• 沒有找到結果。

第六章 結論與未來展望

6.2 未來展望

本論文之表面電漿子生物感測器,採用 Biosensing Instruments 公司之 商業化儀器 BI-3000G,系統主要以桌上型與電腦連線為主,本論文已完成 了檢測金膜的優化。由於表面電漿子共振系統龐大,若希望提升 SPR 檢測 的便利性,只研發靈敏度更高的檢測金膜是不夠的,因此,未來我們的目 標將朝著可攜式以及單次檢測即丟的方向前進。

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參考文獻

[1] R. W. Wood, “XLII. On a remarkable case of uneven distribution of light in a diffraction grating spectrum,” Phil. Mag., 4, 396 (1902).

[2] A. Sommerfeld, “Über die Ausbreitung der Wellen in der drahtlosen Telegraphie,” Annalen der Physik, 333, 665 (1909).

[3] A. Otto, “Excitation of Nonradiative Surface Plasma Waves in Silver by the Method of Frustrated Total Reflection,” Z. Phys., 216, 398 (1968).

[4] E. Kretschmann, “Die bestimmung optischer Konstanten von Metallen durch Anregung von Oberflachen plasmaschwingungen,” Z. Phys., 241, 313 (1971).

[5] J. Homola, S. S. Yee, and G. Gauglitz, “Surface plasmon resonance sensors: review,” Sensors and Actuators B., 54, 3 (1999).

[6] W. L. Barnes, A. Dereux, and T. W. Ebbesen, “Surface plasmon subwavelength optics,” Nature, 424, 824 (2003).

[7] S. G. Nelson, K. S. Johnston, and S. S. Yee, “High sensitivity surface plasmon resonance sensor based on phase detection,” Sensors and Actuators B: Chemical, 35, 187 (1996).

[8] J. Homola, “Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species,” Chem. Rev., 108, 462 (2008).

[9] E. Stenberg, B. Persson, H. Roos, and C. Urbaniczky, “Quantitative determination of surface concentration of protein with surface plasmon resonance using radiolabeled proteins”, Journal of colloid and interface science, 143, 513 (1991).

[10] E. Hutter, J. H. Fendler, and D. Roy, “Surface Plasmon Resonance Studies of Gold and Silver Substrates by 2-Aminoethanethiol and

96

1,6-Hexanedithiol,” J. Phys. Chem. B., 105, 11159 (2001).

[11] B. Liedberg, C. Nylander, and I. Lunström, “Surface plasmon resonance for gas detection and biosensing,” Sensors and Actuators, 4, 299 (1983).

[12] I. Langmuir, “The constitution and fundamental properties of solids and liquids. II. Liquids,” J. Am. Chem. Soc., 39, 1848 (1917).

[13] W. C. Bigelow, D. L Pickett, and W. A. Zisman, “Oleophobic monolayers:

I. Films adsorbed from solution in non-polar liquids,” Journal of Colloid Science., 1, 513 (1946).

[14] R. G. Nuzzo and D. L. Allara, “Adsorption of bifunctional organic disulfides on gold surfaces,” J. Am. Chem. Soc., 105, 4481 (1983).

[15]

H. Sellers, A. Ulman, Y. Shnidman, and J. E. Eilers, “Structure and binding of alkanethiolates on gold and silver surfaces: implications for self-assembled monolayers,” J. Am. Chem. Soc., 115, 9389 (1993).

[16]

A. Ulman, “Formation and Structure of Self-Assembled Monolayers,”

Chem. Rev., 96, 1533 (1996).

[17] S. Löfås and B. Johnsson, “A novel hydrogel matrix on gold surfaces in surface plasmon resonance sensors for fast and efficient covalent immobilization of ligands,” J. Chem. Soc., Chem. Commun., 21, 1526 (1990).

[18] R. G. Nuzzo, F. A. Fosco, and D. L. Allara, “Spontaneously organized molecular assemblies. 3. Preparation and properties of solution adsorbed monolayers of organic disulfides on gold surfaces,” J. Am. Chem. Soc., 109, 2358 (1987).

[19] M. D. Porter, T. B. Bright, D. L. Allara, and C. E. D. Chidsey,

“Spontaneously organized molecular assemblies. 4. Structural

97

characterization of n-alkyl thiol monolayers on gold by optical ellipsometry, infrared spectroscopy, and electrochemistry,” J. Am. Chem.

Soc., 109, 3559 (1987).

[20] B. Johnsson, S. Löfås, G. Lindquist, A. Edström, R. M. M. Hillgren, and A.

