國立成功大學「邁向頂尖大學計畫」
延攬優秀人才工作報告表
NCKU’s “Aim for the Top University Project” Work Report Form for Distinguished Scholars □續聘continuation of employment 離職resignation
100 年 7 月 13 日更新
受聘者姓名
Name of the Employee
Subramanian Selvakumar 沙古瑪 男 女 Male Female 聘 期 Period of Employment from 2013 年(y) 08 月(m) 01 日(d) to 2013 年(y) 10 月(m) 11 日(d) 研究或教學或科技研發與 管理計畫名稱
The project title of research, teaching, technology development and management
工學院亮點計畫 計畫主持人 （申請單位主管） Project Investigator (Head of Department/Center) 化工系鄧熙聖教授 補助延聘編號
Grant Number HUA 102-3-3-339
一、研究、教學、科技研發與管理工作全程經過概述。（由受聘人填寫）
Please summarize the entire research, teaching, or science and technology R&D and management work process (To be completed
by the employee)
The main aim of this work is to synthesize core-shell type up-conversion nanomaterials, which can provide combination of dual modal imaging (Optical and Magnetic Resonance Imaging) along with photodynamic cancer therapy.
Multimodal imaging with therapy is an emerging field of treating cancer with proper diagnosis and curing. Multimodal bio imaging is a new frontier in biology and medicine, which combines more than one imaging modality, such as optical, nuclear, ultrasound and magnetic resonance imaging (MRI). Each method has its unique properties of application for imaging the cancer cells. Optical imaging of cancer cells has a many advantage of tuneable colours, cellular level imaging, high sensitivity and spatial resolution by deep penetrating NIR radiation. At the same time obtaining anatomical and physiological details in-vivo is difficult task due to most of the emission wavelength region is in visible range, which is having absorption problem by tissues and other cellular materials. In the case of MRI, the depth of in vivo imaging and exceptional anatomic information will be a major benefit. So, high spatial resolution, sensitivity and depth of imaging in both in-vitro and in-vivo will be obtained in great details by combining both optical and MR imaging. To combine optical and MR imaging we have designed Gd doped NaYF4 type
conversion nanoparticles with various combination of Gd to Y ratio to get the maximum up-converted emission. Normally, NaYF4 type of up-conversion structure will be used for optical
imaging, but in our combination of Gd doped NaYF4 type, we can expect optical imaging along
with T1 weighted MR imaging. Since Gd atom with seven un-paired electrons will be an efficient MRI contrast agent used in clinical study of cancer diagnosis. Moreover doping of Gd in the NaYF4 structure is expected to improve ultra violet up converted emission. The construction of
high UV emissive nanoparticle serve as an in-situ agent for the production of ultra violet ray
which normally used to excite electons in the semiconductor materials, TiO2, from valence band to
conduction band. This excitation leads to production of electrons and holes pair, which is an efficient reactive oxygen species (ROS) producer. To coat semiconducting TiO2 material over
UCNPs we have followed the strategy of coating mesoporous silica followed by coating of titania layer. The main aim of coating mesoporous silica layer over oleic acid coated up-conversion nanoparticle is to get the high surface area which can accommodate incoming titania coating uniformly. Moreover the silica layer will make UCNPs water dispersable, which is a primary condition for bio application, than oleic acid coated UCNPs. In addition, mesoporous coating serve a porous layer which will allow water molecule to contact inner Gd containing UCNPs to get good MR imaging. From our strategy we are able to excite the nano materials with highly penetrating NIR light for exciting UCNPs. The excited UCNPs will emit UV, visible and NIR radiation. The emitted visible and NIR radiation will be used for optical imaging of cancer cells and UV emission will be served to excite semi conducting TiO2 outer layer for photodynamic
therapy. In addition the presence of Gd will serve to perform MR imaging.
In conclusion, the optimization study of synthesis of high UV emissive UCNP and uniform coating of m-SiO2 followed by TiO2 is completed. The NIR mediated in-vitro and in-vivo study of
dual modal imaging and PDT with optimized core-shell type materials will need to be done in future.
二、研究或教學或科技研發與管理成效評估（由計畫主持人或單位主管填寫）
Please evaluate the performance of research, teaching or science and technology R&D and management Work: ( To be completed
by Project Investigator or Head of Department/Center) (1)是否達到延攬預期目標？
Has the expected goal of recruitment been achieved? 是，有達到預期目標。
(2)研究或教學或科技研發與管理的方法、專業知識及進度如何？
What are the methods, professional knowledge, and progress of the research, teaching, or R&D and management work?
The employee was involved to develop a material, which can be useful for multimodal imaging along with photodynamic therapy. The materials construction and characterization was done successfully and it is about to ready for further clinical trial.
(3)受延攬人之研究或教學或科技研發與管理成果對該計畫(或貴單位)助益如何？
How have the research, teaching, or R&D and management results of the employed person given benefit to the project (or your unit)? 可提升國際交流與跨領域合作機會。
(4)受延攬人於補助期間對貴單位或國內相關學術科技領域助益如何？
How has the employed person, during his or her term of employment, benefited your unit or the relevant domestic academic field? 可提升國際交流與跨領域合作機會。
(5)具體工作績效或研究或教學或科技研發與管理成果：
Please describe the specific work performance, or the results of research, teaching, or R&D and management work:
In the project to develop novel basic materials for photodynamic platform with optical and MRI imaging, a high emission intensity up conversion type materials was obtained and characterized thoroughly for size, optical, charge and elemental composition using TEM, UV-Vis , XRD, Zeta potential and ICP.
Following the synthesis of multimodal imagable materials, a coating layer with biocompatibility, nontoxic and able to produce photodynamic therapy was done and characterized properly. The
successfully synthesized core-shell type materials will be subjected to in vitro and in vivo studies. (6)是否續聘受聘人? Will you continue hiring the employed person? □續聘Yes 不續聘No
否，該學者有其生涯規劃。
※此報告表篇幅以三～四頁為原則。This report form should be limited to 3-4 pages in principle.
※此表格可上延攬優秀人才成果報告繳交說明網頁下載。
This report form can be downloaded in http://scholar.lib.ncku.edu.tw/explain/
