應用與建議

第六章結論與建議

第三節應用與建議

本研究的結果可以讓相關單位或工廠在制訂規範時做為參考的依據，並且建議為來的研究可以控制更多的相關干擾因子，以及增加研究的樣本數目，增加統計的效力。我們也建議未來的研究能夠著重於相關機制探討，以釐清噪音及化學物質共同暴露影響血壓及心跳速率的可能機制。最後也建議研究對象能夠盡量使用防護具，在疾病產生前做好萬全的預防。

參考文獻

(1) 彭燕淞，「中國文化大學碩士論文」，民國87年。

(2) 黃秀華、黃德琪。「合成皮業、泡綿業職業衛生現況調查分析研究」，

民國93 年。

(3) Fleming LE, Shalat SL, Redlich CA. Liver injury in workers exposed to dimethylformamide. Scand J Work Environ Health. 1990;16:289-92.

(4) Wang JD, Lai MY, Chen JS, Lin JM, Chiang JR, Shiau SJ, et al.

Dimethylformamide-induced liver damage among synthetic leather workers.

Arch Environ Health. 1991;46:161-6.

(5) Fiorito A, Larese F, Molinari S, Zanin T. Liver function alterations in synthetic leather workers exposed to dimethylformamide. Am J Ind Med.

1997;32:255-60.

(6) Luo JC, Kuo HW, Cheng TJ, Chang MJW. Abnormal liver function

associated with occupational exposure to dimethylformamide and hepatitis B virus. J Occup Environ Med. 2001;43:474-82.

(7) Saillenfait AM, Payan JP, Beydon D, Fabry JP, Langonne I, Sabate JP, et al. Assessment of the developmental toxicity, metabolism, and placental transfer of N, N-dimethylformamide administered to pregnant rats. Fundam Appl Toxicol. 1997;39:33-43.

(8) Fail PA, George JD, Grizzle TB, Heindel JJ. Formamide and

dimethylformamide: reproductive assessment by continuous breeding in mice.

Reprod Toxicol. 1998;12:317-32.

(9) Chang HY, Shih TS, Guo YL, Tsai CY, Hsu PC. Sperm function in

workers exposed to N, N-dimethylformamide in the synthetic leather industry.

Fertil Steril. 2004;81:1589-94.

(10)Lataye R, Campo P. Combined effects of a simultaneous exposure to noise and toluene on hearing function. Neurotoxicol Teratol. 1997;19:373-82.

(11) Wang VS, Shih TS, Chang HY, Lai JS, Lin CC. Evaluation of current biological exposure index for occupational N, N-dimethylformamide exposure from synthetic leather workers. J Occup Environ Med.

2004;46:729-36.

(12) Kuo HW, Huang YS, Lo JC, Cheng TJ, Chang Wu MJ. Exposure to solvents in a synthetic leather manufacturing plant. Int Arch Occup Environ Health. 2000;73:275-80.

(13) Chang HY, Shih TS, Cheng CC, Tsai CY, Lai JS, Wang VS. The effects of co-exposure to methyl ethyl ketone on the biological monitoring of

occupational exposure to N, N-dimethylformamide. Int Arch Occup Environ Health. 2003;76:121-8.

(14) Yang JS, Kim EA, Lee MY, Park IJ, Kang SK. Biological monitoring of occupational exposure to N, N-dimethylformamide – the effects of

co-exposure to toluene or dermal exposure. Int Arch Occup Environ Health.

2000;73:463-70.

(15) Willy PV, Wim FP. Noise exposure and public health. Environmental Health Perspectives 2000;108:123-131.

(16) 張錦松、韓光榮，「噪音振動控制」，高立圖書有限公司，2003。

(17) 張淑如、陳秋蓉、趙寶強、潘致弘、邱士剛：勞工聽力常模值之研究。勞工安全衛生研究季刊2001；9：199-209。

(18) 勞工安全衛生研究所：半導體工業作業人員噪音暴露狀況探討。勞工安全衛生檢訊第49 期。

(19)Coles RR, Knight JJ.Auditory hazards in a diesel engine test house.Ann Occup Hyg. 1960;2:267-73.

(20) McMahon KJ, McManus PE.Occupational noise exposure in the printing industry.Am Ind Hyg Assoc J. 1988;49:34-7.

(21)Helmkamp JC, Talbott EO, Margolis H.Occupational noise exposure and hearing loss characteristics of a blue-collar population.J Occup Med.1984;

26:885-91.

(22)Harger MR, Barbosa-Branco A.Effects on hearing due to the occupational noise exposure of marble industry workers in the Federal District, Brazil.Rev Assoc Med Bras.2004;50:396-9.

(23)Ahmed HO, Dennis JH, Badran O, Ismail M, Ballal SG, Ashoor A, Jerwood D.Occupational noise exposure and hearing loss of workers in two plants in eastern Saudi Arabia.Ann Occup Hyg.2001;45:371-80.

(24)Chin-Chen Wu, Shiu-Jen, Mao-Hsiung Yen. Effects of noise on blood pressure and vascular reactives.Clinical and Experimental Pharmacology and Physiology. 1992;19:833-838.

(25)Talbott EO, Gibson LB, Burks A, Engberg R, McHugh KP.Evidence for a dose-response relationship between occupational noise and blood pressure.

Arch Environ Health. 1999;54:71-8.

(26)Fouriad C, Jacquinet-Salord MC, Degoulet P, et al. Influence of socioprofessional conditions on blood pressure levels and hypertension control. Epidemiologic study of 6665 subjects in the Paris district. Am J Epidemiol. 1984;120:72-86.

(27)Tomei F, Fantini S, Tomao E, Baccolo TP, Rosati MV. Hypertension and chronic exposure to noise. Arch Environ Health. 2000;55:319-325.

(28)Abbate C, Giorgianni C, Munao F, Costa C, Brecciaroli R, Barbaro M.

Effects of noise on functional cardiovascular parameters: a follow-up study.G Ital Med Lav Ergon. 2002;24:43-8.

(29)Mahmood R, Khan GJ, Alam S, Safi AJ, Salahuddin, Amin-ul-Haq.

Effect of 90 decibel noise of 4000 hertz on blood pressure in young adults.J Ayub Med Coll Abbottabad. 2004;16:30-3.

(30)Fogari R, Zoppi A, Corradi L, Marasi G, Vanasia A, Zanchetti A.

Transient but not sustained blood pressure increments by occupational noise.

An ambulatory blood pressure measurement study. J Hypertens.

2001;19:1021-1027.

(31)Chang TY, Jain RM, Wang CS, Chan CC. Effects of occupational noise exposures on blood pressures. J Occup Environ Med. 2003;45:1289-1296.

(32)International Labour Organization.International Chemical Safety

Cards(ICSC).http://www.ilo.org/public/english/protection/safework/cis/produ cts/icsc/dtasht/index.htm. (cited on 3/24/06).

(33)Mraz J, Jheeta P, Gescher A, Hyland R, Thummel K, Threadgill MD.

Investigation of the mechanistic basis of N,N-dimethylformamide toxicity.

Metabolism of N,N-dimethylformamide and its deuterated isotopomers by cytochrome P450 2E1.Chem Res Toxicol. 1993;6:197-207.

(34)Kestell P, Gill MH, Threadgill MD, Gescher A, Howarth OW, Curzon EH.

Identification by proton NMR of N-(hydroxymethyl)-N-methylformamide as the major urinary metabolite of N,N-dimethylformamide in mice.Life Sci.