Hansson, “Comparison of methods for immobilization to carboxymethyl dextran sensor surfaces by analysis of the specific activity of monoclonal antibodies,” J. Mol. Recognit., 8, 125 (1995).

[21] B. Johnsson, S. Löfås, and G. Lindquist, “Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors,” Anal. Biochem., 198, 268 (1991).

[22] A. K. Geim, “Graphene: Status and Prospects,” Science, 324, 1530 (2009).

[23] A. Geim and K. Novoselov, “For groundbreaking experiments regarding the two-dimensional material graphene,” The Nobel Prize in Physics (2010). http://www.nobelprize.org/nobel_prizes/physics/laureates/2010/

[24] C. S. Shan, H. F. Yang, J. F. Song, D. X. Han, A. Ivaska, and L.

Niu, “Direct Electrochemistry of Glucose Oxidase and Biosensing for Glucose Based on Graphene,” Anal. Chem., 81, 2378 (2009).

[25] W. Lv, M. Guo, M. H. Liang, F. M. Jin, L. Cui, L. J. Zhi, and Q. H. Yang,

“Graphene-DNA hybrids: self-assembly and electrochemical detection performance,” J. Mater. Chem., 20, 6668 (2010).

[26] L. Wu, H. S. Chu, W. S. Koh, and E. P. Li, “Highly sensitive graphene biosensors based on surface plasmon resonance,” Optics Express, 18, 14395 (2010).

[27] H. Raether, “Surface Plasmons on Smooth and Rough Surfaces and on Gratings,” Springer Tracts in Modern Physics., 111, ISBN:

98

978-3-540-17363-2 (1988).

[28] R. R. Nair, P. Blake, A. N. Grigorenko, K. S. Novoselov, T. J. Booth, T.

Stauber, N. M. R. Peres, and A. K. Geim, “Fine structure constant defines visual transparency of graphene,” Science, 320, 1308 (2008).

[29] S. H. Choi, Y. L. Kim, and K. M. Byun, “Graphene-on-silver substrates for sensitive surface plasmon resonance imaging biosensors,” Optics Express, 19, 458 (2011).

[30] O. Salihoglu, S. Balci, and C. Kocabas, “Plasmon-polaritons on graphene-metal surface and their use in biosensors,” Appl. Phys. Lett., 100, 213110 (2012).

[31] X. S. Li, W. W. Cai, J. H. An, S. Y. Kim, J. H. Nah, D. X. Yang, R. Piner, A.

Velamakanni, I. Jung, E. Tutuc, S. K. Banerjee, L. Colombo, and R. S.

Ruoff, “Large-Area Synthesis of High-Quality and Uniform Graphene Films on Copper Foils,” Science, 324, 1312 (2009).

[32] D. R. Dreyer, S. J. Park, C. W. Bielawski and R. S. Ruoff, “The chemistry of graphene oxide,” Chem. Soc. Rev., 39, 228 (2010).

[33] X. Sun, Z. Liu, K. Welsher, J. T. Robinson, A. Goodwin, S. Zaric, and H.

Dai, “Nano-graphene oxide for cellular imaging and drug delivery,” Nano Res., 1, 203 (2008).

[34] Z. Liu, J. T. Robinson, X. Sun, and H. Dai, “PEGylated nano-graphene oxide for delivery of water insoluble cancer drugs,” J. Am. Chem. Soc., 130, 10876 (2008).

[35] C. H. Lucas, A. J. L. Peinado, J. de D. L. González, M. L. R. Cervantes, and R. M. M. Aranda, “Study of oxygen-containing groups in a series of graphite oxides: Physical and chemical characterization,” Carbon, 33, 1585 (1995).

99

[36] F. Liu, J. Y. Choi, and T. S. Seo, “Graphene oxide arrays for detecting specific DNA hybridization by fluorescence resonance energy transfer,”

Biosens Bioelectron, 25, 2361 (2010).

[37] Y. Hu, F. H. Li, X. X. Bai, D. Li, S. C. Hua, K. K. Wang, and L. Niu,

“Label-free electrochemical impedance sensing of DNA hybridization based on functionalized graphene sheets,” Chem. Commun., 47, 1743 (2011).

[38] M. R. Kagan and R. L. McCreery, “Reduction of fluorescence interference in Raman spectroscopy via analyte adsorption on graphitic carbon,” Anal.

Chem., 66, 4159 (1994).

[39] Z. Liu, Q. Liu, Y. Huang, Y. Ma, S. Yin, X. Zhang, W. Sun, and Y. Chen,

“Organic photovoltaic devices based on a novel acceptor material:

graphene,” Adv. Mater., 20, 3924 (2008).

