明大學生物藥學研究所碩士論文

參考文獻

1. 陳拱北、吳新英、葉金川、鄭玉娟 1968-1976. 台灣地區及其他分類地區 別各種

癌症死亡率彩色圖 台北：行政院國家科學委員會。

2. 鄭雅文 87 學年度 中草藥對引發癌細胞細胞程式凋亡及抑制生長之研究 國立陽

明大學生物藥學研究所碩士論文

3. Folkman J. 1990. What is the evidence that tumers are angiogenesis dependent? J.

Natl Cancer Inst. 82,4~6

4. Gabriele B., Kashi J., Kin-Ming Lo, et al. 1999. Effect of angiogenesis inhibitors on multistage carcinogenesis in mice. Science 284,808~812

5. Hayes A.J., Li L.Y., Lippman M.E. 1999. science, mwdicine, and the future.

Antivascular therapy: a new approach to cancer treatment. BMJ 318,853~856

6. Vander, Sherman, Luciano 1994. human physioligy. international sixth edition 429~444

7. Roberto M., Jesus V.S., Katherine M.M., et al. 1998. Differential effects of hepatocyte growth factor isoforms on epithelial and endothelial tubulogenesis. Cell Grow.

Different. 9,355~365

8. Hua L., Mohanraj D., Ruediger V., et al. 1999. Kringle 5 causes cell cycle arrest and apoptosis of endothelial cells. Biochem. Biophys. Res. Communi. 258,668~673

9. Clement B., Musso O., Lietard J. et al. 1999. Homeostatic control of angiogenesis: A newly identified function of the liver. Hepatology 29,621~623

10. 謝文全重輯 1995. 神農本草經(古今功能輯注本) 中國藥學研究所 第 20 味藥 11. 馬繼興 1995.12 神農本草經輯注北京人民衛生出版社 215~216

12. 王筠默、王恒芬 1988. 神農本草經校証 吉林科學技術出版社 303~304 13. 尚志鈞輯校 1986.6 名醫別錄 115~116

14. 陶弘景校注 1987.2 本草經集注 南大阪印刷 59

15. 岡西為人 1964.4 重輯新修本草 國立中國醫藥研究所 197

16. 盧多遜、李昉 尚志鈞輯校 1998.5 開寶本草(輯複本) 安徽科學技術出版社 184 17. 謝文全、李一宏 1989. 重輯嘉祐補註神農本草 中國藥學研究所 86~87

18. 謝文全 1993.12 重輯圖經本草 中國藥學研究所 293~294

19. 唐慎微 重修政和經史證類備用本草 卷八 草部中品之上(古書)

20. 唐慎微 1993.5 重修政和經史證類備用本草 華夏出版社 230 21. 唐慎微 1986.6 經史證類大觀本草 中國藥學研究所 228~229 22. 李時珍 明 1994. 本草綱目 中醫古籍出版社 340~342

23. 李時珍 明 1995. 本草綱目 重慶大學出版社 67

24. 吳其濬 清 1974. 植物名實圖考長編 世界書局 348~349 25. 陳嘉謨 明 1988. 本草蒙筌 人民衛生出版社 80~81 26. 陳士鐸 清 1996.7 本草新編 中國中醫藥出版社 124~125 27. 嚴潔 清 1997.12 得配本草 中國中醫藥出版社 48~49 28. 張璐撰 清 1996.7 本經逢原 北京中國中醫藥出版社 45~46

29. 沙世炎、徐禮燊等編 1982.3 中草藥有效成分分析法人民衛生出版社 211~213 30. 國家中醫藥管理局 1998.1 中華本草(精選本) 上海科學技術出版社 1682~1694 31. Motoo Y. & Sawabu N. 1994. Antitumer effects of saikosaponins, baicalin and

baicalein on human hepatoma cell lines. Cancer Lett. 86,91~95 32. 盧宏民撰 本草藥性大辭典 73.3 五州出版社 409~413