1986;38:719-24.

dimethylformamide in mice.Chem Biol Interact. 1983;45:387-92.

(36)Angerer J, Schildbach M, Kramer A.Gas chromatographic method for the simultaneous determination of S-p-toluylmercapturic acid and

S-phenylmercapturic acid in human urine. J Anal Toxicol. 1998;22:211-4.

(37)Fiorito A, Larese F, Molinari S, Zanin T.Liver function alterations in synthetic leather workers exposed to dimethylformamide.Am J Ind Med.

1997;32:255-60.

(38)Lyle WH, Spence TW, McKinneley WM, Duckers K.

Dimethylformamide and alcohol intolerance. Br J Ind Med. 1979;36:63-6.

(39)Hansen E, Meyer O.Embryotoxicity and teratogenicity study in rats dosed epicutaneously with dimethylformamide (DMF).J Appl Toxicol.

1990;10:333-8.

(40)Chang HY, Shih TS, Guo YL, Tsai CY, Hsu PC.Sperm function in workers exposed to N,N-dimethylformamide in the synthetic leather industry.

Fertil Steril. 2004;81:1589-94.

(41)ATSDR. Agency for Toxic Substance And Disease Registry.

Toxicological profile for toluene. US public health service.ATSDR/TP 89/23.1989.

(42)Tassaneeyakul W, Birkett DJ, Edwards JW, Veronese ME, Tassaneeyakul W, Tukey RH, Miners JO.Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene and o-, m- and p-xylene.J Pharmacol Exp Ther. 1996;276:101-8.

(43)Ladefoged O, Strange P, Moller A, Lam HR, Ostergaard G, Larsen JJ, Arlien-Soborg P.Irreversible effects in rats of toluene (inhalation) exposure for six months.Pharmacol Toxicol. 1991;68:384-90.

(44)Ungvary G, Tatrai E, Szeberenyi S, Rodics K, Lorincz M, Barcza G.

Effect of toluene exposure on the liver under different experimental conditions.Exp Mol Pathol. 1982;36:347-60.

(45)Benignus VA.Neurobehavioral effects of toluene: a review.Neurobehav Toxicol Teratol. 1981;3:407-15.

(46)Takeuchi Y, Hisanaga N, Ono Y, Ogawa T, Hamaguchi Y, Okamoto S.

Cerebellar dysfunction caused by sniffing of toluene-containing thinner.Ind Health. 1981;19:163-9.

(47)Abbate C, Giorgianni C, Munao F, Brecciaroli R.Neurotoxicity induced by exposure to toluene. An electrophysiologic study.Int Arch Occup Environ Health. 1993;64:389-92.

(48)Morata TC, Fiorini AC, Fischer FM, Colacioppo S, Wallingford KM, Krieg EF, Dunn DE, Gozzoli L, Padrao MA, Cesar CL.Toluene-induced hearing loss among rotogravure printing workers.Scand J Work Environ Health. 1997;23:289-98.

(49)Perbellini L, Brugnone F, Mozzo P, Cocheo V, Caretta D.Methyl ethyl ketone exposure in industrial workers. Uptake and kinetics.Int Arch Occup Environ Health. 1984;54:73-81.

(50)Liira J, Riihimaki V, Engstrom K, Pfaffli P.Coexposure of man to m-xylene and methyl ethyl ketone. Kinetics and metabolism.Scand J Work Environ Health. 1988;14:322-7.

(51)Liira J, Riihimaki V, Engstrom K.Effects of ethanol on the kinetics of methyl ethyl ketone in man. Br J Ind Med. 1990;47:325-30.

(52)Muttray A, Jung D, Klimek L, Kreiner C, Effects of an external exposure to 200 ppm methyl ethyl ketone on nasal mucosa in healthy volunteers.Int Arch Occup Environ Health. 2002;75:197-200.

metabolism, risk of alcoholism, and the role of alcohol and aldehyde dehydrogenase genotypes. J Lab Clin Med. 1993;122:234-240.

(54) Yin S-J. alcohol dehydrogenase: Enzymology and metabolism, In:

Saunders JB, Whitfield JB, eds. The biology of alcohol problem. Oxfort:

Elsevier Science, 1996.p113-119.

(55) Iwahashi K, Suwaki H. Ethanol metabolism, toxicity and genetic polymorphism. Addict Biol. 1998;3:249-259

(56) Christoph GR, Hansen JF, Leung HW.Subchronic inhalation neurotoxicity studies of ethyl acetate in rats.Neurotoxicology.2003;24:

861-874.

(57) Martinez TT, Jaeger RW, deCastro FJ.A comparison of the absorption and metabolism of isopropyl alcohol by oral, dermal and inhalation routes.

Vet Hum Toxicol. 1986;28:233-236.

(58) Ohashi Y, Nakai Y, Ikeoka H, Koshimo H, Esaki Y.Acute effects of isopropyl alcohol exposure on the middle ear mucosa.Journal of Applied Toxicology.1987;7:205-211.

(59) Vicas IM, Beck R.Fatal inhalational isopropyl alcohol poisoning in a neonate.J Appl Toxicol - Clinical Toxicology. 1993;31:473-481.

(60) Brayer C, Micheau P, Bony C, Tauzin L.Neonatal accidental burn by isopropyl alcohol.Arch Pediatr. 2004;11:932-935.

(61) Campo P, Lataye R, Cossec B, Placidi V.Toluene-induced hearing loss: a mid-frequency location of the cochlear lesions.Neurotoxicol Teratol.

1997;19:129-140.

(62) Kim J. Park H. Ha E. Jung T.Combined effects of noise and mixed solvents exposure on the hearing function among workers in the aviation industry.Ind Health. 2005;43:567-573.

(63) Morata TC, Dunn DE, Kretschmer LW.Effects of occupational exposure to organic solvents and noise on hearing.Scand J Work Environ

Health.1993;19:245-54.

(64) Sliwinska-Kowalska M. Zamyslowska-Szmytke E. Szymczak W.

Ototoxic effects of occupational exposure to styrene and co-exposure to styrene and noise.J Occup Environ Med. 2003;45:15-24.

(65) Ivanovich E, Antov G, Goranova L.Combined effect of some physical and chemical factors.J Hyg Epidemiol Microbiol Immunol. 1985;29:105-110.

(66) Wang JD, Lai MY, Chen JS.Dimethylformamide-induced liver damage among synthetic leather workers.Arch Environ Health.1991; 46:161-166.

(67) Fiorito A, Larese F, Molinari S.Liver function alterations in synthetic leather workers exposed to dimethylformamide.Am J Ind Med.

1997;32:255-260.

(68) Chang HY, Shih TS, Guo YL.Sperm function in workers exposed to N,N-dimethylformamide in the synthetic leather industry.Fertil Steril.

2004;81:1589-1594.

(69) Anna MF, Louis WC. Toxicology and risk assessment.1996;43:835-849.

(70)Estela KB et al. Acut and Chronic effect of noise exposure on blood pressure and heart rate among industrial employees: the cordis study. Arch Environ Health. 1995;50:298-304.

(71)Lang T, Fouriaud C. Length of occupational noise exposure and pressure.Int Arch Occup Environ Health. 1992;63:369-372.

(72) Andrén L, Hansson L, Björkman M, Jonsson A. Noise as a contributory factor in the development of elevated arterial pressure. Acta Med

Scand.1980;207:493-498.