[40] S. He, B. Song, D. Li, C. Zhu, W. Qi, Y. Wen, L. Wang, S. Song, H. Fang, and C. Fan, “A graphene nanoprobe for rapid, sensitive, and multicolor fluorescent DNA analysis,” Adv. Funct. Mater., 20, 453 (2010).

[41] C. H. Lu, H. H. Yang, C. L. Zhu, X. Chen, and G. N. Chen, “A graphene platform for sensing biomolecules,” Angew. Chem. Int. Ed., 48, 4785 (2009).

[42] S. Myung, A. Solanki, C. Kim, J. Park, K. S. Kim, and K. B. Lee,

“Graphene-Encapsulated Nanoparticle-Based Biosensor for the Selective Detection of Cancer Biomarkers,” Adv. Mater., 23, 2221 (2011).

[43] A. Citri and Y. Yarden, “EGF-ERBB signalling: towards the systems level,”

Nat. Rev. Mol. Cell Biol., 7, 505 (2006).

[44] F. Patolsky, G. F. Zheng, and C. M. Lieber, “Fabrication of silicon nanowire devices for ultrasensitive, label-free, real-time detection of

100

biological and chemical species,” Nat. Protoc., 1, 1711 (2006).

[45] World Health Organization (WHO), “Global Tuberculosis Report 2012.”

http://apps.who.int/iris/bitstream/10665/75938/1/9789241564502_eng.pdf [46] K. N. Olivier, D. J. Weber, R. J. J. Wallace, A. R. Faiz, J. H. Lee, Y. Zhang,

B. A. Brown-Elliot, A. Handler, R. W. Wilson, M. S. Schechter, L. J.

Edwards, S. Chakraborti, and M. R. Knowles, “Nontuberculous mycobacteria. I: Multicenter prevalence study in cystic fibrosis,” Am. J.

Respir. Crit. Care Med., 167, 828 (2003).

[47] T. Notomi1, H. Okayama, H. Masubuchi1, T. Yonekawa, K. Watanabe1, N.

Amino, and T. Hase, “Loop-mediated isothermal amplification of DNA,”

Nucleic Acids Res., 28, e63 (2000).

[48] T. Iwamoto, T. Sonobe1, and K. Hayashi, “Loop-mediated isothermal amplification for direct detection of mycobacterium tuberculosis complex, M. avium, and M. intracellulare in sputum samples,”

J. Clin. Microbiol., 41, 2616 (2003).

[49] M. Caws, S. M. Wilson, C. Clough, and F. Drobniewski, “Role of IS6110-targeted PCR, culture, biochemical, clinical, and immunological criteria for diagnosis of tuberculous meningitis,” J. Clin. Microbiol., 38, 3150 (2000).

[50] L. Kohan, M. H. Shahhosseiny, M. R. Razavi, K. Parivar, E. Moslemi, and J. Werngren, “Evaluation of loop mediated isothermal amplification for diagnosis of Mycobacterium tuberculosis complex in clinical samples,”

Afr. J. Biotech., 10, 5096 (2011).

[51] I. K. Neonakis, D. A. Spandidos, and E. Petinaki, “Use of loop-mediated isothermal amplification of DNA for the rapid detection of Mycobacterium tuberculosis in clinical specimens,” Eur. J. Clin. Microbiol. Infect. Dis., 30,

101

937 (2011).

[52] Y. M. Hale, G. E. Pfyffer, and M. Salfinger, “Laboratory diagnosis of mycobacterial infections: new tools and lessons learned,” Clin. Infect Dis., 33, 834 (2001).

[53] H. Soini and J. M. Musser, “Molecular diagnosis of mycobacteria,” Clin Chem., 47, 809 (2001).

[54] G. L. Woods, “Molecular methods in the detection and identification of mycobacterial infections,” Arch. Pathol. Lab Med., 123, 1002 (1999).

[55] S. Y. Lee, J. G. Huang, T. L. Chuang, J. C. Sheu, Y. K. Chuang, M. Holl, D.

R. Meldrum, C. N. Lee, and C. W. Lin, “Compact optical diagnostic device for isothermal nucleic acids amplification,” Sensors and Actuators B, 133, 493 (2008).

[56] B. R. Eing, A. Becker, A. Sohns, and R. Ringelmann, “Comparison of roche cobas amplicor mycobacterium tuberculosis assay with in-house PCR and culture for detection of M. tuberculosis,” J. Clin. Microbiol., 36, 2023 (1998).

[57] T. J. Hellyer, T. W. Fletcher, J. H. Bates, W. W. Stead, G. L. Templeton, M.