33. Tang W., Eisenbrand G. 1992. Chinese drugs of plant origin. (chemistry, pharmacology, and use in traditional and modern medicine) 919~929

34. 賴妙英 1999. 黃芩煎劑中黃芩 在人體之口服吸收 中國醫藥學院中國藥學研究

所碩士論文

35. Muto R., Motozuka T., Nakano M., et al. 1998. The chemical structure of new substance as the metabolite of baicalin and time profiles for the plasma concentration after oral adiministration of Sho-Saiko-To in human. Yakugaku-Zasshi 118,79~87 36. 抗癌中草藥 1987.8 啟業書局 129~132

37. Ryu S.H., Ann B.Z., Pack M.Y. 1985. The cytotoxic principle of Scutellariae radix against L1210 cell. Planta Med. 5,462

38. Yuko M., Norie K., Shuji T. 1996. Cell death induced by baicalein in human hepatocellular carcinoma cell lines. Jpn. J. Cancer Res. 87,170~177

39. Huang H.C., Wang H.R., Hsieh L.M. 1994. Antiproliferative effect of baicalein, a flavonoid from a chinese herb, on vascular smooth muscle cell. Eur. J. Pharmacol.

251,91~93

40. Lodish H., Baltimore D., Berk A., et al. 1995. Molecular cell biology. Scientific american books third edition (Chapter 5 Cell division and the cell cycle) 177~185 41. Krtolica A., Krucher NA., Ludlow JW. 1999. Molecular analysis of selected cell cycle

regulatory proteins during aerobic and hypoxic maintenance of human ovarian carcinoma cells. Br-J-Cancer ang 80,1875~83

42. Polyak K., Lee M.H., Koff A. et al. 1994. Cloning p27

, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78,59~66 43. 行政院衛生署中醫藥委員會 1999. 中醫藥年報 第十七期第三冊 555~598 44. 楊家駱 1974.4 植物名實圖考 世界書局 卷七 山草類 165~166

45. 韓維恒主編 1993.12 中藥正別名集 湖南科學技術出版社 171~173

46. 重修政和經史證類備用本草 卷八 草部中品之上(古書)

47. 劉嘉朝主編 1993.12 中藥研究文獻摘要第五卷 中國醫藥科學技術出版社

1020~1027

48. 楊繼祥主編 1993.5 藥用植物栽培學 農業出版社 40

49. 中國醫藥科學院藥物研究所 1993.1 中藥志(Ⅰ) 人民衛生出版社 546~555

50. 周榮漢主編 1993. 中藥資源學 中國醫藥科學技術出版社 453~457

51. 海峽兩岸植物多樣性與保育學術研討會 議程論文摘要 1997.11.12 國立自然科 學博物館 13,22~23

52. 謝文全 1995.7 神農本草經之考察與重輯 中國醫藥學院中國藥學研究所博士論

文

53. 行政院衛生署中醫藥委員會 1985.10.10 中華民國中藥典範第一輯附錄 中藥典

編輯委員會 91~94

54. 崔毅民 1978.6 本草集成 建豐彩色印刷公司 200~201 55. 裴鑒 1973.10 中國藥用植物誌 宏業書局 902~904

56. 楊見瑞等 1987.3 祁州中藥志 河北科學技術出版社 100~101

57. 謝宗萬編著 1994.11 中藥材品種論述(中冊) 上海科學技術出版社 550~556 58. 現代本草中國藥材學(上冊) 1974. 啟業書局印行 637~640