Noise Exposure: Underlying Haemodynamic Mechanisms Specific to Passive Coping. Eur J Appl Physiol. 1993;67:367-374.

(74)Halimi F, Leclercq JF, Bacquet P. Hypertension and age over 70 years are the two most important risk factors for stroke in patients with atrial

fibrillation.Ann Cardiol Angeiol. 2004;53:18-22.

(75) Lloyd-Jones DM, Evans JC, Levy D. Hypertension in adults across the age spectrum: current outcomes and control in the community. JAMA.

2005;294:466-472.

(76)Wildman RP, Gu D. Muntner P, Huang G. Alcohol intake and hypertension subtypes in Chinese men. J Hypertens. 2005;23:737-43.

(77) Ohmori S, Kiyohara Y, Kato I. Alcohol intake and future incidence of hypertension in a general Japanese population: the Hisayama study. Clinical

& Experimental Research. 2002;26:1010-1016.

(78) Yamada Y. Alcohol consumption as a risk factor in the development of hypertension. Nippon Rinsho. 2004;62 Suppl 3:70-74.

(79)Sleight P. Smoking and hypertension. Clin Exp Hypertens.

1993;15:1181-1192.

(80) Williams MA, Mittendorf R, Monson RR. Chronic hypertension, cigarette smoking, and abruptio placentae. Epidemiology. 1991;2:450-453.

(81) Elliott JM, Simpson FO. Cigarettes and accelerated hypertension. New Zealand Medical Journal. 1980;91:447-449.

(82) Klag MJ, Wang NY, Meoni LA. Coffee intake and risk of hypertension:

the Johns Hopkins precursors study. Arch Intern Med. 2002;162:657-662.

(83) Geleijnse JM. Grobbee DE. Kok FJ. Impact of dietary and lifestyle factors on the prevalence of hypertension in Western populations. J Hum Hypertens. 2005;19 Suppl 3:S1-4.

(84) Freestone S, Yeo WW, Ramsay LE. Effect of coffee and cigarette smoking on the blood pressure of patients with accelerated (malignant) hypertension.J Hum Hypertens. 1995;9:89-91.

表1. 1、 30 位受測的健康基本資料與生活飲食習慣(不分組)

Resting SBP (mmHg)

Mean (SD) 126.86±18.47

Resting DBP (mmHg)

Mean (SD) 72.72±15.01

Total cholesterol

(mg/dL)

Mean (SD) 190.05±36.37

Triglyceride (mg/dL)

Mean (SD) 118.38±81.96

Regular exercise

Yes (%) 6(20.00％)

Alcohol consumption

Yes (%) 5(16.67％)

No (%) 25(83.33％)

Tea consumption

Yes (%) 17(56.67％)

No (%) 13(43.33％)

Coffee consumption

Yes (%) 12(40.00％)

No (%) 18(60.00％)

Hypertension family

Yes (%) 10(33.33％)

No (%) 20(66.67％)

表1. 2、30 位受測者分組後的健康基本資料與生活飲食習慣(噪音暴露)

Characteristics G1N G2N

Subjects (no.) 15 15

Age (years)

Mean (SD) 36.88±6.26 36.90±7.72

Body mass index

(kg/m

)

Mean (SD) 24.41±2.73* 23.81±3.20

Resting SBP (mmHg)

Mean (SD) 138.53±14.23* 117.68±16.10 Resting DBP (mmHg)

Mean (SD) 79.70±19.32* 67.23±6.38 Total cholesterol

(mg/dL)

Mean (SD) 202.35±31.96* 181.23±36.80 Triglyceride (mg/dL)

Mean (SD) 116.91±66.57 119.27±90.06 Regular exercise

Yes (%) 2(13.33％) 4(26.67％)

Alcohol consumption

Yes (%) 2(13.33％) 3(20.00％)

No (%) 13(86.67％) 12(80.00％)

Tea consumption

Yes (%) 8(53.33％) 9(60.00％)

No (%) 7(46.67％) 6(40.00％)

Coffee consumption

Yes (%) 3(20.00％) * 9(60.00％)

No (%) 12(80.00％) 6(40.00％)

Hypertension family

Yes (%) 5(33.33％) 5(33.33％)

No (%) 10(66.67％) 10(66.67％)

*達統計顯著 P＜0.05，

^†

達邊際顯著 P＜0.1

使用 t-test 分析不同組間的差異

使用卡方檢定及費歇爾精確檢定分析暴露組與非暴露組的差異

表1. 3、30 位受測者分組後的健康基本資料與生活飲食習慣(DMF 暴露)

Characteristics G1DMF G2DMF

Subjects (no.) 16 14

Age (years)

Mean (SD) 39.84±6.24* 34.11±6.76

Body mass index

(kg/m

)

Mean (SD) 25.53±2.52* 22.69±2.79

Resting SBP (mmHg)

Mean (SD) 134.61±15.82* 119.52±17.81 Resting DBP (mmHg)

Mean (SD) 76.00±15.39* 69.61±13.96 Total cholesterol

(mg/dL)

Mean (SD) 208.16±31.45* 172.61±32.02 Triglyceride (mg/dL)

Mean (SD) 172.65±88.19* 81.10±40.87 Regular exercise

Yes (%) 2(12.50％) 4(28.57％)

Alcohol consumption

Yes (%) 2(12.50％) 3(21.43％)

No (%) 14(87.50％) 11(78.57％)

Tea consumption

Yes (%) 7(43.75％) 10(71.43％)

No (%) 9(56.25％) 4(28.57％)

Coffee consumption

Yes (%) 3(18.75％) * 9(64.29％)

No (%) 13(81.25％) 5(35.71％)

Hypertension family

Yes (%) 6(37.50％) 4(28.57％)

No (%) 10(62.50％) 10(71.43％)

*達統計顯著 P＜0.05，

^†

達邊際顯著 P＜0.1

使用 t-test 分析不同組間的差異

使用卡方檢定及費歇爾精確檢定分析暴露組與非暴露組的差異

表1. 4、30 位受測者分組後的健康基本資料與生活飲食習慣(TOL 與 DMF 之共同暴露)

Characteristics G1TD G2TD

Subjects (no.) 16 14

Age (years)

Mean (SD) 38.89±8.03* 35.04±5.53

Body mass index

(kg/m

)

Mean (SD) 24.88±2.92* 23.32±2.91

Resting SBP (mmHg)

Mean (SD) 131.27±18.88* 122.77±17.11 Resting DBP (mmHg)

Mean (SD) 75.24±16.02* 70.38±13.61 Total cholesterol

(mg/dL)

Mean (SD) 199.42±38.25* 181.20±32.11 Triglyceride (mg/dL)

Mean (SD) 152.87±94.07* 97.81±57.14 Regular exercise

Yes (%) 2(12.50％) 4(28.573％)

Alcohol consumption

Yes (%) 2(12.50％) 3(21.43％)

No (%) 14(87.50％) 11(78.57％)

Tea consumption

Yes (%) 7(43.75％) 10(71.43)

No (%) 9(56.25％) 4(28.573％)

Coffee consumption

Yes (%) 2(12.50％) * 10(71.43)

No (%) 14(87.50％) 4(28.573％)

Hypertension family

Yes (%) 7(43.75％) 3(21.43％)

No (%) 9(56.25％) 11(78.57％)

