), one of the most widely prescribed antiepileptic drugs, has been reported to be associated with numerous drug-drug interactions. However, there are far fewer reports about the pharmacokinetic interactions between PHT and traditional Chinese medicines (TCMs). Paeoniae Radix (PR), one of the well-known TCMs, is used as an adjunct in some epileptic patients. OBJECTIVE:

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芍藥(Paeoniae Radix

芍藥(Paeoniae Radix

when scientific medicine has been provided. Therefore, the interactions between antiepileptic drugs and TCM represent a potential problem for the treatment of epilepsy. Interactions between TCM and antiepileptic drugs may increase or decrease the pharmacological or toxicological effects of either component, however, lack of report about the pharmacokinetic interactions between antiepileptic drugs and TCM.

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Evidence of Potential Harmful Interactions between Western Medications and Traditional Chinese Medicine

Evidence of Potential Harmful Interactions between Western Medications and Traditional Chinese Medicine

evidence-based studies about using HRWM with TCM, a comprehensive review of existing evidence and facts is needed to facilitate health professionals making informed decisions about appropriate use of HRWM with TCM. The aim of this study was to solicit and review existing evidence and reports associated with HRWM-TCM interactions using a structured literature searching approach.

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The Association between Socioeconomic Status and Traditional Chinese Medicine Use among Children in Taiwan

The Association between Socioeconomic Status and Traditional Chinese Medicine Use among Children in Taiwan

associated with higher SES. High-SES adolescent girls were more likely to visit TCM practitioners than low-SES girls. A significant trend was found between SES and TCM utilization, even after controlling for many of the relevant associated factors. To the best of our knowledge, this study is the first to examine the association between

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Pharmacokinetic study of paeoniflorin in mice after oral administration Paeoniae radix extract

Pharmacokinetic study of paeoniflorin in mice after oral administration Paeoniae radix extract

Abstract Quantification of paeoniflorin, the principal bioactive component of Paeoniae radix, in mice plasma following oral administration of Paeoniae radix extract was achieved by using a simple and rapid high-performance liquid chromatographic method. The calibration curve for paeoniflorin was linear (r2 = 0.998) over the concentration range 10-200 ng/ml. The coefficients of variation of intra- and inter-day assays were 15.04, 7.31, 6.14, 6.55, 6.63% and 12.71, 6.07, 3.61, 5.51, 4.52% at concentrations of 10, 60, 100, 160, 200 ng/ml, respectively. The recoveries of paeoniflorin from mice plasma were found to be 74.49, 76.83, 80.38 and 80.56%
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A Review of Potential Harmful Interactions between Anticoagulant/Antiplatelet Agents and Chinese Herbal Medicine

A Review of Potential Harmful Interactions between Anticoagulant/Antiplatelet Agents and Chinese Herbal Medicine

Then, we used a standardized data abstraction checklist on Excel® spreadsheet to extract all relevant data, including common name, scientific name and/or binomial source, plant parts, dose, route of administration, drug name, consequence of interactions, and evidence resources, etc, if they were available. Data for all anticoagulant/antiplatelet agents was extracted regardless of belonging to a drug class or an individual drug. The anticoagulants were composed of heparin and warfarin while antiplatelet agents included aspirin, clopidogrel, dipyridamole and ticlopidine. All relevant data in the literature was extracted and compiled by two of the authors (YLC, YHL), and then validated by the other two authors (HHT, HWL). To cross-validate the retrieved and reviewed information, we conducted the focus group review and discussions. A focus group included five experienced pharmacists practicing in either Western medicine or Chinese medicine on a daily basis in Taiwanese hospitals. Any disagreements about classifications and information conflict were resolved by consensus. Specifically, all of the members in the focus group were trained in both Western and Chinese medicines in a School of Pharmacy and/or their master graduate programs.
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Taiwan folk medicine and traditional Chinese medicine study on the role of interferon-induced

Taiwan folk medicine and traditional Chinese medicine study on the role of interferon-induced

Interferon of anti-virus, anti-swelling and the immune regulation of marks has been very clear. Current source of interferon, including genetic engineering genetic composition of natural and human interferon production, but from natural plants, fungi isolated from the cell components, polysaccharides, etc., some external, non- specific immune revitalizing agent of a disturbance factor inducer (IFN Inducer) also received considerable attention, the province is rich in resources of plants, for medicinal by many, is a very good study material.