59. 中醫藥學 1985.12 南京藥學院 江蘇科學技術出版社 143~145

60. 徐國鈞等編 1996.10 中國藥材學(上) 中國醫藥科技出版社 398~402

61. 陳德華、王君根主編 1994.3 中藥的質量及其合理應用江蘇科學技術出版社

268~270

62. 謝文全、甘偉松 1997.9 藥用植物學 國立中國醫藥學研究所 487

63. 行政院衛生署中醫藥委員會 1985.10.10 中華民國中藥典範第一輯第一冊 中藥

典編輯委員會 77~80

64. 郭南、張筑君 1993.12 常用中藥鑒定大全 黑龍江科學技術出版社 728~731

65. 楊曉穗 編著 1994.5 常用中藥材真偽理化鑒別 中國醫藥科學技術出版社

138~143

66. 陳忠川 1999.6 中藥材品質管制-組織型態鑑定 行政院衛生署中醫藥委員會

356~357

67. 那琦 1982. 黃芩之剖見 台灣藥學雜誌第十一卷第一期 43~45 68. 中醫藥學年報 1998.5 行政院衛生署中醫藥委員會編印 台北 12~15

69. 宋萬志等編 1995.5 常用中藥材品種整理和質量研究(北方編)第二冊 中國醫藥

科學院藥物研究所 795~838

70. 陰健、郭力弓主編 1995.6 中藥現代研究與臨床應用 學苑出版社 559~569 71. 中藥藥學 1985.12 南京藥學院 江蘇科技出版社 143~145

72. 肖崇原主編 1987.11 中藥化學 上海科學技術出版社 245~247

73. 楊云、馮衛生 1998.8 中藥化學成分提取分離手冊 中國醫藥科技出版社 北京

295~297

74. 許鴻源 1980.5 中藥材之研究 新醫藥出版社 22~24,568,566~567,725~726

75. 臺 灣 藥 學 雜 誌 1982. 第 三 十 四 卷 第 二 期 國 立 台 灣 師 範 大 學 化 學 研 究 所 179~185,276~282(Journal of the Taiwan Pharmaceutical Association Vol. 34 No. 2 1982)

76. 駱和生 1987.7 中藥與免疫(清熱類藥) 廣東科學技術出版社 1~3,5~13 77. 高木敬次郎著 1982.4 和漢藥物學 國立中國醫藥研究所 87~90

78. 謝明村等編 1988. 中國藥材學 中國醫藥學院協編 正中書局印行 171~174 79. 顏正華 1994.2 中藥學 知音出版社 137~140

80. 周煌、王筠默 1986. 中藥藥理 上海科學技術出版社 55~58,97~99

81. 趙亦成、蔣紀洋 1995. 淄博本草 中國中醫藥出版社 394~620

82. 新編中藥大辭典(下) 1978.9 新文豐出版公司 133~137

83. 全國中草藥匯編 1975.9 全國中草藥匯編編寫組編 北京 759~761 84. 許鴻源等 1985.1 簡明藥材學 新醫藥出版社 120~121

85. 黃泰康主編 1994.4 常用中藥成分與藥理手冊 中國醫藥科技出版社 1569~1574 86. 中藥藥理(下篇) 1988.10 彥欣中西醫藥學術研習中心 弘祥出版社 130~133 87. Kubo m., Matsuda H., Tanaka M., et al. 1984. Studies on scutellariae radix Ⅶ.

Anti-arthritic and anti-inflammatory actions of methanolic extract and flavonoid components from Scutellariae radix. Chem. Pharm. Bull. 32,2724~2729

88. Yoshiyuki K., Michnori K., Kimiyo K. et al. 1982. Studies on scutellariae radix Ⅴ.

Effects on ethanol induced hyperlipemia and lipolysis in isolated fat cells. Chem.

Pharm. Bull. 30,219~222

89. Yoshiyuki K., Michnori K., Tadato T. et al. 1981. Studies on scutellariae radix Ⅲ.

Effects on metabolism in serum, liver and fat cell of rats. Chem. Pharm. Bull.

19,2308~2312

90. Yoshiyuki K., Michnori K., Tadato T. et al. 1981. Studies on scutellariae radix Ⅳ.

Effects on lipid peroxidation in rat liver. Chem. Pharm. Bull. 19,2610~2617

91. Kubo M., Matsuda H., Tani T. et al. 1985. Studies on scutellariae radix ⅩⅡ.

Anti-thrombic actions of various flavonoids from Scutellariae radix. Chem. Pharm.