*達統計顯著 P＜0.05，

^†

達邊際顯著 P＜0.1

使用 t-test 分析不同組間的差，

使用卡方檢定及費歇爾精確檢定分析暴露組與非暴露組的差異

表1. 5、30 位受測者分組後的健康基本資料與生活飲食習慣(全部有機溶劑之共同暴露)

Characteristics G1ALL G2ALL

Subjects (no.) 18 12

Age (years)

Mean (SD) 38.38±7.50* 34.93±6.03

Body mass index

(kg/m

)

Mean (SD) 25.19±2.80* 22.59±2.63

Resting SBP (mmHg)

Mean (SD) 131.07±17.36* 121.29±18.44 Resting DBP (mmHg)

Mean (SD) 74.42±14.85* 70.46±14.95 Total cholesterol

(mg/dL)

Mean (SD) 198.81±36.55* 178.09±32.55 Triglyceride (mg/dL)

Mean (SD) 161.32±87.18* 75.79±34.52 Regular exercise

Yes (%) 2(11.11％) 4(33.33％)

Alcohol consumption

Yes (%) 2(11.11％) 3(25.00％)

No (%) 16(8.89％) 9(75.00％)

Tea consumption

Yes (%) 8(44.44％) 9(75.00％)

No (%) 10(55.56％) 3(25.00％)

Coffee consumption

Yes (%) 3(16.67％) * 9(75.00％)

No (%) 15(83.33％) 3(25.00％)

Hypertension family

Yes (%) 7(38.89％) 3(25.00％)

No (%) 11(61.11％) 9(75.00％)

*達統計顯著 P＜0.05，

^†

達邊際顯著 P＜0.1

使用 t-test 分析不同組間的差異，

使用卡方檢定及費歇爾精確檢定分析暴露組與非暴露組的差異

表1. 6、30 位受測者分組後的健康基本資料與生活飲食習慣(噪音與 DMF 之共同暴露)

Characteristics G1N,DMF G2 N,DMF G3 N,DMF G1 N,DMF

Subjects (no.) 10 5 6 9

Age (years)

Mean (SD) 39.40±5.33* 32.46±5.25* 40.44±7.27* 34.85±7.22

Body mass index

(kg/m

)

Mean (SD) 25.10±2.75* 23.20±2.24 26.13±2.02* 22.46±2.98 Resting SBP (mmHg)

Mean (SD) 138.79±13.64* 138.08±15.25* 128.91±16.81* 111.17±11.42 Resting DBP (mmHg)

Mean (SD) 80.54±18.49* 78.23±20.07* 69.81±5.32* 65.73±6.48

Total cholesterol

(mg/dL)

Mean (SD) 214.06±32.02* 179.34±14.76 200.52±29.06* 170.04±36.22 Triglyceride (mg/dL)

Mean (SD) 192.26±113.23* 73.36±29.74 202.78±93.75* 84.06±44.07 Regular exercise

Yes (%) 1（10.00％） 1（20.00％） 1（16.67％） 3（33.33％）

Alcohol consumption

Yes (%) 1（10.00％） 1（20.00％） 1（16.67％） 2（22.22％）

No (%) 9（90.00％） 4（80.00％） 5（83.33％） 7（77.78％）

Tea consumption

Yes (%) 4（40.00％） 4（80.00％） 3（50.00％） 6（66.67％）

No (%) 6（60.00％） 1（20.00％） 3（50.00％） 3（33.33％）

Coffee consumption

Yes (%) 0（0.00％）* 3（60.00％） 3（50.00％） 6（66.67％）

No (%) 10（100.00％） 2（40.00％） 3（50.00％） 3（33.33％）

Hypertension family

Yes (%) 4（40.00％） 1（20.00％） 2（33.33％） 3（33.330％）

No (%) 6（60.00％） 4（80.00％） 4（66.67％） 6（66.67％）

*達統計顯著 P＜0.05，

^†

達邊際顯著 P＜0.1

使用 t-test 分析不同組間的差異，

使用費歇爾精確檢定分析暴露組與非暴露組的差異

表1. 7、30 位受測者分組後的健康基本資料與生活飲食習慣(噪音、TOL 及 DMF 之共同暴露)

Characteristics G1N,TD G2 N,TD G3 N,TD G4 N,TD

Subjects (no.) 9 6 7 8

Age (years)

Mean (SD) 39.87±5.71* 33.48±5.00* 37.97±9.65* 36.07±5.64 Body mass index

(kg/m

)

Mean (SD) 24.92±2.98* 23.83±2.29* 24.85±2.88* 22.98±3.21 Resting SBP (mmHg)

Mean (SD) 140.52±14.30* 136.27±13.84* 122.47±18.53* 113.91±12.70 Resting DBP (mmHg)

Mean (SD) 82.61±19.57* 76.39±18.55* 68.23±6.05 66.44±6.584 Total cholesterol

(mg/dL)

Mean (SD) 212.82±35.09* 189.64±21.84* 187.48±37.06* 176.32±35.91 Triglyceride (mg/dL)

Mean (SD) 136.86±71.49* 81.34±35.60 178.82±107.74* 77.01±36.68 Regular exercise

Yes (%) 1（11.11％） 1（16.67％） 1（14.29％） 3（37.50％）

No (%) 8（88.89％） 5（83.33％） 6（85.71％） 5（62.50％）

Activity

High (%) 4（44.44％） 2（33.33％） 3（42.86％） 5（62.50％）

Low (%) 5（55.56％） 4（66.67％） 4（57.14％） 3（37.50％）

Smoking

Yes (%) 6（66.67％）

^†

3（50.00％） 3（42.86％） 2（25.00％）

No (%) 3（33.33％） 3（50.00％） 4（57.14％） 6（75.00％）

Alcohol consumption

Yes (%) 1（11.11％） 1（16.67％） 1（14.29％） 2（25.00％）

No (%) 8（88.89％） 5（83.33％） 6（85.71％） 6（75.00％）

Tea consumption

Yes (%) 4（44.44％） 4（66.67％） 3（42.86％） 6（75.00％）

No (%) 5（55.56％） 2（33.33％） 4（57.14％） 2（25.00％）

Coffee consumption

Yes (%) 0（0.00％）* 3（50.00％） 2（28.57％）* 7（87.50％）

No (%) 9（100.00％） 3（50.00％） 5（71.43％） 1（12.50％）

Hypertension family

Yes (%) 4（44.44％） 1（16.67％） 3（42.86％） 2（25.00％）

No (%) 5（55.56％） 5（83.33％） 4（57.14％） 6（75.00％）

*達統計顯著 P＜0.05，

^†

達邊際顯著 P＜0.1

使用 t-tes 分析不同組間的差異，

使用費歇爾精確檢定分析暴露組與非暴露組的差異

表1. 8、30 位受測者分組後的健康基本資料與生活飲食習慣(噪音與全部有機溶劑之共同暴露)

Characteristics G1N,ALL G2 N,ALL G3 N,ALL G4 N,ALL

Subjects (no.) 10 5 8 7

Age (years)

Mean (SD) 39.40±5.33* 32.46±5.25* 37.38±9.03 36.39±6.00

Body mass index

(kg/m

)

Mean (SD) 25.10±2.75* 23.20±2.24* 25.29±2.86* 22.23±2.77 Resting SBP (mmHg)

Mean (SD) 138.79±13.64* 138.08±15.25* 123.57±17.32* 111.39±11.82 Resting DBP (mmHg)