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A preliminary study to explore the different characteristics between those elderly who used Traditional Chinese Medicine and not in Taiwan

A preliminary study to explore the different characteristics between those elderly who used Traditional Chinese Medicine and not in Taiwan

While evidence showed that the elderly were more likely to use TCM, the aim of this study was to describe the different characteristics between TCM users and non-TCM users among elderly in Taiwan. “National Health Interview Survey (NHIS) in Taiwan-For individuals aged 65 and above” database was used in this study. TCM users were defined as NHIS interviewees who reported with ever made TCM clinic visits, using Chinese medicine ordinarily, buying TCM products or other herbal medicine, and receiving acupuncture or cupping therapies. In addition to the descriptive analysis, the comparisons of health status and education levels between TCM users and non-TCM users were performed using Chi square tests. The SPSS 12.0 was utilized to perform statistical analysis and p value
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Blocking the DNA repair system by traditional Chinese medicine

Blocking the DNA repair system by traditional Chinese medicine

Conclusion The alkaline residues on Ku86 DNA binding site plays important role in ligand binding. In particular, the Lys338 and Arg403 on Ku70 subunit were the binding hot spots for interacting with glycyrrhizic acid, lith- ospermic acid, and salvianolic acid B. On the other hand, macedonoside C lacked a carbonyl group, which was required to form H-bond with Ku70: Arg403, and results stronger interaction with Ku80 subunit of the Ku heterodimer. Nevertheless, the three carboxyl groups on macedono- side C form stable H-bonds with the alkaline residues on Ku80 subunit, which results stable binding conformation. Based on the CADD design, an efficient Ku86 inhibitor is expected to form strong binding affinity with both Lys338 and Arg403 on Ku70 subunit. Figure 12 demonstrated that the carboxyl groups played a major role in protein-ligand interac- tion. Moreover, the carbonyl group (Figure 12A) and the dihydroxy- phenyl group (Figure 12B) that formed additional H-bond and pi-cation interaction respectively were the key features for stable Ku86-ligand binding. The selected TCM compounds, glycyrrhizic acid, macedonoside C, lithospermic acid, and salvianolic acid B, demonstrated low binding energy and formation of stable Ku86-ligand complexes. We conclude that all four compounds are potential enhancers for radiotherapy.
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Distributions of Usage and the Costs of Conventional Medicine and Traditional Chinese Medicine for Lung Cancer Patients in Taiwan

Distributions of Usage and the Costs of Conventional Medicine and Traditional Chinese Medicine for Lung Cancer Patients in Taiwan

This study has several limitations. First, several herbal medicines were not covered by NHI, and visits at clinics not in contract with the BNHI were not considered in this study. About 10% of the TCM clinics do not have contracts with NHI because of the low insurance amount given by NHI. In addition, cancer patients need rare and expensive Chinese herbal, which is not covered by NHI. The NHIRD data may lead to an underestimation of TCM costs. Second, the data for the clinical stages and types of lung cancer were not available for the study; thus, TCM use and costs stratified by these factors cannot be explored. We also observed that the pattern of TCM use varied according to surgery status. However, we did not observe a significant correlation of surgery and other covariates because of limited sample size of TCM users who have undergone surgery. Thus, we described the utilization pattern of TCM according to surgery status.
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HKUST Symposium on Traditional Chinese Medicine

HKUST Symposium on Traditional Chinese Medicine

Ways to develop a regional industry in traditional Chinese medicine (TCM) will be explored during a symposium at the Hong Kong University of Science and Technology from 27 to 29 May 1997. Among the symposium's invited speakers and guests are prominent researchers and senior government officials from Hong Kong and the Chinese Mainland, including: Prof Zhong Cong from the State

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EVIDENCE OF POTENTIAL HARMFUL INTERACTIONS BETWEEN ASPIRIN/CLOPIDOGREL AND TRADITIONAL CHINESE MEDICINE  ASPIRIN/CLOPIDOGREL與中藥間潛在交互作用之實證探討

EVIDENCE OF POTENTIAL HARMFUL INTERACTIONS BETWEEN ASPIRIN/CLOPIDOGREL AND TRADITIONAL CHINESE MEDICINE ASPIRIN/CLOPIDOGREL與中藥間潛在交互作用之實證探討

Metbods: Information related to interactions between aspirinlclopidogrel and TCM was retrieved from eight interaction-based textbooks , five web resources and several pr[r]

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The History, Mechanism, and Clinical Application of Auricular Therapy in Traditional Chinese Medicine

The History, Mechanism, and Clinical Application of Auricular Therapy in Traditional Chinese Medicine

