第四章 結果
V. 期刊中以四物湯加減方治療的疾病分析
三、 國外文獻對四物湯之研究
由於國際上對四物湯之英文名字無特別規定，所以四物湯的英文名稱在國 外期刊都不統一，如“Si Wu Tang”、 “Si Wu decoction”、 “four-agents-decoction”、
“Shimotsu-to” 等。以 “Si Wu Tang” 為關鍵詞查詢 Pudmed 資料庫，初步搜尋 Pudmed 資料庫得到 12 篇題名含 “Si Wu Tang” 的文獻。以 “Si Wu decoction”
為關鍵詞查詢得4 筆、以 “four-agents-decoction” 為關鍵詞查詢得 2 筆，但前兩 者皆包含在 “Si Wu Tang” 的範疇。若以 “Shimotsu-to” 為關鍵詞查詢可得 10 筆，有部分文獻與 “Si Wu Tang” 重複。經整理刪除題名無以上英文名詞者，共 得25 篇文獻，其年度分佈自 1991~2009 年（2009 年之期刊截取至 5 月）。按照 最新出版年份排序條列如下：
1. Yeh, L.L., J.Y. Liu, Y.S. Liu, K.S. Lin, T.F. Tsai, L.H. Wang：Anemia-related hemogram, uterine artery pulsatility index, and blood pressure for the effects of Four-Agents-Decoction (Si Wu Tang) in the treatment of primary dysmenorrhea，J Altern Complement Med， 2009. 15(5): p. 531-8.
2. Wang, Z.J., S.K. Wo, L. Wang, C.B. Lau, V.H. Lee, M.S. Chow, Z. Zuo：
Simultaneous quantification of active components in the herbs and products of Si-Wu-Tang by high performance liquid chromatography-mass spectrometry，J Pharm Biomed Anal， 2009. 50(2): p. 232-44.
3. Zeng, H.P., T.T. Wang, W. Chen, C.Y. Wang, D.F. Chen, J.G. Shen： Characterization of chemical components in extracts from Si-wu decoction with proliferation-promoting effects on rat mesenchymal stem cells，Bioorg Med Chem， 2008. 16(9): p. 5109-14.
4. Liang, Q.D., Y. Gao, H.L. Tan, P. Guo, Y.F. Li, Z. Zhou, W. Tan, Z.C. Ma, B.P.
Ma, S.Q. Wang：Effects of four Si-Wu-Tang's constituents and their combination on irradiated mice，Biol Pharm Bull， 2006. 29(7): p. 1378-82.
5. Chang, C.J., J.H. Chiu, L.M. Tseng, C.H. Chang, T.M. Chien, C.C. Chen, C.W.
Wu, W.Y. Lui：Si-Wu-Tang and its constituents promote mammary duct cell proliferation by up-regulation of HER-2 signaling，Menopause， 2006. 13(6): p.
967-76.
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6. Sheng, Y.X., L. Li, Q. Wang, H.Z. Guo, D.A. Guo：Simultaneous determination of gallic acid, albiflorin, paeoniflorin, ferulic acid and benzoic acid in Si-Wu decoction by high-performance liquid chromatography DAD method，J Pharm Biomed Anal， 2005. 37(4): p. 805-10.
7. Zhang, H., P. Shen, Y. Cheng：Identification and determination of the major constituents in traditional Chinese medicine Si-Wu-Tang by HPLC coupled with DAD and ESI-MS，J Pharm Biomed Anal， 2004. 34(3): p. 705-13.
8. Tagami, K., K. Niwa, Z. Lian, J. Gao, H. Mori, T. Tamaya：Preventive effect of Juzen-taiho-to on endometrial carcinogenesis in mice is based on Shimotsu-To constituent，Biol Pharm Bull， 2004. 27(2): p. 156-61.
9. Sheng, Y., L. Li, J. Zhang, D. Guo：Simultaneous determination of albiflorin and paeoniflorin in rat urine by solid-phase extraction and high-performance liquid chromatography following oral administration of Si-Wu decoction，Biomed Chromatogr， 2004. 18(10): p. 785-90.
10. Sheng, Y., L. Li, C. Wang, Y. Li, D. Guo：Solid-phase extraction-liquid chromatographic method for the determination and pharmacokinetic studies of albiflorin and paeoniflorin in rat serum after oral administration of Si-Wu decoction，J Chromatogr B Analyt Technol Biomed Life Sci， 2004. 806(2): p.
127-32.
11. Liang, Q.D., X.Q. Lu, Z.C. Ma, H.L. Tan, B.P. Ma, Y. Gao, S.Q. Wang：
[Preliminary study on hematopoietic constituents of Si-Wu-Tang]，Zhongguo Zhong Yao Za Zhi， 2004. 29(6): p. 546-9.