Mean (SD) 80.54±18.49* 78.23±20.70* 68.49±5.63 65.89±6.87

Total cholesterol

(mg/dL)

Mean (SD) 214.06±32.02* 179.34±14.76 184.77±34.84 177.46±38.50 Triglyceride (mg/dL)

Mean (SD) 137.38±71.53* 79.71±32.55 178.82±107.74* 77.01±36.68 Regular exercise

Yes (%) 1（10.00％） 1（20.00％） 1（12.50％） 3（37.50％）

Alcohol consumption

Yes (%) 1（10.00％） 1（20.00％） 1（12.50％） 2（28.57％）

No (%) 9（90.00％） 4（80.00％） 7（87.50％） 5（71.43％）

Tea consumption

Yes (%) 4（40.00％） 4（80.00％） 4（50.00％） 5（71.43％）

No (%) 6（60.00％） 1（20.00％） 4（50.00％） 2（28.57％）

Coffee consumption

Yes (%) 0（0.00％）* 3（60.00％） 3（27.50％）

^†

6（85.71％）

No (%) 10（100.00％） 2（40.00％） 5（82.50％） 1（14.29％）

Hypertension family

Yes (%) 4（40.00％） 1（20.00％） 3（37.50％） 2（71.43％）

No (%) 6（60.00％） 4（80.00％） 5（82.50％） 5（28.57％）

*達統計顯著 P＜0.05，

^†

達邊際顯著 P＜0.1

使用 t-tes 分析不同組間的差異，

使用費歇爾精確檢定分析暴露組與非暴露組的差異

表2. 1、研究對象在上班時間、下班時間、睡覺時間及全天 24 小時，其收縮壓、舒

Off-Duty Time (6:00 PM-11:00PM)

Sleep Time (11:00 PM-8:00 AM)

表2. 2、不同暴露分組在上班時間、下班時間、睡覺時間及全天 24 小時，其收縮壓、

Off-Duty Time (6:00 PM-11:00PM)

Sleep Time (11:00 PM-8:00 AM)

表2. 3、不同暴露分組在上班時間、下班時間、睡覺時間及全天 24 小時，其收縮壓、

Off-Duty Time (6:00 PM-11:00PM)

Sleep Time (11:00 PM-8:00 AM)

表2. 4、不同暴露分組在上班時間、下班時間、睡覺時間及全天 24 小時，其收縮壓、

Off-Duty Time (6:00 PM-11:00PM)

Sleep Time (11:00 PM-8:00 AM)

The TLV of Mixtures G1TD

表2. 5、不同暴露分組在上班時間、下班時間、睡覺時間及全天 24 小時，其收縮壓、

Off-Duty Time (6:00 PM-11:00PM)

Sleep Time (11:00 PM-8:00 AM)

The TLV of Mixtures G1ALL

表2. 6、不同暴露分組在上班時間、下班時間、睡覺時間及全天 24 小時，其收縮壓、

Sleep Time (11:00 PM-8:00 AM)

24-Hour Average SBP(mmHg)^a

G1N,DMF (no.) 138.62±16.75 (116)* 136.14±15.68(49) 125.81±19.33(64) 134.51±18.08 (229)*

G2 N,DMF (no.) 138.50±15.94 (62)* 139.21±15.33 (34)* 126.64±22.20(36) 135.45±18.40 (132)*

G3 N,DMF (no.) 136.62±18.31 (73)^† 137.57±18.66(49) 129.61±16.13(46) 134.98±19.05(168) G4 N,DMF (no.) 122.90±15.85(145) 124.98±15.46(80) 116.56±13.42(68) 121.99±15.48(293) DBP(mmHg)^a

G1N,DMF (no.) 79.55±14.53(116) 79.76±14.50(49) 69.61±12.40(64) 76.82±14.61(229)

G2 N,DMF (no.) 82.45±12.90 (62)* 80.94±11.63(34) 73.17±13.51(36) 79.53±13.26 (132)*

表2. 7、不同暴露分組在上班時間、下班時間、睡覺時間及全天 24 小時，其收縮壓、 (6:00 PM-11:00PM)

Sleep Time (11:00 PM-8:00 AM)

24-Hour Average SBP(mmHg)^a

G1N,TD (no.) 141.00±16.41(97)* 138.87±16.09(39)* 128.02±19.64(55) 136.83±18.16(191)*

G2 N,TD (no.) 135.68±16.06(81)* 136.09±15.06(44)* 123.78±21.06(45) 132.64±18.00(170)*

G3 N,TD (no.) 127.87±19.98(93) 132.47±20.41(58)* 122.57±18.26(53) 127.80±19.92(204)*

G4 N,TD (no.) 127.21±16.23(125) 127.55±15.07(71) 121.18±13.58(61) 125.87±15.49(257)

DBP(mmHg)^a

G1N,TD (no.) 85.98±17.19(97)* 80.28±10.02(39)* 72.31±14.91(55) 80.88±16.34(191)*

G2 N,TD (no.) 81.30±13.34(81)* 80.32±12.93(44)* 68.93±14.14(45) 77.77±14.40(170)†

G3 N,TD (no.) 78.26±15.90(93)† 83.33±17.67(58)* 75.21±16.45(53) 78.91±16.76(204)*

G4 N,TD (no.) 76.12±12.99(125) 75.31±9.75(71) 70.67±11.31(61) 74.60±11.94(257)

HR(BPM)^a

G1N,TD (no.) 76.79±12.94(97) 76.56±14.30(39) 68.56±12.95(55) 74.38±13.67(191)

G2 N,TD (no.) 85.07±13.98(81)* 83.50±11.63(44)^† 73.73±12.30(45) 81.66±13.77(170)*

G3 N,TD (no.) 77.13±12.24(93) 78.74±13.12(58) 70.60±14.05(53) 75.89±13.31(204)

G4 N,TD (no.) 76.18±12.17(125) 75.68±11.91(71) 68.51±14.40(61) 74.22±13.01(257)

Noise(dBA)^b

G1N,TD (no.) 81.64±6.32(969)* 67.23±15.69(540) 47.03±12.66(972) NA

G2 N,TD (no.) 81.22±9.38(633)* 64.14±20.28(360) 43.23±10.67(648) NA

G3 N,TD (no.) 74.88±11.01(754) 58.16±17.14(420) 40.45±10.15(756) NA

G4 N,TD (no.) 73.20±12.22(853) 58.34±17.01(477) 47.31±13.91(864) NA

The TLV of

表2. 8、不同暴露分組在上班時間、下班時間、睡覺時間及全天 24 小時，其收縮壓、 (6:00 PM-11:00PM)

Sleep Time (11:00 PM-8:00 AM)

24-Hour Average SBP(mmHg)^a

G1N,ALL (no.) 138.62±16.75(161)* 136.14±15.68(49) 125.81±19.33(64) 134.51±18.08(229)

G2 N,ALL (no.) 138.50±15.94(62)* 139.21±15.33(34)^† 126.64±22.20(36) 135.45±18.40(132)*

G3 N,ALL (no.) 129.37±19.67(107) 131.51±19.04(68) 124.19±17.76(62) 128.63±19.13(237)

G4 N,ALL (no.) 125.68±15.86(111) 127.80±16.16(61) 119.00±12.87(52) 124.71±15.59(224)

DBP(mmHg)^a

G1N,ALL (no.) 83.82±16.80(161)* 78.84±10.00(49) 71.39±14.08(64) 79.28±15.69(229)