Bull. 33,2411~2415

92. Butenko I.G., Gladtchenko S.V., Galushko S.V. 1993. Anti-inflammatring properties and inhibition of leukotriene C4 biosynthesisin vitro by flavonoid baicalein from scutellariae baicaleinsis G

roots. Agents & actions 39,c49~51

93. Nyby M.D., Sasaki M., Ideguchi Y. et al. 1996. Platelet lipoxygenase inhibitors attenuate thrombin and thromboxane minetic induces intracellular calcium mobilization and platelet aggregation. J. Pharmacol. Experim. Therap. 278,503~509 94. Miyahara M., Ohtaka H., Katayama H. et al. 1993. Structure-activity relationship of

flavonoids in suppressing rat liver lipid peroxidation. Yakugaku-Zasshi. 113,133~154 95. Gao D., Sakurai K., Chen J. et al. 1995. Inhibition of microsomal lipid peroxidation by

baicalein: a possible formation of iron-baicalein complex. Biochem. Mol. Biol.

Internat. 39,215~225

96. Gao D., Sakurai K., Chen J. et al. 1995. Protection by baicalein against ascorbic acid-induced lipid peroxidation of rat liver microsomes. Rear. Communi. Mol. Pathol.

Pharmac. 90,130~114

97. Yano H., Mizoguchi A., Fukuda K. et al. 1994. The herbal medicine Sho-saiko-to inhibits proliferation of cancer cell line by inducing apoptosis and arrest at the G0/G1 phase. Cancer Reasearch 54(2),448~454

98. 中藥毒理學 1989.9 啟業書局 23~24

99. 胡 敏 秀 1997.6 黃 芩 有 效 成 分 黃 芩 元 在 家 兔 之 生 物 藥 劑 學 研 究

(Biopharmaceutical studies of baicalein in rabbits) 中國醫藥學院中國藥學研究所藥 學碩士論文

100. 王浴生主編 1983.8 中藥藥理與應用 北京科學技術出版社 956~965

101.Dasso M. & Newport J.W. 1990. Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro:Stuides in Xenopus. cell 61,811~823

102.Norbury C. & Nurse D. 1993. Animal cell cycles and their control. Ann. Rev. Biochem.

61,441~470

103.Murray A.W., Solomon M.J., Kirschner M.W. 1989. The role of synthesis and degradation in the control of maturation promoting factor activity. Nature 339,280~286

104.Nurse P. 1990. Universal control mechanism regulating cell cycle timing of M-phase.

Nature 344,503~508

105.Gerring S.L., Spencer F., Hieter P. 1990. The CHL1(CTF1) gene product of S.

cerevisiae is improtant for chromosome transmission and normal cell cycle progression in G2/M. EMBO J. 9,4347~4358

106.Poo Y.C., Yamashita K., Adaczewski J. et al. 1993. The cdc2-related protein p40

is the catalytic subunit of a protein kinase that can activate p33

and p34

. EMBD J.

12,3123~3132

107.Krek W. & Niggea E.A. 1991. Differential phosphorylation of vertebrate p34

kinase at the G1/S and G2/M transitions of the cell cycle: Identification of major phosphorylation site. EMBO J. 10,305~316

108.Baldin V., Lukkas J., Marcote M.J. et al. 1993. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev. 7,812~821

109.Harper J.W., Adami G.R., Wei N. et al. 1993. The p21 Cdk-interacting protein CIP1 is

a potent inhibitor of G1 cyclin-dependent kinases. Cell 75,805~816

110.Koff A., Ohtsuki M., Polyas K. 1993. Negative regulation of G1 in mammalian cells:

inhibition of cyclin E-dependent kinase by TGF- β. Science 260,536~539

111.Paagano M. & Draetta G 1991. Cyclin A, cell cycle control and oncogenesis. Prog.

