[PDF] Top 20 Polymorphisms in One-Carbon Metabolism Pathway Genes, Urinary Arsenic Profile and Urothelial Carcinoma.

... Materials and methods Study participants A hospital-based case–controlled study was ...cases and 300 healthy participants as controls from the Medical Center that includes National Taiwan University ... See full document

... genotype and UC risk, neither in a dominant, nor in a recessive ...of urinary arsenic species, cumulative exposure of cigarette smoking and 8-OHdG levels is similar among three ... See full document

... ntroduction: Polymorphisms in p53, p21 and CCND1 could regulate the progression of the cell cycle and might increase the susceptibility to inorganic arsenic-related cancer ...gene ... See full document

... 5+ and DMA 5+ . The relative proportion of each arsenic species (InAs%, MMA% and DMA%) was calculated by dividing the concentration of each species by the total arsenic ...age, urinary ... See full document

... activity and decreased mutagen activation [39] , which might therefore result in a protective effect against bladder carcinogenesis [16] ...for urothelial cancer [40] , and cigarette smoke ... See full document

... activity and decreased mutagen activation [39] , which might therefore result in a protective effect against bladder carcinogenesis [16] ...for urothelial cancer [40] , and cigarette smoke ... See full document

... of urothelial carcinoma (UC) at a 12-year follow-up, and significant associations of cumulative arsenic exposure (CAE) and MMA% (or and DMA%) on UC risk were also found ...that ... See full document

... size in our study; however, there were no differences in other covariates, such as genotyping or urinary total arsenic levels (data not shown) between people included and excluded from ... See full document

... water in southwest Taiwan to eliminate arsenic exposure from artesian well water (Yang et ...between arsenic exposure and bladder cancer ...inorganic arsenic and UC risk focused ... See full document

... water in southwest Taiwan to eliminate arsenic exposure from artesian well water (Yang et ...between arsenic exposure and bladder cancer ...inorganic arsenic and UC risk focused ... See full document

... Abstract Arsenic exposure is associated with an increased risk of urothelial carcinoma ...risk and urinary arsenic profile in subjects without evident exposure, 177 ... See full document

... results. In the current study, selection bias was minimized even through cases and controls recruited from two different hospitals, because these hospitals both belonged to medical centers and ... See full document

... interview and participant specimen ...demographic and socioeconomic characteristics; general potential risk factors for malignancies such as lifestyle, cigarette smoking, alcohol, tea, and coffee ... See full document

... This study showed that the mean urinary concentration of total arsenics was significantly higher, at 37.67+/-2.98 microg/g creatinine, for UC patients than for healthy controls of 21.1[r] ... See full document

... interview and specimens collection Well-trained personnel carried out standardized personal interviews based on a structured ...demographic and socioeconomic characteristics, general potential risk factors ... See full document

... interview and specimens collection Well-trained personnel carried out standardized personal interviews based on a structured ...demographic and socioeconomic characteristics, general potential risk factors ... See full document

... of urinary arsenic species and NNK-related metabolites, including total NNAL and the ratio of NNAL-Gluc/free NNAL, on ...UC. In a recent study, we did not find a significant interaction ... See full document

... Martial and Methods Total 159 and 308 matched cases and controls were respectively recruited at the Department of Urology and Family Medicine, China Medical University Hospital in ... See full document

... of arsenic in humans ingesting arsenic-containing water is an important factor related to several ...The urinary arsenic species can provide useful insight into the arsenic ... See full document

... of urothelial carcinoma (UC) and urinary arsenic speciation have been evaluated in a few case-control studies; however, the association has not been verified in a ... See full document