研究結果 4.1 第一階段學童氣喘調查
4.2 第二階段- 尿液檢體 8-OHdG 分析
本研究共收集208個尿液樣本，其中81位病例組及127位對照組之樣本進行分析。病 例組的尿中8-OHdG濃度為5.97 ug/g creatinine，對照組為6.16 ug/g creatinine，但兩者未 達統計上的顯著差異。
討論
從第一階段的問卷結果分析，以曾被醫師診斷為氣喘做為評定之標準，則男生氣喘 盛行率為 17.7%，女性氣喘盛行率 11.5%，比過去 1974 至 2002 年針對台北市學童進行 之氣喘盛行率調查高，且有逐年增加的趨勢（25,37,91,93,94）。
另外，在過敏性鼻炎部分，男童「曾經由醫師診斷有過敏性鼻炎的疾病」盛行率高 達 58.81%，比女生 47.13%高。過敏性鼻炎盛行率較高，推測可能的原因是台北市的氣 候屬於較為潮濕的天氣型態，所以可能導致過敏性鼻炎的盛行率較高。在過敏性鼻炎與 氣喘的結果，都發現男生的盛行率都高於女性，具有性別差異的特性（gender
difference）。而造成性別差異的特性，目前尚未明瞭真正的原因，但在相關文獻都有相 似的結論（97）。在分析相關危險因子部分，母親懷孕期間抽菸，增加學童得到氣喘的 風險，且呈現劑量關係，且所增加的風險遠高於環境汙染物對於學童氣喘發生的危險 性。若居住的環境汙染程度越嚴重，則得到氣喘的勝算比也較高。
尿液中的 8-OHdG 可以反應 DNA 受損程度與修復的情形，會受到性別、年齡、生 活習慣等因素之影響。在許多研究發現，暴露化學物質、游離輻射等會使體內的 8-OHdG 上升。但因為氣喘疾病的複雜性，可能需要更多進一步資料的共同分析，以瞭解疾病與 氧化傷害的關係。
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