Growth Factor Res. 3,267~277

112.Featherstone C. & Russell P. 1991. Fission yeast p107

mitotic inhibitor is a tyrosine/serine kinase. Nature 349,808~811

113.Glotzer M., Murray A.W. , Kirschner M.W. 1991. Cyclin is degraded by the ubiquitin pathway. Nature 349,132~138

114.Serrano M., Gomez-Lahoz E., Depinho R.A. et al. 1995. Inhibition of Ras-induced proliferation and cellular transformation by p16

. Science 207,249~252

115.Richards P.S., Saba T.M., Del Vecchio P.J. et al. 1986. Matrix fibronectin disruption in association with altered endothelial cell adhesion induced by activated polymorphonuclear leukocytes. Exp. Mol. Pathol. 45,1~21

116. 李 宥 萱 1998. Inhibitory mechanisms of 2-phenyl-4-quinolone and 1,3,6,7-tetrahydroxyxanthone on serotonin-induced rat heart endothelial cells permeability 中國醫藥學院藥物化學研究所博士論文

117.Hämmerle H., Betz E., Herr D. 1991. Human endothelial cells are stimulated and vascular smooth muscle cells are inhibited in their proliferation and migration by heparins. Vaso. 20,207~214

118.Kyo R., Nakahata N., Sakakibara I., et al. 1998. Baicalin and baicalein, constituents of an important medicinal plant, inhibit intracellular Ca

elevation by reducing phospholipase C activity in C6 rat glioma cells. J. Pharm. Pharmacol. 50,1179~1182 119.Tricoli J.V., Sahai B.M., Mc Lormick P.J. et al. 1985. DNA topoisomerase ⅠandⅡ

activities during cell proliferation and the cell cycle in cultured mouse embryo fibroblast (C

H

T1/2) cells. Exp. Cell Res. 158,1~14

120.Austin C.A., Plael S., Ono K. et al. 1992. Site-specific DNA cleavage by mammalian DNA topoisomerase Ⅱ induced by novel flavone and catechin derivatives. Biochem.

J. 282,883~889

121.Matsuzaki Y., Kurokawa N., Terai S., et al. 1996. Cell death induced by baicalein in human hepatocellular carcinoma cell lines. Jpn. J. Cancer Res. 87,170~177

122.Tomoo I. & Edwin K.J. 1999. Strong antiproliferative effects of baicalein in cultured rat hepatic stellate cells. Eur. J. Pharmacol. 378,129~135

123.Majno G. & Jois I. 1995. Apoptosis, oncosis, and necrosis. An overview of cell death.

Am. J. Pathol. 146,3~15

124.Kerr J.F., Winterford C.M., Harmon B.V. 1994. Apoptosis, It’s signifivance in cancer and cancer therapy. Cancer 73,2013~2026

125.Yoshino M. & Murakami K 1998. Interaction of iron with polyphenolic compounds:

Application to antioxidant characterization. Analytical Biochemistry 257,40~44

126.Shaw S., Naegeli P., Etter JD., et al. 1995. Role of intracellular signalling pathways in hydrogen peroxide-induced injury to rat glomerular mesangial cells. Clin. Exper.

Pharm. Physiol. 22,924~933

127.Dayuan G., Riichi T., Hitoshi M., et al. 1998. Protective effects of baicalein against cell damage by reactive oxygen species. Chem. Pharm. Bull. 46,1383~1387

128.Ewen M.E., Sluss H.K., Whitehouse L.L., et al. 1993. TGF β effects on expression of G1 cyclins and cyclin-dependent protein kinase. Proc. Natl. Acad. Sci. USA 90,10315~10319

129.Geng Y. & Weinberg R.A. 1993. Transforming growth factor β effects on expression of G1 cyclins and cyclin-dependent protein kinase. Proc. Natl. Acad. Sci. USA 90,10315~10319

130.Dulic V., Kufmann W.K., Wilson S.J., et al. 1994. p53-dependent inhibition of cyclin-dependent kinase activity in human fibroblasts during-raduced G1 arrest. Cell 76,1013~1023

131.Nasmyth K. 1996. Viewpoint: putting the cell cycle in order. Science 274,1643~1645 132.Matsushime H., Ewen M.E., Strom D.K., et al. 1992. Identification and properties of

an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins.