12. Yasuda, T., A. Takasawa, T. Nakazawa, J. Ueda, K. Ohsawa：Inhibitory effects of urinary metabolites on platelet aggregation after orally administering Shimotsu-To, a traditional Chinese medicine, to rats，J Pharm Pharmacol， 2003.
55(2): p. 239-44.
13. Ma, Z.C., Y. Gao, H.L. Tang, S.Q. Wang：[The effects of Si-Wu-Tang on serum protein of blood deficient mice induced by radiation]，Zhongguo Zhong Yao Za Zhi， 2003. 28(11): p. 1050-3.
14. Liang, Q.D., W.H. Li, H.X. Wang, S.Q. Wang： [Saccharide analysis of Si-Wu-Tang by automated multiple development and off-line coupling thin
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layer chromatography electrospray ionization mass spectrometry techniques]， Zhongguo Zhong Yao Za Zhi， 2003. 28(7): p. 632-5.
15. Lian, Z., K. Niwa, J. Gao, K. Tagami, M. Hashimoto, Y. Yokoyama, H. Mori, T.
Tamaya： Shimotsu-To is the agent in Juzen-taiho-to responsible for the prevention of endometrial carcinogenesis in mice，Cancer Lett， 2002. 182(1): p.
19-26.
16. Dai, Y., P.P. But, Y.P. Chan, H. Matsuda, M. Kubo： Antipruritic and antiinflammatory effects of aqueous extract from Si-Wu-Tang，Biol Pharm Bull，
2002. 25(9): p. 1175-8.
17. Tahara, E., T. Satoh, K. Toriizuka, H. Nagai, S. Nunome, Y. Shimada, T. Itoh, K.
Terasawa, I. Saiki：Effect of Shimotsu-To (a Kampo medicine, Si-Wu-Tang) and its constituents on triphasic skin reaction in passively sensitized mice， J Ethnopharmacol， 1999. 68(1-3): p. 219-28.
18. Lee, S.E., H. Oh, J.A. Yang, S.K. Jo, M.W. Byun, S.T. Yee, S.H. Kim：
Radioprotective effects of two traditional Chinese medicine prescriptions:
Si-Wu-Tang and si-jun-zi-tang，Am J Chin Med， 1999. 27(3-4): p. 387-96.
19. Watanabe, H.：Protective effect of a traditional medicine, Shimotsu-To, on brain lesion in rats，J Toxicol Sci， 1998. 23 Suppl 2: p. 234-6.
20. Sakuma, K., M. Ogawa, M. Kimura, K. Yamamoto, M. Ogihara：[Inhibitory effects of Shimotsu-To, a traditional Chinese herbal prescription, on ultraviolet radiation-induced cell damage and prostaglandin E2 release in cultured Swiss 3T3 cells]，Yakugaku Zasshi， 1998. 118(6): p. 241-7.
21. Onishi, Y., T. Yamaura, K. Tauchi, T. Sakamoto, K. Tsukada, S. Nunome, Y.
Komatsu, I. Saiki ： Expression of the anti-metastatic effect induced by Juzen-taiho-to is based on the content of Shimotsu-To constituents，Biol Pharm Bull， 1998. 21(7): p. 761-5.
22. Kojima, S., K. Inaba, S. Kobayashi, M. Kimura：Inhibitory effects of traditional Chinese medicine Shimotsu-To and its included crude fractions on adjuvant-induced chronic inflammation of mice，Biol Pharm Bull， 1996. 19(1):
p. 47-52.
23. Hsu, H.Y., Y.H. Ho, C.C. Lin： Protection of mouse bone marrow by
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Si-Wu-Tang against whole body irradiation，J Ethnopharmacol， 1996. 52(2): p.
113-7.
24. Kobayashi, S., Y. Mimura, K. Notoya, I. Kimura, M. Kimura：Antiproliferative effects of the traditional Chinese medicine Shimotsu-To, its component cnidium rhizome and derived compounds on primary cultures of mouse aorta smooth muscle cells，Jpn J Pharmacol， 1992. 60(4): p. 397-401.
25. Watanabe, H., J.W. Ni, H. Ohta, X.H. Ni, K. Matsumoto：A kampo prescription, Shimotsu-To, improves scopolamine-induced spatial cognitive deficits in rats，
Yakubutsu Seishin Kodo， 1991. 11(3): p. 215-22.
25 篇文獻中，其中 18 篇文獻來自於 11 本國際 SCI 期刊（表 4-37），分別有 American Journal of Chinese Medicine, Biological & Pharmaceutical Bulletin, Biomedical Chromatography, Bioorganic & Medicinal Chemistry, Cancer Letters, Journal of Alternative and Complementary Medicine, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, Journal of Ethnopharmacology, Journal of Pharmaceutical and Biomedical Analysis, Journal of Pharmacy & Pharmacology and Menopause-The Journal of the north American Menopause Society。
表4- 37 發表到國外 SCI 期刊之四物湯文獻
題名 期刊名稱 期刊
來源
Impact factor 年份
1*
Anemia-related hemogram, uterine artery pulsatility index, and blood pressure for the effects of four-agents-decoction (si wu tang) in the treatment of primary dysmenorrhea.