D. Cave, and K. D. Eisenach, “Strand displacement amplification and the polymerase chain reaction for monitoring response to treatment in patients with pulmonary tuberculosis,” J. Infect. Dis., 173, 934 (1996).

[58] E. Aryan, M. Makvandi, A. Farajzadeh, K. Huygen, P. Bifani, S. L.

Mousavi, A. Fateh, A. Jelodar, M. M. Gouya, and M. Romano, “A novel and more sensitive loop-mediated isothermal amplification assay targeting IS6110 for detection of Mycobacterium tuberculosis complex,” Microbio.

Res., 165, 211 (2010).

[59] S. C. Hsieh, C. C. Chang, C. C. Lu, C. F. Wei, C. S. Lin, H. C. Lai, and C.

102

W. Lin, “Rapid identification of Mycobacterium tuberculosis infection by a new array format-based surface plasmon resonance method,” Nanoscale Res. Lett., 7, 180 (2012).

[60] C. C. Boehme, P. Nabeta, G. henostroza, R. Raqib, Z. Rahim, M. Gerhardt, E. Sanga, M. Hoelscher, T. Notomi, T. Hase, and M. D. Perkins,

“Operational feasibility of using loop mediated isothermal amplification for diagnosis of pulmonary tuberculosis in microscopy center of developing countries,” J. Clin. Microbiol., 45, 1936 (2007).

[61] B. D. Pandey , A. Poudel, T. Yoda, A. Tamaru, N. Oda, Y. Fukushima, B.

Lekhak, B. Risal, B. Acharya, B. Sapkota, C. Nakajima, T. Taniguchi, B.

Phetsuksiri, and Y. Suzuki, “Development of an in-house loopmediated isothermal amplification (LAMP) assay for detection of Mycobacterium tuberculosis and evaluation in sputum samples of Nepalese patients,” J.

Med. Microbiol., 57, 439 (2008).

[62] R. Y. Zhu, K. X. Zhang, M. Q. Zhao, Y. H. Liu, Y. Y. Xu, C. M. Ju, B. Li, and J. D. Chen, “Use of visual loop mediated isothermal amplification of rimM sequence for rapid detection of Mycobacterium tuberculosis and Mycobacterium bovis,” J. Microbiol. Methods., 78, 339 (2009).

[63] D. G. Myszka, “Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors,” Current Opinion in Biotechnology, 8, 50, (1997).

[64] R. J. Green, R. A. Frazier, K. M. Shakesheff, M. C. Davies, C. J. Roberts, and S. J. B. Tendler, “Surface plasmon resonance analysis of dynamic biological interactions with biomaterials,” Biomaterials, 21, 1823 (2000).

[65] L. P. Lin, L. S. Huang, C. W. Lin, C. K. Lee, J. L. Chen, S. M. Hsu, and S.

Lin, “Determination of binding constant of DNA-binding drug to target

103

DNA by surface plasmon resonance biosensor technology,” Curr. Drug Targets Immune. Endocr. Metabol. Disord., 5, 61 (2005).

[66] Biosensing Instrument Inc., “BI-3000 SPR System User’s Manual (Version 2.0.4),” (2009). http://www.BiosensingUSA.com/

[67] D. G. Myszka, T. A. Morton, M. L. Doyle, and I. M. Chaiken, “Kinetic analysis of a protein antigen-antibody interaction limited by mass transport on an optical biosensor” Biophysical Chemistry, 64, 127 (1997).

[68] D. A. Brevnov, H. O. Finklea, and H. V. Ryswyk, “Ac voltammetry studies of electron transfer kinetics for a redox couple attached via short alkanethiols to a gold electrode,” J. Electroanalytical Chem., 500, 100 (2001).

[69] C. C. Chang, N. F. Chiu, D. S. Lin, Y. C. Su, Y. H. Liang, and C. W. Lin,

“High-Sensitivity Detection of Carbohydrate Antigen 15-3 Using a Gold/Zinc Oxide Thin Film Surface Plasmon Resonance-Based Biosensor,”

Anal. Chem., 82, 1207 (2010).

[70] H. Zhou, X. Wang, P. Yu, X. Chen, and L. Mao, “Sensitive and selective voltammetric measurement of Hg2+ by rational covalent functionalization of graphene oxide with cysteamine,” Analyst, 137, 305 (2012).

[71] H. Zhang, Y. Sun, S. Gao, J. Zhang, H. Zhang, and D. Song, “A Novel Graphene Oxide-Based Surface Plasmon Resonance Biosensor for Immunoassay,” Small, DOI: 10.1002/smll.201202958 (2013).