Cell 71,323~334

133.Nigg E.A. 1995. Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. BioEssays 17,471~480

134.Sherr C.J. 1993. Mammalian G1 cyclins. Cell 73,1059~1065

135.Pines J. 1992. Cell proliferation and control. Curr. Opin. Cell Biol. 4,144~148

136.Matsushime H., Roussel M.F., Ashmun R.A., et al. 1991. Colony-stimulating factor 1 regulates novel cyclins during the G1 ohase of the cell cycle. Cell 65,701~713

137.Draetta G. & Beach D. 1988. Activation of cdc2 protein ki nase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell 54,17~26

138.Pines J. 1993. Cyclins and cyclin-dependent kinases: take your partners. Trend.

Biochem. Scien. 18,195~197

139.Quelle D.E., Ashmun R.A., Shurtleff S.A. et al. 1993. Overexpression of mouse

D-type cyclins accelerates G1 phase in rodent fibroblasts. Gene Dev. 7,1559~1571

140.Jiang W., Kahn S.M., Zhou P., et al. 1993. Overexpression of cyclin D1 in rat

fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression. Oncogene 8,3447~3457

141.Resnitzky D., Gossen M., Bujard H., et al. 1994. Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol. Cell. Biol.

14,1669~1679

142.Ohtani K., DeGregori J., Nevins J.R. 1995. Regulation of the cyclin E gene by transcription factor E2F1. Proc. Natl. Acad. Sci. USA 92,12146~12150

143.Weinberg R.A. 1995. The retinoblastoma protein and cell cycle control. Cell 81,323~330

144.Murray A.W. & Kirschner M.W. 1989. Cyclin synthesis drives the early embryonic cell cycle. Nature 339,275~280

145.Sherr C.J. & Roberts J.M. 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9,1149~1163

146.Zhang H., Hannon G.J., Beach D. 1994. p21-containing cyclin kinases exist in both active and inactive states. Genes Dev. 8,1750~1758

147.Waga S., Hannon G.J., Beach D., et al. 1994. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369,574~578 148.Flores-Rozas H., Kelman Z., Dean F.B., et al. 1994. Cdk-interacting protein 1 directly

binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme. Proc. Natl. Acad. Sci. USA 91,8655~8659 149.El-Deiry W.S., Tokino T., Velculescu V.E., et al. 1993. WAF1, a potential mediator of

p53 tumor suppression. Cell 75,817~825

150.Bargonetti J., Reynisdottir I., Friedman P.N. 1992. Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53. Genes Dev.

6,1886~1898

151.Zambetti G.P., Bargonetti J., Walker K., et al. 1992. Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element. Genes Dev.

6,1143~1152

152.Prives C. 1993. Doing the right thing: feedback control and p53. Curr. Opin. Cell Biol.

5,214~218

153.Stromblad S., Becker J.C., Yebra M., et al. 1996. Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis.