G2 N,ALL (no.) 83.90±13.49(62)* 82.41±13.43(34) 69.72±15.62(36) 79.65±15.26(132)

G3 N,ALL (no.) 79.36±15.36(107)^† 82.32±16.57(68) 75.52±15.51(62) 79.21±15.89(237)

G4 N,ALL (no.) 74.78±12.88(111) 75.11±10.35(61) 69.52±11.42(52) 73.65±12.07(224)

HR(BPM)^a

G1N,ALL (no.) 79.55±14.53(161) 79.76±14.50(49) 69.61±12.40(64) 76.82±14.61(229)

G2 N,ALL (no.) 82.45±12.90(62)* 80.94±11.63(34) 73.17±13.51(36) 79.53±13.26(132)

G3 N,ALL (no.) 77.20±11.61(107) 76.94±13.30(68) 69.50±13.60(62) 75.11±13.03(237)

G4 N,ALL (no.) 75.99±12.74(111) 77.18±11.68(61) 69.46±15.05(52) 74.80±13.32(224)

Noise(dBA)^b

G1N,ALL (no.) 81.17±6.63(1078)* 63.39±18.39(600) 45.42±12.41(1080) NA

G2 N,ALL (no.) 81.97±9.75(524)* 68.87±17.67(300) 45.19±11.11(540) NA

G3 N,ALL (no.) 74.96±11.96(867) 54.81±17.77(480) 40.05±9.74(864) NA

G4 N,ALL (no.) 72.87±11.46(740) 62.10±15.38(417) 48.98±14.19(756) NA

The TLV of

表3.1.1、相關危險因子在上班時間對於研究對象動態血壓跟心跳的影響(不分組)

SBP(mmHg) DBP(mmHg) HR(BPM) Models β±Seβ P value β±Seβ P value β±Seβ P value Age (years) 0.33±0.19 0.10^† 0.10±0.15 0.53 -0.40±0.13 ＜0.01*

Body mass index (kg/m²) 1.47±0.46 ＜0.01* 0.72±0.36 0.06^† 0.10±0.32 0.74 Smoke (yes/no) 8.82±2.66 ＜0.01* 7.15±2.08 ＜0.01* 5.41±1.82 ＜0.01*

Alcohol (yes/no) -1.44±3.63 0.70 -1.38±2.83 0.63 -1.06±2.48 0.67 Tea (yes/no) -3.23±2.73 0.25 -2.00±2.14 0.36 -2.80±1.87 0.15 Coffee (yes/no) 1.25±2.88 0.67 1.22±2.25 0.59 0.08±1.97 0.97 Hypertension family (yes/no) 3.24±3.54 0.37 0.73±2.77 0.80 -0.78±2.42 0.75 Active (yes/no) -5.09±2.72 0.08^† -5.68±2.13 0.01* 1.31±1.86 0.49 Regexercise (yes/no) -7.02±3.59 0.06^† -2.79±2.81 0.33 0.62±2.46 0.80

*達統計顯著 P＜0.05，

^†

達邊際顯著 P＜0.1。使用混合式線性迴歸調整員工的年齡、BMI、抽煙習慣、

喝酒習慣、喝茶習慣、喝咖啡習慣、家族性高血壓病史、活動量和運動習慣。

表3.1. 2、相關危險因子在下班時間對於研究對象之動態血壓跟心跳的影響(不分組)

SBP(mmHg) DBP(mmHg) HR(BPM) Models β±Seβ P value β±Seβ P value β±Seβ P value Age (years) 0.48±0.23 0.05^† 0.27±0.18 0.16 -0.24±0.23 0.31 Body mass index (kg/m²) 0.77±0.57 0.19 0.64±0.45 0.17 -0.37±0.55 0.51 Smoke (yes/no) 6.10±3.36 0.08^† 5.99±2.67 0.04* 6.43±3.25 0.06^† Alcohol (yes/no) -1.49±4.46 0.74 1.53±3.54 0.67 0.17±4.33 0.97 Tea (yes/no) -3.10±3.29 0.36 -4.57±2.61 0.10^† -6.63±3.17 0.05^† Coffee (yes/no) 2.20±3.61 0.55 3.96±2.86 0.18 1.91±3.51 0.59 Hypertension family (yes/no) 6.16±4.44 0.18 -0.60±3.51 0.87 0.26±4.26 0.95 Active (yes/no) -7.79±3.35 0.03* -5.07±2.66 0.07^† 1.48±3.25 0.65 Regexercise (yes/no) 4.15±4.33 0.35 -1.56±3.42 0.65 2.56±4.16 0.55

*達統計顯著 P＜0.05，

^†

達邊際顯著 P＜0.1。使用混合式線性迴歸調整員工的年齡、BMI、抽煙習慣、

喝酒習慣、喝茶習慣、喝咖啡習慣、家族性高血壓病史、活動量和運動習慣。

表3.1. 3、相關危險因子在睡覺時間對於研究對象之動態血壓跟心跳的影響(不分組)

SBP(mmHg) DBP(mmHg) HR(BPM) Models β±Seβ P value β±Seβ P value β±Seβ P value Age (years) 0.08±0.31 0.80 0.07±0.25 0.79 -0.09±0.23 0.69 Body mass index (kg/m²) 0.09±0.75 0.90 0.37±0.59 0.53 -0.77±0.54 0.17 Smoke (yes/no) 14.29±4.43 ＜0.01* 11.37±3.49 ＜0.01* 8.20±3.22 0.02*

Alcohol (yes/no) -1.42±5.93 0.81 3.26±4.67 0.49 -2.36±4.31 0.59 Tea (yes/no) -5.50±4.24 0.21 -3.19±3.34 0.35 -7.13±3.09 0.03*

Coffee (yes/no) 8.73±4.90 0.09^† 6.27±3.86 0.12 8.19±3.57 0.03*

Hypertension family (yes/no) -8.75±5.73 0.14 -5.33±4.51 0.25 -6.24±4.17 0.15 Active (yes/no) -1.51±4.51 0.74 -4.17±3.55 0.25 -0.38±3.28 0.91 Regexercise (yes/no) 5.67±5.47 0.31 0.04±4.31 0.99 6.63±3.98 0.11

*達統計顯著 P＜0.05，

^†

達邊際顯著 P＜0.1。使用混合式線性迴歸調整員工的年齡、BMI、抽煙習慣、

喝酒習慣、喝茶習慣、喝咖啡習慣、家族性高血壓病史、活動量和運動習慣。

表3.1. 4、相關危險因子在全天 24 小時對於研究對象之動態血壓跟心跳的影響(不分組)

SBP(mmHg) DBP(mmHg) HR(BPM) Models β±Seβ P value β±Seβ P value β±Seβ P value Age (years) 0.40±0.56 0.48 -0.21±0.52 0.69 -0.44±0.42 0.30 Body mass index (kg/m²) 1.14±1.29 0.39 1.62±1.89 0.19 -0.02±0.95 0.98 Smoke (yes/no) 11.02±7.96 0.18 8.67±7.32 0.25 -0.88±5.90 0.88 Alcohol (yes/no) -1.11±10.96 0.92 -0.56±10.07 0.96 -2.33±8.12 0.78 Tea (yes/no) 2.15±7.72 0.78 -1.91±7.09 0.79 5.46±5.73 0.35 Coffee (yes/no) -4.21±8.99 0.64 8.43±8.26 0.32 -7.16±6.65 0.29 Hypertension family (yes/no) 10.33±10.02 0.32 -3.71±9.20 0.69 -0.11±7.43 0.99 Active (yes/no) -13.14±8.10 0.12 -8.43±7.44 0.27 -6.50±6.01 0.29 Regexercise (yes/no) -11.69±9.94 0.25 7.16±9.12 0.44 -5.04±7.38 0.50

