[PDF] Top 20 Synthesis and Biological Activity of Ethyl 5-(2'-Alkoxycarbonyl substituted phenoxy)furan-2-carboxylate Derivatives
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Synthesis and Biological Activity of Ethyl 5-(2'-Alkoxycarbonyl substituted phenoxy)furan-2-carboxylate Derivatives
... The structure-activity relationships of these compounds were examined and concluded that ethyl 5-(2'-ethoxycarbonyl-3'-methylphenoxy)furan-2-carboxylate (25), ethyl 5-(2'-methoxycarb[r] ... See full document
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Novel Bifunctional Alkylating Agents, 5,10-Dihydropyrrolo[1,2-b]isoquinoline Derivatives, Synthesis and Biological Activity.
... whether derivatives with a linear tricyclic ring sys- tem also possess potent antitumor activity and/or have superior potency than the corresponding bis(hydroxymethyl)azacyclopen- ta[a]indenes, we ... See full document
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2-[氮-多樣取代苄基]取代苯胺基-4-酮基-4,5-二氫呋喃-3-羧酸乙酯類衍生物之合成及其生理活性; Synthesis and Biological Activity of Certain Ethyl 2-[N-various Substituted benzyl]Substituted anilino-4-oxo-4,5-dihydrofuran-3-carboxylate
... 很多的直接證據支持這樣的論點：用藥物治療要根除癌細胞，其成功的關鍵點，在於 誘導癌細胞凋亡。如果此假設是正確的，將可聯想到幾個問題：1 如何在一群有細胞凋 亡功能缺陷的細胞中誘導其細胞凋亡。2.臨床上很多治療不成功的原因是否與此有關。 3. 臨床上常見癌症治療抗藥性的問題是也否與此有關。目前在細胞死亡路徑的關鍵分子 鑑定有很大的進展，讓我們了解細胞凋亡如何發生。目前已了解細胞凋亡之路徑有很多 ... See full document
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3,6,9-置換唑衍生物之合成與生理活性; Synthesis and Biological Activity of 3,6,9-Substituted Carbazole Derivatives
... 血小板懸浮液（platelet suspension）之製備： 從兔耳靜脈抽出血液， 與 100 mM EDTA 以 1：14（v/v）的比例混 合，混合後， 室溫下立即以 90 ×g 離心 10 分鐘， 取出上層富含血小板 之血漿， 再以 500 ×g 離心 10 分鐘， 除去血漿後， 將下層血小板以含 有 EDTA（2 mM）及 bovine serum albumin（BSA, 3.5 mg / ... See full document
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2-[氮-取代芐基-2'-氟基(或甲氧基) ]苯胺基-4-酮基-4, 5-二氫呋喃-3-羧酸乙酯之合成及其生理活性; Synthesis and Biological Activity of Ethyl 2-{N-substituted benzyl-[2'-fluoro(or methoxy)]}anilino-4-oxo-4,5-dihydrofuran-3-carboxylate
... ﹪O 2 + 5﹪CO 2 ）之 Tyrode 溶液中，將左、右心房及右心室分離，心 室肌則修剪成約 4 mm × 6 mm 之長方形條塊。各組織一端以細絲線 固定於電極底部，置入內含 Tyrode 溶液充以混合氣的組織浴器（organ bath）中，溫度維持 37℃，另一端則連接張力轉能器（force transducer , Type BG 25 , Cleveland , Ohio , ... See full document
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3,6-取代-9-吡啶甲基咔唑類衍生物之合成與生理活性; Synthesis and Biological Activity of 3,6-Substituted 9-Pyridylmethylcarbazole Derivatives
... 第一節 Carbazole 類化合物之研究概況 壹、Carbazole 類化合物之合成方法 Carbazole 類化合物早在 1872 年就從煤油及焦油中被分離出來，運 用於染料工業及高分子聚合物等化學工業上，當時即有 carbazole 類化合 物之合成報告 1-2 ，1964 年 Chakraborty 等從芸香料植物 Murraya Koeniggi (九里香)分離出 girinimbine 後，迄今已有數以百計的 ... See full document
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New Analogues of AHMA as Potential Antitumor Agents: Synthesis and Biological activity
... A series of new analogues of 3-(9-acridinylamino)-5-hydroxymethylaniline (AHMA, 1) and AHMA-ethylcarbamate (2) were synthesized by introducing an O-alkylcarboxylic acid esters to the C[r] ... See full document
1
Abeta Aggregation inhibitors. Part I: Synthesis and biological activity of phenylazo benzenesulfonamides
... Institute of Pharmacology, National Yang-Ming University, 155 Li-Nong St., Sec. 2, Taipei 112, Taiwan Received 18 November 2003; accepted 16 December 2003 Abstract—Phenylazo benzenesulfonamides were ... See full document
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Abeta Aggregation inhibitors. Part I: Synthesis and biological activity of phenylazo benzenesulfonamides
... Phenylazo benzenesulfonamides were designed and synthesized as beta-amyloid (Abeta40) fibril assembly inhibitors, and evaluated for inhibition of Abeta40 aggregation and neurotoxicity [r] ... See full document
1
Synthesis and Structure-Activity Relationships of Tetrahydroindazolone Derivatives as Anticancer Agents
