本研究中第二型糖尿病患白袍高血壓的發生率為 11.8 %,能用來預 測第二型糖尿病患發生白袍效應的因子只有臨床收縮壓值、日夜間血壓 差值與心率變異性總功率。
第二型糖尿病患演進至心血管疾病與神經病變的發生,在病理與生 理上的改變以及治療決策的選擇都是十分複雜的,白袍高血壓或白袍效 應的觀念隨著醫院的文宣,民眾漸漸注意到這樣的現象也意識到求證真 實血壓與適當用藥的重要性。研究中多數個案表示從新陳代謝科門診轉 介至糖尿病諮詢門診,接受相關知識的教育與宣導後除了學會正確服用 藥物,也因為了解必須從運動跟飲食雙管齊下控制糖尿病的觀念,許多
中高齡的個案表示有主動建立自己的運動習慣,因工作無法定期運動的 年輕個案也表示會在飲食上對自己有所限制,這已有別以往國人面對糖 尿病時態度消極的印象,也肯定了糖尿病諮詢室在衛生教育宣導上的功 勞,確實獲得了病患正面的迴響與配合。
我們期望能夠從推行個案自我血壓監測的動作,教育個案以固定的 儀器、固定的肢體、固定的時間或情境以及固定的姿勢測量血壓,建立 對自己居家血壓數值的概念,以利門診時提供醫師作為與臨床血壓值差 別的比較,並初步作為白袍高血壓或白袍效應的參考,倘使對於疑似有 白袍效應或白袍高血壓之個案,醫院能提供動態血壓測量儀的配套測量 做確實鑑別,將對個案血壓狀況的醫療給予更實質的幫助。糖尿病史大 於五年的個案,若能由醫院單位會同研究單位執行心率變異性與心血管 自主神經功能標準測試的評估,也將能提供更有利的證據,佐證藥物治 療的成效。
此外,本研究中許多反向白袍效應組的生理參數,如較大的腰圍 與腰臀比,偏高的三酸甘油酯數值、總膽固醇數值是代謝症候群的危險 因子,再整合上述數值該族群似乎也有肥胖的傾向,若加上較差的動脈 硬化指數,是否也應將反向白袍效應列入與心血管疾病、標的器官傷害 等有關的考量?本研究目前未能有從研究中以足夠的證據來證實反向
白袍效應在心血管相關疾病或代謝相關疾病的致病機轉,但我們臆測反 向白袍效應與這類疾病應具有某種程度的關聯。此外,比較不同疾病類 別有白袍效應或反向白袍效應族群在自主神經功能的表現,也將是一個 等待探究的領域。
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