J. Clin. Inves. 98,426~433

154.Halevy O., Novitch B.G., Spicer D.B., et al. 1995. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science 267,1018~1021 155.Skapek S.X., Rhee J., Spicer D.B., et al. 1995. Inhibition of myogenic differentiation

in proliferating myoblasts by cyclin D1-dependent kinase. Science 267,1022~1024 156.Liu M., Lee M.H., Cohen M., et al. 1996. Transcription activation of the Cdk inhibitor

p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line

U937. Gene Dev. 10,142~153

157.Hannon G.J. & Beach D. 1994. p15

is a potential effector of TGF- β-induced cell cycle arrest. Nature 371,257~259

158.Peter M. & Herskowitz I. 1994. Joining the complex: cyclin-dependent kinase inhibitory proteins and the cell cycle. Cell 79,181~184

159.Cobrinik D., Dowdy S.F., Hinds P.W., et al. 1992. The retinoblastoma protein and the regulation of cell cycling. Trend in Biochem. Scien. 17,312~315

160.Hurford R.K., Cobrinik D., Lee M.H., et al. 1997. pRb and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Gene Dev.

11,1447~1463

161.Ruoslahti E. & Giancotti F.G. 1989. Integrins and tumer cell dissemination. Cancer Cell 1,119~126

162.Ingber D.E. & Folkman J. 1989. How does extracellular matrix control capillary morphogenesis? Cell 59,803~805

163.Edelman G.M. & Crossin K.L. 1991. Cell adhesion molecules: Implications for a molecular histology. Annu. Rev. Biochem. 60,155~190

164.Boucant J.C., Darribere T., Poole T.J., et al. 1984. Biologically active synthetic peptides as probes of embryonic development: A competitive peptide inhibitor of fibronectin function inhibitors gastrulation in amphibian embryos and neural crest cell migration. J. Cell Biol. 99,1822~1830

165.Peng W., James B.H., Stuart K.W., et al. 1994. Integrin-binding peptide in solution inhibits or enhance endothelial cell migration, predictably from cell adhesion. Ann.

Biomed. Engin. 22,144~152

166.Giraux J.L., Matou S., Bros A., et al. 1998. Modulation of human endothelial cell proliferation and migration by fucoidan and heparin. Eurp. J. Cell Biol. 77,352~359 167.Humphries M.J., Olden K., Yamad K.M. 1986. A synthetic peptide from fibronectin

inhibits experimental metastasis of murine melanoma cells. Science 233,467~470 168.Nicosia R.F. & Bonanno E. 1991. Inhibition of angiogenesis in vitro by arg-gly-asp

containing synthetic peptide. Am. J. Pathol. 138,829~833

169.Ausprunk D.H.& Fokman J. 1977. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during angiogenesis. Microva. Res.

14,53~65

170.Montesano R., Vassalli J.D., Baird A., et al. 1986. Basic fibroblast growth factor induces angiogenesis in vitro. Proc. Natl. Acad. Sci. USA. 83,7297~7301

171.Moscatelli D. & Rifkin D.B. 1988. Menbrane matrix localization of proteases: a common theme in tumer invasion and angiogenesis. Biochem. Biophys. Acta.

948,67~85

172.Weidner N. 1991. Tumer angiogenesis and metastasis: correlation in invasive breast

carcinoma. N. Engl. J. Med. 324,1~8

173.Deepa T., Anoop K.S., Gurmel S.S., et al. 1998. Inhibition of Angiogenic differentiation of human umbilical vein endothelial cells by curcumin. Cell grow.

Different. 9,305~312

174.Kleinman H.K., McGarrey M.L., Liotta A., et al. 1982. Isolation and characterization of type Ⅳ procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma. Biochem. 21,6188~6193

175.Mukherjee G., Rasmusson B., Linner J.G., et al. 1998. Organization and mobility of CD11b/CD18 and targeting of superoxide on the surface of degranulated human neutrophils. Arch. Biochem. Biophys. 357,164~172

176.Sampath R., Gallagher P.J., Pavalko F.M. 1998. Cytoskeletal interactions with the leukocyte integrin beta2 cytoplasmic tail. Activation-dependent regulation of associations with talin and alpha-actinin. J. Biol. Chem. 273,33588~33594

177.Kucik D.F., Dustin M.L., Miller J.M., et al. 1996. Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes. J. Clin.