*達統計顯著 P＜0.05，

^†

達邊際顯著 P＜0.1。使用混合式線性迴歸調整員工的年齡、BMI、抽煙習慣、

喝酒習慣、喝茶習慣、喝咖啡習慣、家族性高血壓病史、活動量和運動習慣。

表3.2. 1、不同暴露族群及相關危險因子在上班時間對於動態血壓跟心跳的影響(噪音暴露)

SBP(mmHg) DBP(mmHg) HR(BPM) Models β±Seβ P value β±Seβ P value β±Seβ P value G1N vs. G2N 11.51±2.79 ＜0.01* 6.83±2.28 ＜0.01* 3.99±2.06 0.07^† Age (years) 0.42±0.18 0.03* 0.15±0.15 0.32 -0.36±0.13 0.01*

Body mass index (kg/m²) 1.65±0.43 ＜0.01 0.83±0.35 0.03* 0.16±0.31 0.61 Smoke (yes/no) 4.57±2.65 0.10^† 4.58±2.16 0.05^† 3.93±1.95 0.06^† Alcohol (yes/no) -3.86±3.37 0.27 -2.82±2.75 0.32 -1.87±2.48 0.46 Tea (yes/no) -4.36±2.52 0.10^† -2.67±2.06 0.21 -3.22±1.86 0.10^† Coffee (yes/no) 8.04±3.10 0.02* 5.21±2.53 0.05^† 2.41±2.29 0.31 Hypertension family (yes/no) 2.37±3.25 0.47 0.19±2.65 0.94 -1.12±2.40 0.65 Active (yes/no) -4.67±2.49 0.08^† -5.43±2.04 0.02* 1.46±1.84 0.44 Regexercise (yes/no) -7.72±3.29 0.03* -3.15±2.69 0.26 -0.81±2.43 0.74

*達統計顯著 P＜0.05，

^†

達邊際顯著 P＜0.1。使用混合式線性迴歸調整員工的年齡、BMI、抽煙習慣、

喝酒習慣、喝茶習慣、喝咖啡習慣、家族性高血壓病史、活動量和運動習慣。

表3.2. 2、不同暴露族群及相關危險因子在下班時間對於動態血壓跟心跳的影響(噪音暴露)

SBP(mmHg) DBP(mmHg) HR(BPM) Models β±Seβ P value β±Seβ P value β±Seβ P value G1N vs. G2N 8.09±3.52 0.03* 1.26±2.92 0.67 4.90±3.52 0.18 Age (years) 0.56±0.23 0.02* 0.28±0.19 0.15 -0.18±0.23 0.42 Body mass index (kg/m²) 0.84±0.55 0.14 0.65±0.46 0.17 -0.30±0.55 0.59 Smoke (yes/no) 3.72±3.41 0.29 5.62±2.83 0.06^† 4.96±3.43 0.17 Alcohol (yes/no) -2.19±4.31 0.62 1.43±3.59 0.69 -0.26±4.35 0.95 Tea (yes/no) -3.63±3.18 0.27 -4.67±2.64 0.09^† -6.97±3.19 0.04*

Coffee (yes/no) 6.60±3.97 0.11 4.64±3.30 0.18 4.60±4.02 0.27 Hypertension family (yes/no) 4.86±4.33 0.28 -0.82±3.58 0.82 -0.42±4.30 0.92 Active (yes/no) -7.14±3.24 0.04* -4.96±2.70 0.08^† 1.83±3.27 0.58 Regexercise (yes/no) -4.44±4.18 0.30 -1.59±3.47 0.65 2.23±4.17 0.60

*達統計顯著 P＜0.05，

^†

達邊際顯著 P＜0.1。使用混合式線性迴歸調整員工的年齡、BMI、抽煙習慣、

喝酒習慣、喝茶習慣、喝咖啡習慣、家族性高血壓病史、活動量和運動習慣。

表3.2. 3、不同暴露族群及相關危險因子在睡覺時間對於動態血壓跟心跳的影響(噪音暴露)

SBP(mmHg) DBP(mmHg) HR(BPM) Models β±Seβ P value β±Seβ P value β±Seβ P value G1N vs. G2N 0.46±4.67 0.32 -3.56±3.68 0.35 0.78±3.45 0.82 Age (years) 0.13±0.32 0.69 0.03±0.25 0.90 -0.09±0.24 0.72 Body mass index (kg/m²) 0.19±0.75 0.81 0.31±0.59 0.61 -0.76±0.56 0.19 Smoke (yes/no) 12.75±4.68 0.01* 12.53±3.68 ＜0.01* 7.92±3.46 0.03*

Alcohol (yes/no) -1.85±5.95 0.76 3.58±4.68 0.45 -2.45±4.39 0.58 Tea (yes/no) -5.72±4.25 0.19 -3.03±3.35 0.38 -7.16±3.14 0.03*

Coffee (yes/no) 11.34±5.54 0.05^† 4.31±4.36 0.34 8.64±4.09 0.05^† Hypertension family (yes/no) -9.05±5.74 0.13 -5.11±4.52 0.27 -6.31±4.24 0.15 Active (yes/no) -1.39±4.51 0.76 -4.26±3.55 0.25 -0.36±3.33 0.92 Regexercise (yes/no) 4.88±5.54 0.39 0.63±4.36 0.89 6.51±4.09 0.13

*達統計顯著 P＜0.05，

^†

達邊際顯著 P＜0.1。使用混合式線性迴歸調整員工的年齡、BMI、抽煙習慣、

喝酒習慣、喝茶習慣、喝咖啡習慣、家族性高血壓病史、活動量和運動習慣。

表3.2. 4、不同暴露族群及相關危險因子在全天 24 小時對於動態血壓跟心跳的影響(噪音暴露)

SBP(mmHg) DBP(mmHg) HR(BPM) Models β±Seβ P value β±Seβ P value β±Seβ P value G1N vs. G2N -3.55±8.89 0.69 1.35±8.19 0.87 -2.18±6.61 0.30 Age (years) 0.37±0.58 0.53 -0.20±0.53 0.72 -0.46±0.43 0.75 Body mass index (kg/m²) 1.07±1.33 0.43 1.65±1.23 0.20 -0.06±0.99 0.95 Smoke (yes/no) 12.22±8.68 0.18 8.21±8.00 0.32 -0.15±6.44 0.98 Alcohol (yes/no) -0.86±11.23 0.94 -0.65±10.35 0.95 -2.19±8.33 0.80 Tea (yes/no) 2.51±7.95 0.76 -2.04±7.33 0.78 5.66±5.91 0.35 Coffee (yes/no) -6.11±10.35 0.56 9.15±9.54 0.35 -8.32±7.67 0.29 Hypertension family (yes/no) 10.53±10.26 0.32 -3.79±9.46 0.69 0.02±7.62 1.00 Active (yes/no) -13.35±8.31 0.13 -8.35±7.66 0.29 -6.63±6.17 0.30 Regexercise (yes/no) -10.97±10.32 0.30 -7.44±9.51 0.44 -4.59±7.68 0.56