J Altern
Complement Med. 美國 1.526 2009
2
Simultaneous quantification of active components in the herbs and products of Si-Wu-Tang by high performance liquid chromatography-mass spectrometry.
J Pharm Biomed
Anal. 美國 2.761 2009
96
3
Characterization of chemical components in extracts from
Si-wu decoction with proliferation-promoting effects on
rat mesenchymal stem cells.Bioorg Med Chem. 美國 2.662 2008
4 Effects of four Si-Wu-Tang's constituents and their
combination on irradiated mice. Biol Pharm Bull. 日本 1.614 2006 5*
Si-Wu-Tang and its constituents promote mammary duct
cell proliferation by up-regulation of HER-2 signaling. Menopause. 美國 3.672 2006
6
Simultaneous determination of gallic acid, albiflorin, paeoniflorin, ferulic acid and benzoic acid in Si-wu
decoction by high-performance liquid chromatography
DAD method.J Pharm Biomed
Anal. 美國 2.761 2005
7
Preventive effect of Juzen-taiho-to on endometrial carcinogenesis in mice is based on Shimotsu-to constituent.
Biol Pharm Bull. 日本 1.614 2004
8
Identification and determination of the major constituents in traditional Chinese medicine Si-Wu-Tang by HPLC coupled with DAD and ESI-MS.
J Pharm Biomed
Anal. 美國 2.761 2004
9
Simultaneous determination of albiflorin and paeoniflorin in rat urine by solid-phase extraction and high-performance liquid chromatography following oral administration of Si-Wu decoction.
Biomed
Chromatogr. 英國 1.661 2004
10
Solid-phase extraction-liquid chromatographic method for the determination and pharmacokinetic studies of albiflorin and paeoniflorin in rat serum after oral administration of Si-Wu decoction.
J Chromatogr B Analyt Technol Biomed Life Sci.
荷蘭 2.935 2004
11
Inhibitory effects of urinary metabolites on platelet aggregation after orally administering Shimotsu-to, a traditional Chinese medicine, to rats.
J Pharm
Pharmacol. 英國 1.718 2003
12 Antipruritic and antiinflammatory effects of aqueous
extract from Si-Wu-Tang. Biol Pharm Bull. 日本 1.614 2002
97
13
Shimotsu-to is the agent in Juzen-taiho-to responsible for
the prevention of endometrial carcinogenesis in mice. Cancer Lett. 荷蘭 3.398 2002 14 Radioprotective effects of two traditional Chinese
medicine prescriptions: Si-Wu-Tang and si-jun-zi-tang. Am J Chin Med. 美國 1.122 1999
15
Effect of Shimotsu-to (a Kampo medicine, Si-Wu-Tang) and its constituents on triphasic skin reaction in passively sensitized mice.
J Ethnopharmacol. 愛爾
蘭 2.049 1999
16
Expression of the anti-metastatic effect induced by Juzen-taiho-to is based on the content of Shimotsu-to constituents.
Biol Pharm Bull. 日本 1.614 1998
17
Inhibitory effects of traditional Chinese medicine
Shimotsu-to and its included crude fractions on
adjuvant-induced chronic inflammation of mice.Biol Pharm Bull. 日本 1.614 1996
18* Protection of mouse bone marrow by Si-Wu-Tang against
whole body irradiation. J Ethnopharmacol. 愛爾
蘭 2.049 1996
表4-37 之筆次後有標示*號者(1*、5*、18*)為台灣學者發表之文獻。
根據2007 年的 impact factor，發現有收載四物湯的 SCI 期刊之 impact factor 分佈自1.122~3.672，分別來自美國（7 篇）、日本（5 篇），剩下 6 篇分別來自於 英國、愛爾蘭及荷蘭（每個國家各佔兩篇）。其餘15 篇非 SCI 期刊有 11 篇來自 中國的Zhong Yao Cai（中藥材）, Zhong guo zhong yao za zhi（中國中藥雜誌），
另外4 篇則來自於日本的 Japanese Journal of Psychopharmacology, The Japanese Journal of Pharmacology and Journal of Toxicology Sciences。在 Pudmed 資料庫投 稿的學者們皆以英文發表，主要來自亞洲地區的中國（佔18 篇）與日本（佔 10 篇），其次是台灣（佔 3 篇）、香港與南韓（各佔 1 篇）。25 篇文獻中主要研 究領域以藥理與分子生物學研究（佔24 篇）為主，其次為成分分析（佔 8 篇），
只有一篇與臨床研究有關。臨床研究文獻主要探討原發性痛經之臨床療效評 估。目前還未發現與四物湯醫史與類似經驗性或社會調查型研究相關之文獻發 表在國外期刊。
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