【11】證書號數:I496579 【45】公告日: 中華民國 104 (2015) 年 08 月 21 日 【51】Int. Cl.: A61K38/08 A61P35/00 (2006.01) (2006.01) A61K38/16 (2006.01) 發明 全 6 頁 【54】名 稱:類鋅手指胜肽、其表現質體、及包含其之醫藥組成物之用途
USES OF ZINC FINGER-LIKE PEPTIDE, EXPRESSION PLASMID THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
【21】申請案號:100124615 【22】申請日: 中華民國 100 (2011) 年 07 月 12 日 【11】公開編號:201302214 【43】公開日期: 中華民國 102 (2013) 年 01 月 16 日 【72】發 明 人: 張南山 (US) CHANG, NAN SHAN
【71】申 請 人: 國立成功大學 NATIONAL CHENG KUNG UNIVERSITY
臺南市東區大學路 1 號 【74】代 理 人: 吳冠賜;蘇建太
【56】參考文獻:
Nan-Shan Chang, “Naturally occurring peptide Zfra inactivates tumor suppressors by covalent binding: An act of Zfration”, http://www.google.com.tw/url?
sa=t&rct=j&q=&esrc=s&frm=1&source=web&cd=1&ved=0CDEQFjAA&url= http%3A%2F%2Fwww.dtic.mil%2Fcgi-bin%2FGetTRDoc%3FAD%
3DADA512651&ei=A0JFUvehHszNkgWkmYGYBg&usg=AFQjCNF2qt_JnbqG0v0 aGA2ofj2hZqhsHA。September 2009.
Subhan Dudekula1 et al., “Zfra is a small wizard in the
mitochondrial apoptosis”, AGING, December 2010, Vol.2 No.12, p.1023-1029.
Jean-Yun Chang1 et al., “Signaling from membrane receptors to tumor suppressor WW domain-containing oxidoreductase”,
Experimental Biology and Medicine 2010; 235: 796–804.
Li-Jin Hsu et al., “Zfra is an inhibitor of Bcl-2 expression and cytochrome c release from the mitochondria”, Cell Signal. 2008 Jul;20(7):1303-12.
Qunying Hong et al., “Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-κB, JNK1, p53 and WOX1 during stress response”, BMC Molecular Biology 2007, 8:50, p.1-17. Cerroni L, “Aberrant bcl-2 protein expression provides a possible mechanism of neoplastic cell growth in cutaneous basal-cell carcinoma.” J Cutan Pathol. 1994 Oct,21(5):398-403. Nakagawa K, “bcl-2 expression in epidermal keratinocytic
diseases.” Cancer.1994 Sep 15,74(6):1720-4.
-圖 3B 係實施例 3 中控制組老鼠每天的腫瘤體積曲線-圖。