*達統計顯著 P＜0.05，

^†

達邊際顯著 P＜0.1。使用混合式線性迴歸調整員工的年齡、BMI、抽煙習慣、

喝酒習慣、喝茶習慣、喝咖啡習慣、家族性高血壓病史、活動量和運動習慣。

表3.3. 1、不同暴露族群及相關危險因子在上班時間對於動態血壓跟心跳的影響(DMF 暴露)

SBP(mmHg) DBP(mmHg) HR(BPM) Models β±Seβ P value β±Seβ P value β±Seβ P value G1DMF vs. G2DMF 3.59±3.99 0.37 4.07±3.10 0.20 1.42±2.73 0.61 Age (years) 0.29±0.20 0.17 0.04±0.16 0.78 -0.41±0.14 ＜0.01*

Body mass index (kg/m²) 1.32±0.49 0.01* 0.56±0.38 0.16 0.04±0.34 0.90 Smoke (yes/no) 7.16±3.23 0.04* 5.27±2.52 0.05^† 4.75±2.22 0.05^† Alcohol (yes/no) -1.94±3.67 0.60 -1.95±2.85 0.50 -1.26±2.51 0.62 Tea (yes/no) -2.70±2.79 0.35 -1.40±2.18 0.53 -2.60±1.92 0.19 Coffee (yes/no) 2.58±3.24 0.44 2.73±2.52 0.29 0.61±2.22 0.79 Hypertension family (yes/no) 3.29±3.54 0.36 0.78±2.76 0.78 -0.77±2.43 0.76 Active (yes/no) -5.50±2.77 0.06^† -6.14±2.15 0.01* 1.14±1.89 0.55 Regexercise (yes/no) -7.44±3.62 0.05^† -3.26±2.82 0.26 -0.78±2.48 0.76

*達統計顯著 P＜0.05，

^†

達邊際顯著 P＜0.1。使用混合式線性迴歸調整員工的年齡、BMI、抽煙習慣、

喝酒習慣、喝茶習慣、喝咖啡習慣、家族性高血壓病史、活動量和運動習慣。

表3.3. 2、不同暴露族群及相關危險因子在下班時間對於動態血壓跟心跳的影響(DMF 暴露)

SBP(mmHg) DBP(mmHg) HR(BPM) Models β±Seβ P value β±Seβ P value β±Seβ P value G1DMF vs. G2DMF -0.67±4.84 0.89 2.31±3.80 0.55 0.98±4.70 0.84 Age (years) 0.49±0.24 0.06^† 0.24±0.19 0.22 -0.25±0.24 0.31 Body mass index (kg/m²) 0.80±0.62 0.21 0.53±0.49 0.29 -0.41±0.59 0.49 Smoke (yes/no) 6.38±4.02 0.13 4.98±3.16 0.13 6.01±3.89 0.14 Alcohol (yes/no) -1.38±4.58 0.77 1.18±3.60 0.75 0.02±4.46 1.00 Tea (yes/no) -3.22±3.42 0.36 -4.22±2.68 0.13 -6.50±3.31 0.07^† Coffee (yes/no) 1.96±4.03 0.63 4.77±3.17 0.15 2.26±3.95 0.57 Hypertension family (yes/no) 6.13±4.50 0.19 -0.55±3.53 0.88 0.26±4.33 0.95 Active (yes/no) -7.73±3.42 0.04* -5.25±2.69 0.07^† 1.41±3.33 0.68 Regexercise (yes/no) -4.01±4.46 0.38 -1.95±3.50 0.59 2.42±4.31 0.58

*達統計顯著 P＜0.05，

^†

達邊際顯著 P＜0.1。使用混合式線性迴歸調整員工的年齡、BMI、抽煙習慣、

喝酒習慣、喝茶習慣、喝咖啡習慣、家族性高血壓病史、活動量和運動習慣。

表3.3. 3、不同暴露族群及相關危險因子在睡覺時間對於動態血壓跟心跳的影響(DMF 暴露)

SBP(mmHg) DBP(mmHg) HR(BPM) Models β±Seβ P value β±Seβ P value β±Seβ P value

在文檔中噪音與有機溶劑之共同暴露對合成皮業勞工的動態血壓及心跳速率影響之研究 (頁 112-200)

第六章 結論與建議

第三節 應用與建議

Resting SBP (mmHg)

Mean (SD) 126.86±18.47

Resting DBP (mmHg)

Mean (SD) 72.72±15.01

Total cholesterol

(mg/dL)

Mean (SD) 190.05±36.37

Triglyceride (mg/dL)

Mean (SD) 118.38±81.96

Regular exercise

Yes (%) 6(20.00％)

Alcohol consumption

Yes (%) 5(16.67％)

No (%) 25(83.33％)

Tea consumption

Yes (%) 17(56.67％)

No (%) 13(43.33％)

Coffee consumption

Yes (%) 12(40.00％)

No (%) 18(60.00％)

Hypertension family

Yes (%) 10(33.33％)

No (%) 20(66.67％)

Subjects (no.) 15 15

Age (years)

Mean (SD) 36.88±6.26 36.90±7.72

Body mass index

(kg/m

)

Mean (SD) 24.41±2.73* 23.81±3.20

Resting SBP (mmHg)

Mean (SD) 138.53±14.23* 117.68±16.10 Resting DBP (mmHg)

Mean (SD) 79.70±19.32* 67.23±6.38 Total cholesterol

(mg/dL)

Mean (SD) 202.35±31.96* 181.23±36.80 Triglyceride (mg/dL)

Mean (SD) 116.91±66.57 119.27±90.06 Regular exercise

Yes (%) 2(13.33％) 4(26.67％)

Alcohol consumption

Yes (%) 2(13.33％) 3(20.00％)

No (%) 13(86.67％) 12(80.00％)

Tea consumption

Yes (%) 8(53.33％) 9(60.00％)

No (%) 7(46.67％) 6(40.00％)

Coffee consumption

Yes (%) 3(20.00％) * 9(60.00％)

No (%) 12(80.00％) 6(40.00％)

Hypertension family

Yes (%) 5(33.33％) 5(33.33％)

No (%) 10(66.67％) 10(66.67％)

*達統計顯著 P＜0.05，

達邊際顯著 P＜0.1

使用 t-test 分析不同組間的差異

使用卡方檢定及費歇爾精確檢定分析暴露組與非暴露組的差異

Subjects (no.) 16 14

Age (years)

Mean (SD) 39.84±6.24* 34.11±6.76

Body mass index

(kg/m

)

Mean (SD) 25.53±2.52* 22.69±2.79

Resting SBP (mmHg)

Mean (SD) 134.61±15.82* 119.52±17.81 Resting DBP (mmHg)

Mean (SD) 76.00±15.39* 69.61±13.96 Total cholesterol

(mg/dL)

Mean (SD) 208.16±31.45* 172.61±32.02 Triglyceride (mg/dL)

Mean (SD) 172.65±88.19* 81.10±40.87 Regular exercise

Yes (%) 2(12.50％) 4(28.57％)

Alcohol consumption

Yes (%) 2(12.50％) 3(21.43％)

No (%) 14(87.50％) 11(78.57％)

Tea consumption

Yes (%) 7(43.75％) 10(71.43％)

No (%) 9(56.25％) 4(28.57％)

Coffee consumption

Yes (%) 3(18.75％) * 9(64.29％)

No (%) 13(81.25％) 5(35.71％)

Hypertension family

第六章結論與建議

第三節應用與建議