Invest. 97,2139~2144

178.Luna E.J. & Hitt A.L. 1992. Cytoskeleton-plasma membrance interactions. Science 258,955~964

179.Clark E.A. & Brugge J.S. 1995. Integrins and signal transduction pathways: The road taken. Science 268,233~239

180.Kiyoko U. & Masayuki M. 1999. Stress fiber networks in sinus endothelial cells in the rat spleen. Anat. Rec. 254,22~27

181.Hynes R.O. 1992. Integrins: Versatility, modulation, and signaling in cell adhesion.

Cell 69,11~25

182.Arroyo A.G., Campanero M.R., Sanchez M.P., et al. 1994. Induction of tyrosine phosphorylation during ICAM-3 and LFA-1 mediated intercellular adhesion, and it’s regulation by the CD45 tyrosine phosphatase. J. Cell Biol. 126,1277~1286

183.Takahashi M.O., Takahashi Y., Iida K.,et al. 1999. Growth hormone stimulates tyrosine phosphorylation of focal adhesion kinase and actin stress fiber formation in human osteoblast-like cells,Saos2. Biochem. Biophys. Res. Communi. 263,100~106 184.Staffan S.& David A.C. 1996. Cell adhesion and angiogenesis. Cell Biology

6,462~468

185.Jocksch B., Bubeck P., Giehl K., et al. 1995. The molecular architecture of focal adhesions. Annu. Rev. Biol. 11,379~416

186.Jones S. & Thornton J.M. 1996. Principles of protein-protein interactions. Proc. Natl.

Acad. Sci. USA 93,13~20

187.Buckley C.D., Rainger G.E., Bradfield P.F., et al. 1998. Cell adhesion: more than just glue. Mol. Membr. Biol. 15,167~176

188.Dedhar S. 1999. Integrins and signal transduction. Curr. Opin. Hematol. 6,37~43

189.Meredith J.E., Fazeli B., Schwartz M.A. 1993. Mol. Biol. Cell 4,953~961

190.Re F., Zanetti A., Sironi M., et al. 1994. Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells. J. Cell Biol.

127,537~546

191.Hynes R.O. 1987. Integrins: a family of cell surface receptors. Cell 48,549~554

192.Albelda S.M. & Buck C.A. 1990. Integrins and other cell adhesion molecules. FASEB J. 4,2868~2880

193.Lasky L.A. 1992. Selectins: interpreters of cell-specific carbohydrate information during inflammation. Science 258,964~969

194.Takeichi M. 1987. Cadherins: a molecular family essential for selective cell-cell adhesion and animal morphogenesis. Trends Genet. 3,213~217

195.Brummendorf T.& Rathjen F.G. 1995. Cell adhesion molecules:immunoglobulin superfamily protein. Prof. 2,293~1108

196.Löster K. & Horstkorte R. 2000. Enzymatic quantification of cell-matrix and cell-cell adhesion. Micron 31,41~53

197.Yoshiyuki K., Nobutoshi M., Hiromichi O. 1997. Effect of baicalein isolated from Scutelaria baicalensis on interleukin 1 β - and tumer necrosis factor α-induced adhesion molecule expression in cultured human umbilical vein endothelial cells. J.

Ethnopharmacol. 57,63~67

198.Yoshiyuki K., Kumi Y., Nobutoshi M. et al. 1997. Effects of flavonoids isolated from Scutellariae Radix on the production of tissue-type plasminogen activator and plasminogen activator inhibitor-1 induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. J. pharm. Pharmacol.

49,816~822

199.Cheng Y.F. & Kramer R.H. 1989. Human microvascular endothelial cells express integrin-related complexes that mediate adhesion to the extracellular matrix. J. Cellu.

Physiol. 139,275~286

200.Ruoslahti E. & Piersbacher M.D. 1987. New perspectives in cell adhesion, RGD and integrins. Science 238,491~497

201.Ruoslahti E. 1996. RGD and other recognition sequences for integrins. Annu. Rev. Cell

Dev. Biol. 12,697~715