Zacatus Lusitanus cauterized the ear to treat sciatica after phlebotomy did not produce the desired effect. In 1717, the physician Antonio Maria Valsalva discovered a new point that can alleviate odontalgia after cauterization. In 1810, a professor named Ignazio Colla used a bee needle to stimulate the ear and relieved pain in the lower extremities. After 1850, numerous reports described major cases of ear cauterization conducted for tooth extraction. Journal des Connaissances Medico-Chirurgicales, a French journal, mentioned 13 cases of patients with sciatica treated with ear
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Traditional Chinese Medicine Usage among Schizophrenia Patients

Traditional Chinese Medicine Usage among Schizophrenia Patients

Interestingly, we also find that that the odds of visits to TCM practitioners for patients with ≥2 hospitalizations were about 3.6 times those for patients who, in the previ- ous 2 years, had been hospitalized on only one occasion, or not at all. In other words, patients with more active psychopathology had a greater propensity for visiting TCM practitioners. This is consistent with the findings of Burstein et al. 19 which concluded that CAM usage was associated with greater physical symptoms, as well as the greater intensity of the symptoms, for women who had been recently diag- nosed with early stage breast cancer. It is quite feasible that patients with more active psychopathology have higher lev- els of emotional disturbance, and are thus, in turn, more highly motivated to seek additional methods of treatment. 11 This study also finds that the adjusted odds ratios of patients visiting TCM practitioners decreased with the level of urbanization. To the best of our knowledge, no prior study has ever explored the relationship between CAM usage and the level of urbanization of the community in which the patients reside, although one study in Taiwan, undertaken by Wu et al. 20 did find that almost half of rural families and two-thirds of urban families had, at some time, used CAM.
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Traditional Chinese Medicine Prescription Liver Disease Research

Traditional Chinese Medicine Prescription Liver Disease Research

In this thesis, carbon tetrachloride-induced liver impairment in mice pathological animal models, identification of the hepatoprotective effect of this prescription, and And then do analysis and quantitative active ingredients, for clinical use of the prescription and quality control of reference.

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Traditional Chinese Medicine Prescription Liver Disease Research

Traditional Chinese Medicine Prescription Liver Disease Research

. Chinese medicine in the treatment of acute hepatitis, there are many excellent clinical effectiveness of prescription storm, "Long Dan Xie Gan" is the One of them, unfortunately the lack of scientific evidence. In this thesis, Long Dan Xie Gan biological test, the active ingredient and

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Traditional Chinese Medicine as Dual Guardians against Hypertension and Cancer?

Traditional Chinese Medicine as Dual Guardians against Hypertension and Cancer?

2 Abstract This study utilizes the comprehensive traditional Chinese medicine database TCM Database@Taiwan (http://tcm.cmu.edu.tw/) in conjunction with structure-based and ligand-based drug design to identify multi-function Src inhibitors. The three potential TCM candidates identified as having suitable docking conformations and

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The Association between Traditional Chinese Dietary and Herbal Therapies and Uterine Involution in PostpartumWomen

The Association between Traditional Chinese Dietary and Herbal Therapies and Uterine Involution in PostpartumWomen

Background. Traditional Chinese postpartum care is believed to help in the recovery of women after delivery. Objective. This study investigated the association of elements in dietary and herbal therapy with uterine involution. Methods. Indices of uterine involution were measured ultrasonographically in 127 postpartum women between 4-6 weeks after delivery. A self-reported retrospective questionnaire was used to query women about their frequencies of taking herbal medicines and consuming special diets during the first month after delivery. Correlation coefficients were calculated to identify the associations, then the regression models were used to identify the predictors. Result. Among the herbal medicines and diet, consumption of Eucommia ulmoides (E. ulmoides) negatively correlated with the AP diameter of the uterus and the cavity. E. ulmoides was also the only predictor of maximum AP diameter of the uterus, AP diameter of the uterus 5 cm from the fundus, and the maximum AP diameter of the cavity. Moreover, consumption of Sheng-hau-tang was significantly correlated with anteverted uterus and was a predictor of anteverted uterus. Conclusion. E. ulmoides and Sheng-hau-tang positively correlated with the degree of uterine involution after delivery, implying that both therapies might possess the pharmacological efficacy of uterine contraction in postpartum women.
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Evolution of traditional Chinese medicine education in Taiwan

Evolution of traditional Chinese medicine education in Taiwan

Conclusion and take home message: Further data concluded the need for revised overall management policy in term of institution, introduction of paper-less written examination, multi-level item bank administration and integrated dual role of examination as output standardization and competence certification. Latest policy will be beneficial for school mapping, remediation process for re-taker and administrative effectiveness.

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