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Appendix Fig. 1 Chemical structure of Sorafenib.
This figure is taken from
http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021923s012lb l.pdf
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Appendix Fig. 2 Molecular mechanisms of Sorafenib. (A) Sorafenib
inhibits tumor cell proliferation and promotes apoptosis. (B) Sorafenib reduces tumor angiogenesis. This figure is taken from Hepatology Research 2012. (Gauthier & Ho, 2012).120
Appendix Fig. 3 Curcuma longa Plant and chemical structure of
curcumin, an active ingredient of rhizome termeric. This figure is
taken from Cell Div, 3, 14, 2008. (Sa & Das, 2008).121
Appendix Fig. 4 Curcumin significanlty inhibited protein expression of Aurora-A. Human bladder cancer cell line T24 (1×10
6 cells/dish) and Human breast cancer cell line MCF-7 (1×106 cells/dish) were exposed to 3 concentrations (10, 20, and 30 M) of curcumin for 48 h. Total protein was subjected to Western blot analysis. Anti-Aurora-A antibody was served as a probe. β-actin was served as a loading control.Results are representative of three independent experiments. This figure is our own unpublished data.
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Appendix Fig. 5 Curcumin enhanced chemosensitivity of human
breast cancer cells to Ixabepilone (FDA approved drug for patients
with breast cancer). MCF-7 cells were exposed to 3 concentrations of
Ixabepilone (25-100 nM) in the presence or absence of curcumin (30 M) for 48 h. Growth inhibition was evaluated by MTT assay. The value of q indicates synergism when greater than 1.15, antagonism when smaller than 0.85, and additivity when located between 0.85 and 1.15. Data are presented as means ± SEM. ＊＊, p < 0.01. Results are representative of three independent experiments. This figure is our own unpublished data.123
Appendix Fig. 6 The apoptosis pathway.
This figure is taken from Frontiers in Bioscience 14, 4015-4034, January 1, 2009(Bellance,
Lestienne, & Rossignol, 2009).124
Appendix Fig. 7 The process of autophagy.
This figure is taken from World J Biol Chem. 2012 January 26; 3(1): 1-6(Abounit, Scarabelli, &McCauley, 2012)
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Appendix Fig. 8 The mammalian cell cycle.
This figure is taken from Drug Discovery Today: Therapeutic Strategies, Volume 1, Issue 4,December 2004 (Fischer, Glover, & Lane, 2004)
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