[72] J. Zhang, Y. Sun, B. Xu, H. Zhang, Y. Gao, H. Zhang, and D. Song, “A novel surface plasmon resonance biosensor based on graphene oxide decorated with gold nanorod–antibody conjugates for determination of transferrin,” Biosens Bioelectron., 45, 230 (2013).

[73] D. C. Carter and J. X. Ho, “Structure of serum albumin,” Adv. Protein

104

Chem., 45, 153 (1994).

[74] W. C. Tsai and I. C. Lin, “Development of a piezoelectric immunosensor for the detection of alpha-fetoprotein,” Sensors and Actuators B, 106, 455 (2005).

[75] X. Su, F. T. Chew, and S. F. Y. Li, “Self-Assembled Monolayer-Based Piezoelectric Crystal Immunosensor for the Quantification of Total Human Immunoglobulin E,” Anal Biochem., 273, 66 (1999).

[76] S. F. Chou, W. L. Hsu, J. M. Hwang, and C. Y. Chen, “Development of an immunosensor for human ferritin, a nonspecific tumor marker, based on surface plasmon resonance,” Biosens Bioelectron., 19, 999 (2004).

[77] G. K. Ramesha and S. Sampath, “Electrochemical Reduction of Oriented Graphene Oxide Films: An in Situ Raman Spectroelectrochemical Study,”

J. Phys. Chem. C., 113, 7985 (2009).

[78] P. Wagner, M. Hegner, H. J. Guntherodt, and G. Semenza, “Formation and in Situ Modification of Monolayers Chemisorbed on Ultraflat Template-Stripped Gold Surfaces,” Langmuir, 11, 3867 (1995).

[79] M. J. E. Fischer, “Amine coupling through EDC/NHS: a practical approach,” Methods Mol Biol., DOI: 10.1007/978-1-60761-670-2_3 (2010).

[80] A. Kausaite, M. V. Dijk, J. Castrop, A. Ramanaviciene, J. P. Baltrus, J.

Acaite, and A. Ramanavicius, “Surface Plasmon Resonance Label-free Monitoring of Antibody Antigen Interactions in Real Time,” Biochem Mol Biol Educ., 35, 57 (2007).

[81] C. Q. Xiao, F. L. Jiang, B. Zhou, R. Li, and Y. Liu, “Interaction between a cationic porphyrin and bovine serum albumin studied by surface plasmon resonance, fluorescence spectroscopy and cyclic voltammetry,” Photochem

105

Photobiol Sci., 10, 1110 (2011).

[82] G. Eda and M. Chhowalla, “Chemically Derived Graphene Oxide, Towards Large-Area Thin-Film electronics and Optoelectronics,” Adv.

Mater., 22, 2392 (2010).

[83] Z. Wang, S. Wu, J. Zhang, P. Chen, G. Yang, X. Zhou, Q. Zhang, Q. Yan and H. Zhang, “Comparative studies on single-layer reduced graphene oxide films obtained by electrochemical reduction and hydrazine vapor reduction,” Nanoscale Res. Lett., 7, 161 (2012).

[84] T. Kono, R. Savan, M. Sakai, and T. Itami, “Detection of white spot syndrome virus in shrimp by loop-mediated isothermal amplification,” J Virol Methods., 115, 59-65 (2004).

[85] D. Thierry, M. D.Cave, K. D.Eisenach, J. T.Crawford, J. H.Bates, B.

Gicquel, and J. L.Guesdon, “IS6110, an IS-like element of Mycobacterium tuberculosis complex,” Nucleic Acids Research., 18, 188 (1990).

[86] A. P. Mortari and R. P. Bucy, “In situ hybridization with digoxigenin-labeled RNA probes: facts and artifacts,” Biotechniques., 18, 300 (1995).

[87] J. Chevalier, J. Yi, O. Michel, and X. M. Tang, “Biotin and Digoxigenin as labels for light and electron microscopy in situ hybridization probe: Where do we stand?,” J. Histochem. Cytochem., 45, 481 (1997).

[88] N. L. Ge, K. M. Kocan, G. L. Murphy, and E. F. Blouin, “Detection of anaplasma marginale DNA in bovine erythrocyte by slot-blot and in situ hybridization with a PCR-mediated digoxigenin-labeled DNA probe,” J.

Vet. Diagn. Invest., 7, 465, (1995).

[89] J. Zhang, Y. Sun, B. Xu, H. Zhang, Y. Gao, H. Zhang, and D. Song, “A novel surface plasmon resonance biosensor based on graphene oxide

106

decorated with gold nanorod-antibody conjugates for determination of transferrin,” Biosens Bioelectron., 45, 230 (2013).