... In here, tetrahydroindazolone derivatives were synthesized and evaluated for biological activity against colon cancer cell (H226), Human T cell lymphoblast-like cell line [r] ... See full document
1
Design and synthesis of 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives as novel anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase
... desired biological activity, and almost all rings (ring A to E) and positions on the cyclolignan skeleton have been ...elimination of the stereogenic centers at C-2 and ... See full document
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Synthesis and Biological Evaluation of Polyenylpyrrole Derivatives as Anti-cancer Agents Acting through Caspases-dependent Apoptosis
... effects of 1b and 1e. When the chloro group was substituted with a bromo or hydrogen or when the 3-chloropyrrole moiety was substituted with a furan ring, the activity was ... See full document
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Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activity
... problem and leading cause of death in the United States and other developed countries ...growth and invasion of tissues and ...therapies and strategies have been developed ... See full document
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Synthesis and anti-hepatitis B virus activity of C4 amide-substituted isosteviol derivatives
... acute and chronic infections in humans. Liver damage, including cirrhosis and hepatocellular carcinoma (HCC), occurs in approximately 80% of chronic HBV ...development of a recombinant ... See full document
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Synthesis and Anticancer Activity of 2, 4-Disubstituted Furo[3,2-b]indole Derivatives
... synthesized and evaluated a series of 2, 4-disubstituted furo[3, 2-b]indole derivatives for anticancer activity and established the structure-activity relationships ... See full document
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Synthesis and Biological Evaluation of Novel bis-Aziridinylnaphthoquinone Derivatives
... series of bis-aziridinylnaphthoquinone derivatives has been ...activities and DNA alkylation abilities of these synthetic bis-aziridinylnaphthoquinone derivatives were ...lines ... See full document
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Convergent/Divergent Synthesis and Photophysical Studies of Alternating Benzene-Furan Oligoaryls from Substituted Propargylic Dithioacetals
... the synthesis of a range of oligoaryls that contain alternating benzene–furan ...range of organicsolvents, thus sim- plifying their ...thesis and isolation of the higher ... See full document
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Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors
... SO 2 group of compound 6 had two hydrogen bonds with Tyr355 but the 5-NO 2 group was not hydrogen bonded to ...compound 5 possessed moderate inhibitory potency against COX-2 ... See full document
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Synthesis of polycyclic and 4,5-diacylthiophene-2-carboxylates via intramolecular Friedel–Crafts alkylations and unusual autooxidative fragmentation of the derivatives obtained from the samarium diiodide-promoted coupling reactions of thiophene-2-carboxylate with carbonyl compounds
... Thiophenes and their polycyclic derivatives exhibit remark- able electrochemical, 1a,b optical, 1c physical, 1d and biologi- cal 1e,f properties that render their extensive applications in material ... See full document
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Biological Activity of Oleanane Triterpene Derivatives Obtained by Chemical Derivatization
... medium and Wnt-3a conditioned medium were prepared as described previously ...C-3 and C-28 positions, compounds 1–6 revealed greater cytotoxic and antibacterial potential than their parent ...uptake ... See full document
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